Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion

Efficacy of photodynamic therapy in the management of oral premalignant lesions. A systematic review

“…Similar results were reported by Chen et al [15]. Results from these studies [15,16] suggest that PDT is a potential therapeutic strategy for the management of oral premalignant lesions. However, studies [17,18] have also reported recurrence rates of up to 36% following treatment of oral premalignant lesions using PDT.…”

“…Twenty-three studies, which did not fulfill the eligibility criteria, were excluded (Appendix A). In total, 13 studies [9,[15][16][17][18][19][20][21][22][23][24][25][26] were included and processed for data extraction. The pattern of the present study was customized to mainly summarize the relevant information.…”

“…The total number of subjects ranged between 5 patients and 147 individuals. Seven studies [9,15,16,[20][21][22][23] reported the mean age of study participants, which was between 51 years and 62.2 years (age range 30-98 years). Nine studies [9,15,16,[18][19][20][21][22][23] reported the gender of subjects, in which the number of female participants ranged between 0 and 65 individuals.…”

“…This interaction produces reactive oxygen species [11,12] that cause oxidative damage to microbial cell walls and pre-malignant and malignant cells [13][14][15]. In the study by Yu et al [16], 35 patients with oral verrucous hyperplasia (OVH) were treated using PDT. The results showed complete elimination of OVH with no recurrence up to 35 months of follow up.…”

Photodynamic Therapy to Eradicate Tumor Cells

“…PDT is a relative recent therapy, and excellent results have been reported after its application for the treatment of oral cancer and premalignant lesions (Allison et al, 2005;Yu et al, 2008), as well as bacterial and fungal infections (Teichert et al, 2002;Williams et al, 2006;Donnelly et al, 2008). The simplicity of PDT mechanism stimulated the interest for this therapy, which is characterized by the association of a photosensitizing agent (PS) and visible light with a wavelength compatible with the photosensitizer's absorption spectrum (Konopka & Goslinski, 2007;Buytaert et al, 2007).…”