Photo Cross-linkable Biodendrimers as Ophthalmic Adhesives for Central Lacerations and Penetrating Keratoplasties

Degoricija, Lovorka; Johnson, C. Starck; Wathier, Michel; Kim, Terry; Grinstaff, Mark W.

doi:10.1167/iovs.06-0957

Cited by 51 publications

(49 citation statements)

References 29 publications

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“…In our ex vivo study the glue-sealed incisions were successful in preventing both the outflow and inflow of ink particles be- Table 1 Intraocular pressure (IOP) at which leaking was observed in three differents methods of side port incision sealing in a cadaveric human model Efficacy of three different methods for side port incision wound sealing fore and after the IOP challenge. These results strengthen the study by Degorcija et al that demonstrated the potential application of ocular adhesives in ophthalmologic procedures (27) . Our study also showed that after the IOP challenge the hydrosealed, sutured, and sutureless incisions showed a significant increase in the length of India ink penetration when compared with values observed at physiologic IOP.…”

Section: Discussionsupporting

confidence: 90%

Efficacy of three different methods for side port incision wound sealing

Kashiwabuchi¹,

Khan²,

Rodrigues³

et al. 2013

Rev. bras.oftalmol.

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RESUMOObjetivo: Avaliar o sinal de Seidel positivo e a penetração de tinta da Índia em incisões corneanas acessórias seladas por diferentes métodos. Métodos: Quatro incisões de 1,5 x 1,5mm foram criadas em cada um dos quatro olhos provindos do banco de olhos. Em cada córnea, uma incisão foi mantida sem manipulação, enquanto que as outras três incisões foram seladas respectivamente com Nylon 10-0, cola de cianoacrilato e hidratação estromal. Foram realizados dois testes: Sinal de Seidel positivo e penetração da tinta da Índia. No primeiro, foi aplicado fluoresceína gotas e a pressão intraocular (PIO) elevada de 15 para 80mmHg. No segundo, a tinta da Índia foi aplicada sobre o olho estudado em duas situações: sob PIO fisiológica e sob variação súbita da pressão, de 80 para 0mmHg. Resultados: Na incisão selada com cola, apesar da variação da PIO, não houve vazamento e nem penetração de partículas de tinta. Por outro lado, o sinal de Seidel foi positivo nas outras três incisões em diferentes níveis de PIO (p=0,013). A penetração da tinta da Índia ocorreu nestas três incisões sob pressão fisiológica e com maior extensão após a variação da PIO (p<0,05). Esta diferença, no entanto não foi considerada estatisticamente significante quando comparadas as incisões entre si. Conclusão: No presente estudo, a cola foi mais eficaz em prevenir Seidel e entrada de partículas do que outro método comumente usado especialmente, hidratação estromal.

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Section: Discussionsupporting

confidence: 90%

Efficacy of three different methods for side port incision wound sealing

Kashiwabuchi¹,

Khan²,

Rodrigues³

et al. 2013

Rev. bras.oftalmol.

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“…They have also demonstrated the use of the dendritic bio adhesive ([G1]-PGLSA-MA) 2 -PEG in numerous ocular applications including central corneal lacerations [143], clear corneal cataract incisions [144,145], flaps from LASIK surgery [146], scleral incisions [147] and 8-mm penetrating keratoplasties [148]. These in vitro studies tested the capability of this sealant to withstand high IOP (mean leakage pressure of 78.7 mmHg in lacerated cornea) [149].…”

Section: Photo-activated Dendritic Polymersmentioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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“…In addition, dendritic adhesives form a protective barrier that prevents fluid movement in and out of the wound and, as such, may act as a microbial barrier to infection. 9 The outcomes observed with the biodendrimer-based adhesive favor its use for the repair of corneal wounds caused by surgery, infection, or injury. "Self-gelling" biodendrimer adhesives, which do not require light, are currently being investigated and, when tested in vitro, performed satisfactorily.…”

Section: Histologic Resultsmentioning

confidence: 99%

“…2,9,10 This experiment was designed to test these biodendrimers in vivo and compare wound healing with that after traditional suture repair. We report herein the results of the first randomized prospective experiment, to our knowledge, to compare the clinical and histologic healing response of corneal lacerations repaired by either traditional suture or the argon ion laser-activated biodendrimer polymer ([G1]-PGLSA-MA) 2 -PEG in an in vivo chicken model.…”

Section: Ull-thickness Cornealmentioning

confidence: 99%

Comparison of Sutures and Dendritic Polymer Adhesives for Corneal Laceration Repair in an In Vivo Chicken Model

Berdahl

Johnson²,

Proia³

et al. 2009

Arch Ophthalmol

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To compare clinical and histologic healing of corneal lacerations repaired by sutures or a new polymeric adhesive.Methods: A central full-thickness 4.1-mm laceration was made in the right eyes of 60 white leghorn chickens. Half of the wounds were treated with biodendrimer polymer adhesive and half were closed with 3 interrupted 10-0 nylon sutures. Slitlamp examination was performed at 6 hours, daily for 7 days, and weekly for 21 days. Animals were humanely killed at days 1, 3, 7, and 28 for histologic examination to evaluate corneal healing.Results: Histologic observations on days 1, 3, and 7 showed glued wounds filled with fibrin, then hyperplastic epithelium, and subsequently scar tissue. Scarring was more prominent at day 7 in glued corneas; however, by day 28, sutured corneas exhibited more inflammation and scarring and much more irregular anterior corneal surfaces. Clinically, all glued corneas remained clear while nearly all sutured corneas had some degree of corneal scarring persisting through day 28. The procedure was about 5 times faster with sealant than with sutures. Conclusion:Corneal lacerations treated with adhesive heal favorably compared with sutures.Clinical Relevance: Biodendrimer adhesives represent a safe, effective, and technically easier alternative to traditional suture repair of corneal perforations.

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Photo Cross-linkable Biodendrimers as Ophthalmic Adhesives for Central Lacerations and Penetrating Keratoplasties

Cited by 51 publications

References 29 publications

Efficacy of three different methods for side port incision wound sealing

Efficacy of three different methods for side port incision wound sealing

Tissue adhesives in ocular surgery

Comparison of Sutures and Dendritic Polymer Adhesives for Corneal Laceration Repair in an In Vivo Chicken Model

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