Photodynamic therapy inhibits the formation of hypertrophic scars in rabbit ears by regulating metalloproteinases and tissue inhibitor of metalloproteinase-1

Wang, Q.; Dong, Yingying; Geng, Shuang; Su, Hui; Ge, Weifeng; Zhen, Changqing

doi:10.1111/ced.12265

Cited by 17 publications

(9 citation statements)

References 19 publications

(19 reference statements)

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“…Research efforts demonstrate that MMP regulation can improve hypertrophic scarring models in rabbits (Li, Kilani, Rahmani-Neishaboor, Jalili, & Ghahary, 2014; Wang et al, 2014). Though there are many studies that characterize differences in MMP composition in both animals and humans (Gawronska-Kozak, 2011; Manuel & Gawronska-Kozak, 2006; Tanriverdi-Akhisaroglu, Menderes, & Oktay, 2009; Witte et al, 1998), clinical trials in humans have yet to be performed.…”

Section: Targets Of Scarless Skin Regenerationmentioning

confidence: 99%

Scarless wound healing: Transitioning from fetal research to regenerative healing

Moore

Marshall

Barnes

et al. 2018

WIREs Developmental Biology

105

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Since the discovery of scarless fetal skin wound healing, research in the field has expanded significantly with the hopes of advancing the finding to adult human patients. There are several differences between fetal and adult skin that have been exploited to facilitate scarless healing in adults including growth factors, cytokines, and extracellular matrix substitutes. However, no one therapy, pathway, or cell subtype is sufficient to support scarless wound healing in adult skin. More recently, products that contain or mimic fetal and adult uninjured dermis were introduced to the wound healing market with promising clinical outcomes. Through our review of the major experimental targets of fetal wound healing, we hope to encourage research in areas that may have a significant clinical impact. Additionally, we will investigate therapies currently in clinical use and evaluate whether they represent a legitimate advance in regenerative medicine or a vulnerary agent. WIREs Dev Biol 2018, 7:e309. doi: 10.1002/wdev.309 This article is categorized under: Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration Plant Development > Cell Growth and Differentiation Adult Stem Cells, Tissue Renewal, and Regeneration > Environmental Control of Stem Cells.

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Section: Targets Of Scarless Skin Regenerationmentioning

confidence: 99%

Scarless wound healing: Transitioning from fetal research to regenerative healing

Moore

Marshall

Barnes

et al. 2018

WIREs Developmental Biology

105

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“…Furthermore, increased expression of MMP-1 was demonstrated to be responsible for kynurenine reduction of scarring in rabbit ear wounds [20] and for fibroblast growth factor-2-induced collagen degradation in mice subcutaneously transplanted with human hypertrophic scar tissue [21]. Additionally, the MMPs/TIMPs ratio was considerably increased leading to ECM degradation by photodynamic treatment of hypertrophic scars [22]. Collectively, these discoveries support the concept that correction of matrix remodeling could be a therapeutic option for hypertrophic scars.…”

Section: Cellular Basis Of Hypertrophic Scarsmentioning

confidence: 73%

Growth factor pathways in hypertrophic scars: Molecular pathogenesis and therapeutic implications

Lian

2016

Biomedicine & Pharmacotherapy

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“…The HS rabbit ear model was established based on Morris' method. [25][26][27] The rabbits were anesthetized with 20% urethane 1 g/kg ear vein. Via aseptic operation, a round wound of a diameter of 1 cm was made on the ventral side of the rabbit ear.…”

Section: In Vitro Evaluation Of Transdermal Permeationmentioning

confidence: 99%

<p>Transdermal permeability of triamcinolone acetonide lipid nanoparticles</p>

Qin¹,

Chen²,

Chen³

et al. 2019

IJN

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Background: Triamcinolone acetonide (TAA) is an effective and the most commonly used corticosteroid hormone for the treatment of hypertrophic scars (HSs). However, the clinically used dosage has poor tissue permeability and injection safety. By contrast, lipid nanoparticles (LNPs) have the advantage of high affinity for the skin. Materials and methods: This article describes the preparation of TAA-LNPs using poly(lacticco-glycolic acid) as a carrier material, which have good biocompatibility and biodegradability. Based on a systematic investigation of its physicochemical properties, a rabbit ear HSs model was established to evaluate the percutaneous permeability of TAA-LNPs in scar tissue in vitro as well as to assess its curative effect and skin irritation. Results: The results showed that the TAA-LNPs formed uniform and round particles under fluoroscopy and had a complex structure in which a nanoparticle core was surrounded by multiple vesicles. The particles were 232.2±8.2 nm in size, and the complimentary potential was-42.16 mV. The encapsulation efficiency was 85.24%, which is greater than that of other common liposomes and nanoparticles. A test of in vitro scar tissue permeability showed that penetration into scar tissue was twofold and 40-fold higher for TAA-LNPs than for common liposome and commercial suspensions, respectively. The concentration of the absorbed drug effectively inhibited fibroblast proliferation, achieved a therapeutic effect in HSs, and did not stimulate intact or damaged skin. Conclusion: The preparation of TAA into LNPs for transdermal administration can enhance transdermal permeation performance and the safety of this drug, which is beneficial for the treatment of HSs.

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Photodynamic therapy inhibits the formation of hypertrophic scars in rabbit ears by regulating metalloproteinases and tissue inhibitor of metalloproteinase-1

Abstract: PDT can induce senescence in fibroblasts, and may constitute a useful treatment for pathological scarring.

Cited by 17 publications

References 19 publications

Scarless wound healing: Transitioning from fetal research to regenerative healing

Scarless wound healing: Transitioning from fetal research to regenerative healing

Growth factor pathways in hypertrophic scars: Molecular pathogenesis and therapeutic implications

<p>Transdermal permeability of triamcinolone acetonide lipid nanoparticles</p>

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