Polyether nanoparticles from covalently crosslinked copolymer micelles

Photo-irradiation paradigm: Mapping a remarkable facile technique used for advanced drug, gene and cell delivery

“…Although self assembled core-shell nanostructures have been widely used as carriers for various hydrophobic and amphiphilic drugs, photo-crosslinked micelles considerably offer a fast and stable formulation approach for drug encapsulation without affecting its physicochemical properties ( Table 2) [159]. This in vivo stability usually associated with prolonged plasma half-life and passive accumulation in the target tissues.…”

“…A more recent study was conducted by Saito and his co-workers to demonstrate the feasibility of long term micellar aggregate stability of photo-crosslinked micelle synthesized by UV-irradiation of thymine-functionalized cores at short wavelength range [160]. Other promising photo-cured example is poly(ethylene oxide)-b-poly(glycidol-co-glycidyl cinnamate) micelles [159]. That carrier conjugated cinnamate with the glycidol to add a hydrophobic character to the backbone structure to facilitate their self assembly during micellization as well as UV sensitive double bonds to gain the photo-responsive ability [159].…”

“…Other promising photo-cured example is poly(ethylene oxide)-b-poly(glycidol-co-glycidyl cinnamate) micelles [159]. That carrier conjugated cinnamate with the glycidol to add a hydrophobic character to the backbone structure to facilitate their self assembly during micellization as well as UV sensitive double bonds to gain the photo-responsive ability [159]. Comparative 1 H NMR analysis for the photo-treated and untreated formulation illustrates that the kinetic stability of the obtained carrier is predominantly due to photoirradiation [159].…”

“…That carrier conjugated cinnamate with the glycidol to add a hydrophobic character to the backbone structure to facilitate their self assembly during micellization as well as UV sensitive double bonds to gain the photo-responsive ability [159]. Comparative 1 H NMR analysis for the photo-treated and untreated formulation illustrates that the kinetic stability of the obtained carrier is predominantly due to photoirradiation [159]. With the same photo-responsive moiety Kim et al photo-irradiated PEG-b-poly(2-cinnamoyloxyethyl methacrylate)-b-poly(methyl methacrylate) micellar carrier [22].…”

Crosslinkable micelles from diblock amphiphilic copolymers based on vinylbenzyl thymine and vinylbenzyl triethylammonium chloride

“…reported an early work of diblock copolymer micelles with crosslinkable hydrophobic groups. Subsequently, several efforts have been made to improve the synthesis of PMs with crosslinkable core or corona, such as synthesizing polymeric segments with functional groups ready to crosslink upon UV irradiation …”