Metallocatanionic vesicle-mediated enhanced singlet oxygen generation and photodynamic therapy of cancer cells

Sharma, Bunty; Jain, Akhil; Pérez-García, Lluïsa; Watts, Julie A.; Rawson, Frankie J.; Chaudhary, Ganga Ram; Kaur, Gurpreet

doi:10.1039/d2tb00011c

Cited by 4 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As photosensitizers, many organic compounds were studied to produce singlet oxygen with high quantum yields (QY). Usually, these compounds are nanotubes, graphene derivatives, and diverse molecules with π-donors and π-acceptors in their structure to promote the charge transfer to the triplet state. − In comparison with the organic compounds, photosensitizers containing metal atoms used as 1 O 2 sensitizers are less studied and are mainly focused on metalloporphyrin, metal–organic framework (MOF), and nanoparticles. − …”

Section: Introductionmentioning

confidence: 99%

Heterometallic Au(I)–Cu(I) Clusters: Luminescence Studies and¹O₂Production

2023

View full text Add to dashboard Cite

Two different organometallic gold(I) compounds containing naphthalene and phenanthrene as fluorophores and 2-pyridyldiphenylphosphane as the ancillary ligand were synthesized (compounds 1 with naphthalene and 2 with phenanthrene). They were reacted with three different copper(I) salts with different counterions (PF6 –, OTf–, and BF4 –; OTf = triflate) to obtain six Au(I)/Cu(I) heterometallic clusters (compounds 1a–c for naphthalene derivatives and 2a–c for phenanthrene derivatives). The heterometallic compounds present red pure room-temperature phosphorescence in both solution, the solid state, and air-equilibrated samples, as a difference with the dual emission recorded for the gold(I) precursors 1 and 2. The presence of Au(I)–Cu(I) metallophilic contacts has been identified using single-crystal X-ray diffraction structure resolution of two of the compounds, which play a direct role in the resulting red-shifted emission with respect to the gold(I) homometallic precursors. Polystyrene (PS) and poly(methyl methacrylate) (PMMA) polymeric matrices were doped with our luminescent compounds, and the resulting changes in their emissive properties were analyzed and compared with those previously recorded in the solution and the solid state. All complexes were tested to analyze their ability to produce 1O2 and present very good values of ΦΔ up to 50%.

show abstract