Photoactivated multifunctional nanoplatform based on lysozyme-Au nanoclusters-curcumin conjugates with FRET effect and multiamplified antimicrobial activity

Zhang, Ying; Yan, Hongjun; Su, Rixiang; Li, Peiyuan; Wen, Fangzhou; Lv, Yingbin; Cai, Jinyun; Su, Wei

doi:10.1016/j.jddst.2022.103548

Cited by 9 publications

(6 citation statements)

References 75 publications

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“…Numerous researches 54–57 have demonstrated that PDA has good biocompatibility and antimicrobial properties when irradiated at 808 nm. Cur can produce ROS under 405 nm light irradiation, effectively killing S. aureus and E. coli , two highly pathogenic bacteria 58–60 . Therefore, wavelengths at 808 nm and 405 nm were selected to investigate the PTT and PDT antimicrobial properties of Ti‐PDA‐Cur.…”

Section: Methodsmentioning

confidence: 99%

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Polydopamine‐curcumin coating of titanium for remarkable antibacterial activity via synergistic photodynamic and photothermal properties

Guo,

Li,

Zhang

et al. 2023

Photochem & Photobiology

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Combined photothermal therapy (PTT) and photodynamic therapy (PDT) has emerged as a novel and effective antibacterial strategy. In order to endow titanium (Ti) with antibacterial properties, the Ti‐PDA‐Cur composite was prepared using the excellent adhesion properties of polydopamine (PDA) to load curcumin (Cur) on the surface of Ti. The Ti‐PDA‐Cur coating can produce singlet oxygen (1O2) and heat under 405 + 808 nm light irradiation, which can effectively kill Staphylococcus aureus and Escherichia coli. Moreover, the cytotoxicity and hemolysis rate of Ti‐PDA‐Cur were low, indicating its good biocompatibility. Therefore, this study provided a new strategy for the development of new Ti implants.

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Section: Methodsmentioning

confidence: 99%

“…Cur can produce ROS under 405 nm light irradiation, effectively killing S. aureus and E. coli, two highly pathogenic bacteria. [58][59][60] Therefore, wavelengths at 808 nm and 405 nm were selected to investigate the PTT and PDT antimicrobial properties of Ti-PDA-Cur.…”

Section: The Selection Of the Specific Light Wavelengthsmentioning

confidence: 99%

Polydopamine‐curcumin coating of titanium for remarkable antibacterial activity via synergistic photodynamic and photothermal properties

Guo,

Li,

Zhang

et al. 2023

Photochem & Photobiology

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“…Non-covalent interactions are also an effective strategy for the functionalization of AuNCs. For example, through electrostatic interactions, lysozyme (Lys)-AuNCs-curcumin (Cur) couples can bind to bacteria for real-time imaging of bacteria with excellent antibacterial effects ( Zhang et al., 2022 ). In addition, the quantum yield of AuNCs was significantly improved by hardening the Au(I)-thiol salt shells with TOA cations ( Pyo et al., 2015 ).…”

Section: Justification Of Auncs For Bioimagingmentioning

confidence: 99%

Advances of gold nanoclusters for bioimaging

Zhang

Gao²,

Chen

et al. 2022

iScience

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“…As a result, the denaturation process of lysozyme can be reversed relatively easily, − endowing lysozyme with relatively high stability against denaturation. Lysozyme has already been used in the delivery of hydrophobic drugs. − Due to the smaller size, lysozyme with conjugated drugs accumulates less likely in the kidney . Lysozyme, conjugated either with gold or k-carrageenan, was able to encapsulate curcumin (CCM) and generate nanoparticles with enhanced antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

Mix and Shake: A Mild Way to Drug-Loaded Lysozyme Nanoparticles

Cao,

Tian,

et al. 2024

ACS Appl. Mater. Interfaces

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Biocompatible nanoparticles as drug carriers can improve the therapeutic efficiency of hydrophobic drugs. However, the synthesis of biocompatible and biodegradable polymeric nanoparticles can be time-consuming and often involves toxic solvents. Here, a simple method for protein-based stable drugloaded particles with a narrow polydispersity is introduced. In this process, lysozyme is mixed with hydrophobic drugs (curcumin, ellipticine, and dasatinib) and fructose to prepare lysozyme-based drug particles of around 150 nm in size. Fructose is mixed with the drug to generate nanoparticles that serve as templates for the lysozyme coating. The effect of lysozyme on the physicochemical properties of these nanoparticles is studied by transmission electron microscopy (TEM) and scattering techniques (e.g., dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS)). We observed that lysozyme significantly stabilized the curcumin fructose particles for 7 days. Moreover, additional drugs, such as ellipticine and dasatinib, can be loaded to form dual-drug particles with narrow polydispersity and spherical morphology. The results also reveal that lysozyme dual ellipticine/dasatinib curcumin particles enhance the cytotoxicity and uptake on MCF-7 cells, RAW 264.7 cells, and U-87 MG cells due to the larger and rigid hydrophobic core. In summary, lysozyme in combination with fructose and curcumin can serve as a powerful combination to form protein-based stable particles for the delivery of hydrophobic drugs.

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Photoactivated multifunctional nanoplatform based on lysozyme-Au nanoclusters-curcumin conjugates with FRET effect and multiamplified antimicrobial activity

Cited by 9 publications

References 75 publications

Polydopamine‐curcumin coating of titanium for remarkable antibacterial activity via synergistic photodynamic and photothermal properties

Polydopamine‐curcumin coating of titanium for remarkable antibacterial activity via synergistic photodynamic and photothermal properties

Advances of gold nanoclusters for bioimaging

Mix and Shake: A Mild Way to Drug-Loaded Lysozyme Nanoparticles

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