The "Spectral Shift" Phenomenon of Chloroquine

The Association of the Two Antimalarials Chloroquine and Quinacrine for Treatment-Resistant Chronic and Subacute Cutaneous Lupus erythematosus

“…The putative mechanisms include binding to DNA [15] or melanin [16], anti-inflammatory action by sta bilizing lysosomal membranes [17] or immunosuppressive effect by inhibiting antigen presentation [18,19], A simple sunscreening effect is very unlikely. The absorption spec trum of antimalarials lies predominantly outside the UVB range [20], In addition, the minimal erythema dose of UV light in normal as well as in light-sensitive patients is un changed during antimalarial therapy [21],…”