Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system

Moghassemi, Saeid; Dadashzadeh, Arezoo; Azevedo, Ricardo Bentes; Féron, Olivier; Amorim, Christiani Andrade

doi:10.1016/j.jconrel.2021.09.024

Cited by 72 publications

(54 citation statements)

References 182 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study reported that ICG-loaded liposomes showed the same reduction in cancer cell viability compared with free ICG. 36,37 In comparison, the present MB-loaded FeCPC I : Na Ol MCV formulation in our work enhanced both the in situ 1 O 2 generation ability of MB and the in vitro phototoxicity against MCF-7 cells.…”

Section: Resultsmentioning

confidence: 63%

Metallocatanionic vesicle-mediated enhanced singlet oxygen generation and photodynamic therapy of cancer cells

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 63%

Metallocatanionic vesicle-mediated enhanced singlet oxygen generation and photodynamic therapy of cancer cells

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Among all, PDT is one of the best treatment modalities for skin cancer. Despite being non-invasive, PDT has a few limitations that restrict its application in cancer treatment, such as poor bioavailability, the unwanted side effect of some hydrophobic PSs, high dosage requirement, and self-aggregation in aqueous biological media due to the hydrophobic nature of most the PSs [ 59 ]. To improve the efficiency of PDT, nanocarriers can be used to encapsulate PSs and improve their bioavailability and stability.…”

Section: Photodynamic Therapy and Nanomedicine In Cancer Treatmentmentioning

confidence: 99%

Photo-Induced Drug Release from Polymeric Micelles and Liposomes: Phototriggering Mechanisms in Drug Delivery Systems

et al. 2022

View full text Add to dashboard Cite

Chemotherapeutic drugs are highly effective in treating cancer. However, the side effects associated with this treatment lower the quality of life of cancer patients. Smart nanocarriers are able to encapsulate these drugs to deliver them to tumors while reducing their contact with the healthy cells and the subsequent side effects. Upon reaching their target, the release of the encapsulated drugs should be carefully controlled to achieve therapeutic levels at the required time. Light is one of the promising triggering mechanisms used as external stimuli to trigger drug release from the light-responsive nanocarriers. Photo-induced drug release can be achieved at a wide range of wavelengths: UV, visible, and NIR depending on many factors. In this review, photo-induced release mechanisms were summarized, focusing on liposomes and micelles. In general, light-triggering mechanisms are based on one of the following: changing the hydrophobicity of a nanocarrier constituent(s) to make it more soluble, introducing local defects within a nanocarrier (by conformational transformation or photo-cleavage of its lipids/polymers chains) to make it more porous or concentrating heat for thermo-sensitive nanocarriers to release their payload. Several research studies were also presented to explore the potentials and limitations of this promising drug release triggering mechanism.

show abstract

“…Some of the pH-responsive liposomes provide numerous benefits in site-specific drug release ( Lee and Thompson, 2017 ). Liposomes are commonly used as a carrier molecule for the delivery of photosensitizers in cancer PDT applications ( Moghassemi et al, 2021 ). Liposomes have some drawbacks in drug delivery, including poor stability, low solubility, a short half-life, drug leakage and high production costs ( Leitgeb et al, 2020 ).…”

Section: Biocompatible Nanocarriers In Cancer Photodynamic Therapymentioning

confidence: 99%

Recent advances in the development of biocompatible nanocarriers and their cancer cell targeting efficiency in photodynamic therapy

Kumar

Abrahamse

2022

Front. Chem.

View full text Add to dashboard Cite

In recent years, the role of biocompatible nanocarriers (BNs) and their cancer cell targeting efficiency in photodynamic therapy (PDT) holds potential benefits for cancer treatment. Biocompatible and biodegradable nanoparticles are successfully used as carrier molecules to deliver cancer drugs and photosensitizers due to their material safety in the drug delivery system. Biocompatible nanocarriers are non-toxic and ensure high-level biocompatibility with blood, cells, and physiological conditions. The physicochemical properties of BNs often enable them to modify their surface chemistry, which makes conjugating specific ligands or antibodies to achieve cancer cell targeting drug delivery in PDT. This review article focuses on the various types of BNs used in targeted drug delivery, physicochemical properties, and surface chemistry of BNs in targeted drug delivery, advantages of BNs in drug delivery systems, and the targeting efficiency of BNs on some specific targeting receptors for cancer therapy. Furthermore, the review briefly recaps the nanocarrier-based targeted approaches in cancer PDT.

show abstract

Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system

Cited by 72 publications

References 182 publications

Metallocatanionic vesicle-mediated enhanced singlet oxygen generation and photodynamic therapy of cancer cells

Metallocatanionic vesicle-mediated enhanced singlet oxygen generation and photodynamic therapy of cancer cells

Photo-Induced Drug Release from Polymeric Micelles and Liposomes: Phototriggering Mechanisms in Drug Delivery Systems

Recent advances in the development of biocompatible nanocarriers and their cancer cell targeting efficiency in photodynamic therapy

Contact Info

Product

Resources

About