Polydopamine‐curcumin coating of titanium for remarkable antibacterial activity via synergistic photodynamic and photothermal properties

Abstract

Combined photothermal therapy (PTT) and photodynamic therapy (PDT) has emerged as a novel and effective antibacterial strategy. In order to endow titanium (Ti) with antibacterial properties, the Ti‐PDA‐Cur composite was prepared using the excellent adhesion properties of polydopamine (PDA) to load curcumin (Cur) on the surface of Ti. The Ti‐PDA‐Cur coating can produce singlet oxygen (1O2) and heat under 405 + 808 nm light irradiation, which can effectively kill Staphylococcus aureus and Escherichia coli. Moreover, the cytotoxicity and hemolysis rate of Ti‐PDA‐Cur were low, indicating its good biocompatibility. Therefore, this study provided a new strategy for the development of new Ti implants.

Enhancing the Biological Performance of Titanium Alloy through In Situ Modulation of the Surface Nanostructure: Near-Infrared-Responsive Antibacterial Function and Osteoinductivity

“…To further assess the antibacterial efficacy of the samples, live/dead staining was conducted. Live bacteria were visualized through green fluorescence, while dead cells were indicated by red fluorescence . As depicted in Figure a, under dark conditions, the bacteria cultured on Ti0, Ti12 HCl, Ti18 HCl, and Ti20 HCl appeared green, suggesting that these samples did not exhibit noticeable antibacterial activity.…”

“…Live bacteria were visualized through green fluorescence, while dead cells were indicated by red fluorescence. 50 As depicted in Figure 6a, under dark conditions, the bacteria cultured on Ti0, Ti12 HCl, Ti18 HCl, and Ti20 HCl appeared green, suggesting that these samples did not exhibit noticeable antibacterial activity. However, after 10 min exposure to NIR light, a greater number of dead cells were observed on Ti12 HCl, Ti18 HCl, and Ti20 HCl compared to Ti0, confirming their significant photodynamic antibacterial effects.…”