Photoallergy and Photosensitivity

Storck, H

doi:10.1001/archderm.1965.01600110055012

Cited by 42 publications

(11 citation statements)

References 20 publications

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“…In predictive animal photoallergenicity testing it is not possible to explain how the complete photoantigen is formed in each case, i.e. whether by photoactivation of the hapten on the skin or whether by photoactivation of skin components (Storck, 1965;Pathak & Epstein, 1971;Jung, 1972). With respect to light absorption of different wavelength by the skin components and the test compounds a light source with a continuous spectrum of emission should be used.…”

Section: Discussionmentioning

confidence: 99%

Predictive animal testing for photocontact allergenicity

1980

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The purpose of this investigation was to establish a standardized animal model to predict the photoallergenic potential of new chemical compounds. In a first series of experiments the main factors influencing the induction of photoallergenicity were evaluated (induction concentration, pH of the test solution, pretreatment of the irradiation site with sodium lauryl sulphate, additional use of adjuvant injections and routes of administration). Osram Ultravitalux lamps were utilized for these studies. In a second series of experiments a Xenon 6000 W radiation source was used. Positive results were obtained with well known photosensitizers, as, for instance, the halogenated salicylanilides, as well as with so-called weak photoallergens (e.g. bithionol, sulphanilamide) by stimulating the animals' immune system with Freund's complete adjuvant. The photoallergenic compounds were at the same time tested for their contact allergenic potential in the optimization test. A standard procedure for the predictive photoallergenicity assay in guinea-pigs is proposed.

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Section: Discussionmentioning

confidence: 99%

Predictive animal testing for photocontact allergenicity

1980

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“…The spectrophotometric curves for the eluate of each of these spots is depicted in Fig 5. It can be readily seen that the curve for irradiated chloroquine lies approximately halfway between the control chloroquine and the Rf 52 irradiated chloroquine. 7. Spectral Shift With Other Drugs: (a) Method.…”

Section: Methodsmentioning

confidence: 99%

The "Spectral Shift" Phenomenon of Chloroquine

SAMS¹

1966

Arch Dermatol

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“…Photoallergic contact dermatitis is a cutaneous cell-mediated Type IV hypersensitivity reaction to exogenous drugs in the presence of radiant energy [49][50][51][52][53][54][55]. Wavelengths in the UVA range are mainly responsible for such photoallergic reactions.…”

Section: Pbotosensitivitymentioning

confidence: 99%