Photochemical stabilization of block copolymer micelles

Wilson, D.; Riess, Gérard

doi:10.1016/0014-3057(88)90024-9

Cited by 49 publications

(35 citation statements)

References 23 publications

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“…A similar approach has been applied by Riess and co-workers [25] who studied the UV photocrosslinking process of polystyreneb-polybutadiene copolymer micelles in selective solvents. The investigation comprised a range of block copolymers differing in structure, composition, and molar mass.…”

Section: Introductionmentioning

confidence: 84%

Polyether nanoparticles from covalently crosslinked copolymer micelles

Jamróz-Piegza

Wałach

Dworak

et al. 2008

Journal of Colloid and Interface Science

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Section: Introductionmentioning

confidence: 84%

Polyether nanoparticles from covalently crosslinked copolymer micelles

Jamróz-Piegza

Wałach

Dworak

et al. 2008

Journal of Colloid and Interface Science

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“…However, for certain applications stabilization of self‐assembled structures via covalent crosslinking is desired. The most prominent methods employed for the covalent crosslinking of micellar structures are: the incorporation of a polymerizable6, 7 or photo/UV crosslinkable group8–12 and the introduction of crosslinking reagents (e.g. diamines) 8, 13–16.…”

Section: Introductionmentioning

confidence: 99%

Labelling cell structures and tracking cell lineage in zebrafish using SNAP-tag

et al. 2011

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We present a method for the specific labelling of fusion proteins with synthetic fluorophores in Zebrafish. The method uses the SNAP-tag technology and O 6 -benzylguanine derivatives of various synthetic fluorophores. We demonstrate how the method can be used to label subcellular structures in Zebrafish such as the nucleus, cell membranes, and endosomal membranes. The stability of the synthetic fluorophores makes them attractive choices for long-term imaging and allows, unlike most of the autofluorescent proteins, the use of acid fixatives such as trichloroacetic acid. Furthermore, the use of O 6 -benzylguanine derivatives bearing caged fluorescein allows cell lineage tracing through photo-deprotection of the fluorophore and its detection either through fluorescence microscopy or through immunohistochemistry after fixation using anti-fluorescein antibodies. Developmental Dynamics 240:820-827,

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“…In selective solvents, block copolymers can self‐assemble into various mesophases with diverse morphologies 1–6. To enhance the structural integrity of these supramolecular nanostructures such as block copolymer micelles, the methodology of covalent stabilization via core crosslinking7–12 or shell crosslinking13–20 have been extensively explored. The preparation of core‐crosslinked (CCL) micelles can be further categorized into two main strategies.…”

Section: Introductionmentioning

confidence: 99%

Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype

Sengupta

Chakrabarti

Roy

et al. 2007

Cancer

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BACKGROUND.A subset of head and neck squamous cell carcinoma (HNSCC) exhibits a microsatellite instability (MIN) phenotype. The authors correlated alterations in the mismatch‐repair genes human mutL homolog 1 (hMLH1) and human mutS homolog 2 (hMSH2) in primary head and neck squamous cell carcinoma (HNSCC) tumors and in samples of leukoplakia with the MIN phenotype.METHODS.One hundred twenty‐three paired HNSCC normal and tumor tissues and 27 leukoplakia samples were examined for hypermethylation of hMLH1 and hMSH2 promoters. The hypermethylation status of the tissues was confirmed by expression studies. Sixty‐three of 123 randomly selected tumors and all 27 leukplakia samples were genotyped with 8 microsatellite markers to determine MIN.RESULTS.Fifty percent of HNSCC tumors and 63% of leukoplakia samples harbored hypermethylation at either or both hMLH1 and hMSH2 promoters. Normal tissues adjacent to methylation‐positive tumors also demonstrated hypermethylation of both promoters at a high frequency (25%). A positive correlation between tobacco habit and promoter hypermethylation was observed (P = .001). A correlation was observed between MIN and the frequency of promoter hypermethylation in the leukoplakia samples, but no such trend was observed in the HNSCC tumors. It is noteworthy that patients who had a high frequency of MIN‐positive tumors exhibited hypermethylation in both the affected tissues and the adjacent normal tissues (P = .007). Patients with a tobacco habit who had promoter hypermethylation at both the affected tissues and the adjacent normal tissues had tumors that mostly were MIN positive (P = .047).CONCLUSIONS.The current results suggested that tobacco‐addicted individuals are more susceptible to promoter hypermethylation of hMLH1 and hMSH2 and that, if such hypermethylation occurs in the normal squamous epithelium of the head and neck region, then those tissues are likely to develop into tumors that involve the MIN pathway. Cancer 2007;109:703–12. © 2007 American Cancer Society.

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Photochemical stabilization of block copolymer micelles

Cited by 49 publications

References 23 publications

Polyether nanoparticles from covalently crosslinked copolymer micelles

Polyether nanoparticles from covalently crosslinked copolymer micelles

Labelling cell structures and tracking cell lineage in zebrafish using SNAP-tag

Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype

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