Synthesis and Characterization of Polymeric Nanogels

Amamoto, Yoshifumi; Otsuka, Hideyuki; Takahara, Atsushi

doi:10.1002/9783527610419.ntls0246

Cited by 5 publications

(5 citation statements)

References 135 publications

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“…Since 1986 when Pelton synthesized NIPAAm for the first time, it has become the most-reported water-based thermosensitive nanogel. Generally, the phase transition temperature of such nanogels is fitted by copolymerizing ionic monomers with NIPAAm. , Nanogels of NIPAAm are synthesized in a one-step polymerization procedure, in which a divinyl cross-linker copolymerizes enables polymer chains into a porous 3D nanospherical network …”

Section: Synthesis Methods Of Thermosensitive Npsmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

338

212

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Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

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Section: Synthesis Methods Of Thermosensitive Npsmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

338

212

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“…Crosslinking due to chemical interactions leads to permanent, stable and rigid link in the polymer network. Physical interactions are obtained by polymer chain entanglements or by physical interactions, such as: hydrogen bonds, electrostatic, van der Waals and hydrophobic interactions (Jen et al, 1996 ; Amamoto et al, 2011 ; Sood et al, 2016 ). While the chemical nanogels are difficult to change, in the physical nanogels the sol–gel transitions can precede as a result of the environment stimuli changes.…”

Section: Nanogel Preparation Techniquesmentioning

confidence: 99%

Basic concepts and recent advances in nanogels as carriers for medical applications

Neamţu¹,

Rusu²,

Diaconu³

et al. 2017

Drug Delivery

349

219

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Nanogels in biomedical field are promising and innovative materials as dispersions of hydrogel nanoparticles based on crosslinked polymeric networks that have been called as next generation drug delivery systems due to their relatively high drug encapsulation capacity, uniformity, tunable size, ease of preparation, minimal toxicity, stability in the presence of serum, and stimuli responsiveness. Nanogels show a great potential in chemotherapy, diagnosis, organ targeting and delivery of bioactive substances. The main subjects reviewed in this article concentrates on: (i) Nanogel assimilation in the nanomedicine domain; (ii) Features and advantages of nanogels, the main characteristics, such as: swelling capacity, stimuli sensitivity, the great surface area, functionalization, bioconjugation and encapsulation of bioactive substances, which are taken into account in designing the structures according to the application; some data on the advantages and limitations of the preparation techniques; (iii) Recent progress in nanogels as a carrier of genetic material, protein and vaccine. The majority of the scientific literature presents the multivalency potential of bioconjugated nanogels in various conditions. Today's research focuses over the overcoming of the restrictions imposed by cost, some medical requirements and technological issues, for nanogels' commercial scale production and their integration as a new platform in biomedicine.

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“…The methods for creating nanogels can be categorized depending on size, polymerization method, and nanometer scale. The procedures for preparing gels and controlling their nanostructures are detailed in this section [ 30 ].…”

Section: Nanotechnological Approachmentioning

confidence: 99%

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

Sindhu

Gupta

Wadhera

et al. 2022

Gels

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This study examined the most recent advancements in nanogel production and drug delivery. Phytochemistry is a discipline of chemistry that studies herbal compounds. Herbal substances have aided in the development of innovative remedies for a wide range of illnesses. Several of these compounds are forbidden from being used in medications due to broad medical characteristics and pharmacokinetics. A variety of new technical approaches have been investigated to ameliorate herbal discoveries in the pharmaceutical sector. The article focuses on the historical data for herb-related nanogels that are used to treat a variety of disorders with great patient compliance, delivery rate, and efficacy. Stimulus-responsive nanogels such as temperature responsive and pH-responsive systems are also discussed. Nanogel formulations, which have been hailed as promising targets for drug delivery systems, have the ability to alter the profile of a drug, genotype, protein, peptide, oligosaccharide, or immunogenic substance, as well as its ability to cross biological barriers, biodistribution, and pharmacokinetics, improving efficacy, safety, and patient cooperation.

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Synthesis and Characterization of Polymeric Nanogels

Abstract: The sections in this article are Introduction Synthesis of Polymeric Nanogels Chemical Nanogels Polymerization in Templates Crosslinked Micelles and Star Polymers Polymer Reaction of Linear Chain, Nanoparticles, and Nanocomplexes Physical Nanogels … Show more

Cited by 5 publications

References 135 publications

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Basic concepts and recent advances in nanogels as carriers for medical applications

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

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