Photobiomodulation improves motor response in patients with spinal cord injury submitted to electromyographic evaluation: randomized clinical trial

Silva, Fernanda Cordeiro da; Gomes, Andréa Oliver; Palácio, Paulo Roberto da Costa; Politti, Fabiano; Silva, Daniela de Fátima Teixeira da; Mesquita‐Ferrari, Raquel Agnelli; Fernandes, Kristianne Porta Santos; Bussadori, Sandra Kalil

doi:10.1007/s10103-018-2447-3

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…Several studies have shown that laser light with a wavelength of 810 nm is suitable for the treatment of SCI by PBM . Hence, we chose a corresponding laser as the therapeutic light source.…”

Section: Discussioncontrasting

confidence: 77%

“…In our study once open surgery in Bama miniature pigs for entire irradiation period might be practical in clinical situations. In previous study , the different irradiation methods such as percutaneous and intravascular irradiation and irradiation after repeated open surgery might cause different light penetration depth. Thus, the therapeutic effect in these studies could not be evaluated with the same standard.…”

Section: Discussionmentioning

confidence: 99%

“…Da Silva et al percutaneously irradiated the SCI sites of patients with near‐infrared light (808 nm, 120 mW and 983 J/cm 2 ). Subsequent electromyography analysis demonstrated that phototherapy can improve the locomotor function of SCI patients .…”

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation by diffusing optical fiber on spinal cord: A feasibility study in piglet model

Liang

Tao

Wang

et al. 2020

Journal of Biophotonics

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Photobiomodulation by diffusing optical fiber on spinal cord: A feasibility study in piglet model

Liang

Tao

Wang

et al. 2020

Journal of Biophotonics

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“…Studies involving an experimental model of spinal cord injury have demonstrated that both the red and infrared wavelengths have the potential to be an effective, non-invasive means of therapy, promoting axonal sprouting, an increased concentration of glial cells and nerve connections as well as improvements in function and sensitivity [ 12 , 13 ]. In a clinical trial involving individuals with spinal cord injuries, PBM exerted positive effects on motor function, especially during isotonic contraction of the stimulated muscles, which were assessed using electromyography (EMG) [ 14 ]. Thus, the combination of physical therapy and PBM is promising treatment for individuals with MMC.…”

Section: Introductionmentioning

confidence: 99%

Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study

et al. 2021

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Introduction Myelomeningocele is a severe type of spina bifida, resulting from improper closure of the neural tube. This condition drastically affects the structures of the spinal cord resulting in deficiencies. The combination of these deficiencies results in an overall decrease in mobility and functional participation amongst this population. Physiotherapy plays an essential role in rehabilitating people with MMC. The current literature shows that resources such as photobiomodulation (PBM) may support the rehabilitation of neurological conditions. The aim of the proposed study is to evaluate the effects of photobiomodulation (PBM) combined with physical therapy on functional performance in children with low lumbosacral myelomeningocele. Materials and methods This is a protocol randomized clinical blind study, that will include 30 individuals of both sexes, aged between 5 to 8 years, diagnosed with low and sacral lumbar myelomeningocele and capable of performing the sit-to-stand task. The participants will be randomly assigned into two treatment groups: PBM + physiotherapeutic exercises and sham PBM + physiotherapeutic exercises. Irradiation will be carried out with light emitting diode (LED) at a wavelength of 850 nm, energy of 25 J per point, 50 seconds per point and a power of 200 mW. The same device will be used in the placebo group but will not emit light. Muscle activity will be assessed using a portable electromyograph (BTS Engineering) and the sit-to-stand task will be performed as a measure of functioning. Electrodes will be positioned on the lateral gastrocnemius, tibialis anterior and rectus femoris muscles. The Pediatric Evaluation of Disability Inventory will be used to assess functional independence. Quality of life will be assessed using the Child Health Questionnaire—Parent Form 50. Changes in participation will be assessed using the Participation and Environment Measure for Children and Youth. The data will be analyzed with the aid of GraphPad PRISM. Discussion The results of this study can contribute to a better understanding of the effectiveness of PBM on functioning and quality of life in children with myelomeningocele. Clinical trial registration ClinicalTrials.gov Identifier: NCT04425330.

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“…Low-level laser therapy is one of the anti-inflammatory treatments that its usage to treat disease associated with inflammation has increased in recent years (12)(13)(14). Although there is not any complete protocol provided on this topic yet, the conducted researches have indicated that low-level laser is effective in the reduction of post-SCI complications (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Four Weeks of Low-Level Laser Radiation (660 nm) on Movement Recovery and Fibroblasts Invasion

et al. 2019

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Background: Despite the fact that many researches have been done in regards to spinal cord injury (SCI), it remains an undissolved problem that has an effect on the individual's life and society. It could be due to complicated events that occur after SCI. Inflammation is an important initiator for after SCI events and low-level laser (LLL), which is known as an anti-inflammatory agent. Objectives: The aim of this study is the evaluation effects of LLL on the fibroblast invasion, axon number, and functional recovery after SCI. Methods: Twenty-four adult male Wistar rats were randomly divided into three groups as control, SCI, SCI + laser. Thirty minutes after SCI that was induced by aneurysm clip LLL irritated for 45 seconds daily and continued for four weeks. Functional recovery by BBB score, fibroblast invasion by H&E, and Axons number by Bielschowsky silver staining was assessed. Results: The data indicated LLL therapy improved BBB score, increased axons number, and decreased fibroblasts invasion around cavity comparing to SCI animals (P < 0.001). Conclusions: Our result showed that the initiation LLL therapy, in a short time after SCI, could be effective in the reduction of SCI side effects and improved functional recovery.

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Photobiomodulation improves motor response in patients with spinal cord injury submitted to electromyographic evaluation: randomized clinical trial

Abstract: NCT 03031223.

Cited by 13 publications

References 16 publications

Photobiomodulation by diffusing optical fiber on spinal cord: A feasibility study in piglet model

Photobiomodulation by diffusing optical fiber on spinal cord: A feasibility study in piglet model

Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study

The Effect of Four Weeks of Low-Level Laser Radiation (660 nm) on Movement Recovery and Fibroblasts Invasion

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