Photodynamic therapy of melanoma skin cancer using carbon dot – chlorin e6 – hyaluronate conjugate

Beack, Songeun; Kong, Won Ho; Jung, Ho Sang; Hwan, In; Han, Seulgi; Kim, Hye Min; Kim, Ki Su; Yun, Seok Hyun; Hahn, Sei Kwang

doi:10.1016/j.actbio.2015.08.027

Cited by 118 publications

(55 citation statements)

References 34 publications

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“…They are mainly used for fluorescence imaging and drug delivery 25 in the medical field. Many CDs manufacturing methods have been developed, including pyrolysis 26 , hydrothermal 27 , calcination 28 , microwave assisted 29 , and laser-assisted 30 .…”

Section: Discussionmentioning

confidence: 99%

Novel carbon quantum dots from egg yolk oil and their haemostatic effects

Zhao

Zhang

Liu

et al. 2017

Sci Rep

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In this study, the properties of egg yolk oil (EYO) were investigated. Water extraction, dialysis, and ultrafiltration were used to extract and purify EYO, and microscopy, spectrophotometry, and chromatography were used to identify carbon dots (CDs) present in EYO (EYO CDs). Morphology analyses demonstrated that CDs were almost spherical, with an average size of <10 nm, a lattice spacing of 0.267 nm, and a composition of mainly C, O, and Fe. The solution showed bright blue fluorescence at 365 nm. Tail haemorrhaging and liver haemorrhaging experiments showed that CD-treated mice had significantly shorter bleeding times than did control mice. Coagulation assays suggested that EYO CDs stimulate the intrinsic blood coagulation system and activate the fibrinogen system. Thus, EYO CDs possess the ability to activate haemostasis, which may lead to further investigations of this ingredient of traditional Chinese medicine.

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Section: Discussionmentioning

confidence: 99%

Novel carbon quantum dots from egg yolk oil and their haemostatic effects

Zhao

Zhang

Liu

et al. 2017

Sci Rep

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“…[69] Conjugating HA to nanographene oxide or carbon dot-chlorin e6 particles enhanced their permeation and/or retention in skin. [70–71] Transdermal immunotherapy has been enabled by conjugating HA with antigenic peptides such as myostatin fragment [72] or ovalbumin. [73] HA can enhance the permeation of macromolecules to a greater degree than some small-molecule CPEs, [74] but not as much as some combinations of small-molecule CPEs.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Getting Drugs Across Biological Barriers

et al. 2017

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The delivery of drugs to a target site frequently involves crossing biological barriers. The degree and nature of the impediment to flux, as well as the potential approaches to overcoming it, depend on the tissue, the drug, and numerous other factors. Here we present an overview of approaches that have been taken to crossing biological barriers, with special attention to transdermal drug delivery. Technology and knowledge pertaining to addressing these issues in a variety of organs could have a significant clinical impact.

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“…In the same year, Wang et al developed conjugates by electrostatically connecting TMPyP with non-toxic CQDs [ 35 ]. In 2015, Beack et al synthesized a CQDs-Ce6-HA conjugate, which showed much higher photodynamic effect than that of free Ce6 and CQDs-Ce6 [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Carbon Dots @ Platinum Porphyrin Composite as Theranostic Nanoagent for Efficient Photodynamic Cancer Therapy

Yue

et al. 2018

Nanoscale Res Lett

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Photosensitizers are light-sensitive molecules that are highly hydrophobic, which poses a challenge to their use for photodynamic therapy. Hence, considerable efforts have been made to develop carriers for the delivery of PSs. Herein, we synthesized a new theranostic nanoagent (CQDs@PtPor) through the electrostatic interaction between the tetraplatinated porphyrin complex (PtPor) and the negatively charged CQDs. The size and morphology of as-prepared CQDs and CQDs@PtPor were characterized by a series of methods, such as XRD, TEM, XPS, and FTIR spectroscopy. The CQDs@PtPor composite integrates the optical properties of CQDs and the anticancer function of porphyrin into a single unit. The spectral results suggested the effective resonance energy transfer from CQDs to PtPor in the CQDs@PtPor composite. Impressively, the CQDs@PtPor composite showed the stronger PDT effect than that of organic molecular PtPor, suggesting that CQDs@PtPor is advantageous over the conventional formulation, attributable to the enhanced efficiency of 1O2 production of PtPor by CQDs. Thus, this CQDs-based drug nanocarrier exhibited enhanced tumor-inhibition efficacy as well as low side effects in vitro, showing significant application potential in the cancer therapy.Electronic supplementary materialThe online version of this article (10.1186/s11671-018-2761-5) contains supplementary material, which is available to authorized users.

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Photodynamic therapy of melanoma skin cancer using carbon dot – chlorin e6 – hyaluronate conjugate

Cited by 118 publications

References 34 publications

Novel carbon quantum dots from egg yolk oil and their haemostatic effects

Novel carbon quantum dots from egg yolk oil and their haemostatic effects

Getting Drugs Across Biological Barriers

Carbon Dots @ Platinum Porphyrin Composite as Theranostic Nanoagent for Efficient Photodynamic Cancer Therapy

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