Photoageing shows histological features of chronic skin inflammation without clinical and molecular abnormalities

Bosset, Sophie; Bonnet, Mathilde; Barré, Patrick; Chalon, Aurélie; Kurfürst, Robin; Bonté, Frédéric; Schnebert, Sylvianne; Varlet, Béatrice Le; Nicolas, Jean‐François

doi:10.1046/j.1365-2133.2003.05456.x

Cited by 96 publications

(78 citation statements)

References 27 publications

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“…62, 63 Photo-aged skin exhibit histological features of chronic inflammation without significant evidence of clinical or molecular abnormalities. [64][65][66] Collagen is the body's most abundant protein. As the principle structural component of the dermis it confers strength and support to human skin.…”

Section: Dermismentioning

confidence: 99%

Introduction to skin aging

Tobin

2017

Journal of Tissue Viability

430

335

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Section: Dermismentioning

confidence: 99%

Introduction to skin aging

Tobin

2017

Journal of Tissue Viability

430

335

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“…Activation of apoptosis occurs in a pathway that involves caspase-7 [25]. Mast cells and macrophages are found in greater numbers in photo-aged skin and are also thought to be involved in its causative mechanism [26].…”

Section: Intrinsic Ageingmentioning

confidence: 99%

“…Histological examination has demonstrated that more infiltrating mononuclear cells are found in skin chronically exposed to the sun in comparison to protected skin [29]. While much more remains to be understood regarding the mechanisms through which a cascade of adverse health effects are induced by UV exposure, it is well known that photo-ageing, photocarcinogenesis and photo-immunosuppression are sequelae of UV exposure, particularly the UVA range (320-400 nm) [30].…”

Section: Intrinsic Ageingmentioning

confidence: 99%

Skin ageing and its treatment

Baumann¹

2007

The Journal of Pathology

532

477

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The effects of chronic sun exposure on skin are readily apparent when skin not typically exposed to the sun and skin regularly exposed to the sun are compared. While the sun is not the only aetiological factor in the dynamic process of skin ageing, it is the primary exogenous cause among several internal and environmental elements. Thus, photo-ageing, the main focus of this article, is a subset of extrinsic skin ageing. The influence of the sun in extrinsic skin ageing, as well as its role in potentially altering the normal course of intrinsic (also known as natural or cellular) ageing, is discussed. Telomeres, the specialized structures found at the ends of chromosomes, are believed to be integral to cellular ageing as well as in the development of cancer. The ageing process, both intrinsic and extrinsic, is also believed to be influenced by the formation of free radicals, also known as reactive oxygen species. The loss of collagen is considered the characteristic histological finding in aged skin. Wrinkling and pigmentary changes are directly associated with photo-ageing and are considered its most salient cutaneous manifestations. Such photodamage represents the cutaneous signs of premature ageing. In addition, deleterious consequences of chronic sun exposure, specifically various forms of photo-induced skin cancer, are also linked to acute and chronic sun exposure. The only known strategies aimed at preventing photo-ageing include sun avoidance, using sunscreens to block or reduce skin exposure to UV radiation, using retinoids to inhibit collagenase synthesis and to promote collagen production, and using anti-oxidants, particularly in combination, to reduce and neutralize free radicals.

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“…Skin photoaged by UV radiation displays multiple histological features that reflect chronic skin inflammation and connective tissue damage [1]. The dermal damage induced by UV is principally manifested as destruction of the dermal extracellular matrix (ECM), which is composed primarily of type I collagen, elastin, proteoglycans, and fibronectin [2].…”

Section: Introductionmentioning

confidence: 99%

Anti-photoaging effect of fermented rice bran extract on UV-induced normal skin fibroblasts

Seo

Jung

Song

et al. 2010

Eur Food Res Technol

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Rice bran contains various polyphenolic compounds with anti-oxidative activities, and it has long been known to inhibit melanogenesis. Cofermentation of rice bran with Lactobacillus rhamnosus and Saccharomyces cerevisiae significantly reduced the melanin synthesis of the resulting extract to B16F1 melanoma cells. However, anti-aging and anti-inflammatory effects of these fermented rice bran extracts (FRBEs) were not investigated. The objective of this work was to investigate the ability of FRBE to protect fibroblast cultures against ultraviolet B (UV-B)-induced damage in vitro. To study the effect of FRBE on collagen synthesis, human fibroblasts were treated with 0.1, 0.5, or 1% of FRBE or 25 lM of As-2p over 3 days. The morphological change of fibroblasts, secretion of IL-1a, and pro-MMP-1 levels were evaluated. The rate of cell growth was reduced upon exposure of fibroblasts to UV-B radiation (30 mJ/cm 2 ) and did not recover after FRBE treatment. FRBE did not induce morphological changes and necrosis in a dose-dependent manner.Immunohistochemistry confirmed increased collagen synthesis in a dose-dependent manner after UV-irradiated fibroblasts were treated with FRBE. FRBE treatment reduced the UV-B-induced release of IL-1a to levels found in non-irradiated controls. In fibroblasts subjected only to UV-B irradiation, the level of pro-MMP-1 increased approximately fourfold compared to non-irradiated cells. However, treatment with FRBE decreased the level of pro-MMP-1 to a level similar to that of As-2p treated cells; this result was confirmed by western blot analysis. This work indicates that FRBE can increase the synthesis of type I collagen, decrease the expression of MMP-1, and inhibit the production of IL-1a in UV-B irradiated human fibroblasts.

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Photoageing shows histological features of chronic skin inflammation without clinical and molecular abnormalities

Abstract: Collectively, these data show that chronic ultraviolet irradiation induces alterations of innate immune cells which are recruited in sun-exposed skin without being activated.

Cited by 96 publications

References 27 publications

Introduction to skin aging

Introduction to skin aging

Skin ageing and its treatment

Anti-photoaging effect of fermented rice bran extract on UV-induced normal skin fibroblasts

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