Photo-contact dermatitis arising from the presence of quindoxin* in animal feeding stuffs

Scott, K.W.; Dawson, T. A. J.

doi:10.1111/j.1365-2133.1974.tb06450.x

Cited by 29 publications

(10 citation statements)

References 3 publications

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“…QUIN has been reported to induce contact as well as photocontact dermatitis, followed by persistent light reaction [30][31][32][33]. QUIN was withdrawn from the European Economic Community market in 1975 because of its carcinogenic properties in experimental animals, in particular, it induced the formation of nasal and hepatic tumors in rats [34].…”

Section: Growth-promoting Properties and Toxicity Of Quinoxaline 14-mentioning

confidence: 99%

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Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Carta

Corona²,

Loriga

2005

CMC

136

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Since 1940s, Quinoxaline 1,4-dioxides (QdNO's) are known as potent antibacterial agents, and subtherapeutic levels have been used to promote growth and improve efficiency of feed conversion in animal feed. They have also shown a selective cytotoxicity against hypoxic cells present in solid tumours. Furthermore, recent studies have put in evidence that QdNO's are endowed with antitubercular, antiprotozoal and anticandida activities. On the other hand, several authors have reported about photoallergic and mutagenic effects of some derivatives. QdNO's may also cause the development of antibiotic-resistant bacteria and influence the horizontal transfer of virulence genes between bacteria. In this review article we report the biological properties, the mode of action and Structure Activity Relationship (SAR) studies of the QdNO derivatives. Furthermore, some cytogenetic and genotoxic effects, classical and more recent method of synthesis, the quinoxaline 1,4-dioxides, and some of their most important reactions, were also reported.

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Section: Growth-promoting Properties and Toxicity Of Quinoxaline 14-mentioning

confidence: 99%

“…Symptoms of OLAQinduced photoallergy resemble those of QUIN [31]. Generally, a photochemical reaction of a xenobiotic resulting in damage of, or irreversible binding to an endogenous protein, is considered as an initial step, which may lead to a photoallergic response [39][40][41].…”

Section: Growth-promoting Properties and Toxicity Of Quinoxaline 14-mentioning

confidence: 99%

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Carta

Corona²,

Loriga

2005

CMC

136

View full text Add to dashboard Cite

show abstract

“…Quindoxin is a growth‐promoting agent used in animal foodstuffs. It has been reported to cause PACD in farm workers handling the feed (25,26). It is no longer used.…”

Section: Therapeutic Agentsmentioning

confidence: 99%

Photocontact dermatitis

DeLeo¹

2004

Dermatol Ther

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Photocontact dermatitis is not a common condition, but neither is it rare. Both photo-irritant contact dermatitis (PICD) and photoallergic contact dermatitis (PACD) are seen by most dermatologists in general practice. PICD is diagnosed on clinical grounds and is usually caused by furocoumarins in plants like limes and celery. PACD is caused primarily by sunscreens but can also be the result of fragrances and antibacterial agents. PACD can only be diagnosed by photo-patch testing that most dermatologists, even those who patch test and give phototherapy in their office, do not perform. The procedure as outlined in this manuscript is relatively simple and can easily be accomplished in the dermatologist's office.

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“…It has also been shown to be responsible for photocontact dermatitis in human subjects (Scott & Dawson, 1974). It has also been shown to be responsible for photocontact dermatitis in human subjects (Scott & Dawson, 1974).…”

Section: A Study Of Persistent Light Reaction In Quindoxin and Quininmentioning

confidence: 99%

Trichotillomania: a pathogenic interpretation of histologic changes in the pilosebaceous unit

Lachapelle¹,

Pierard²,

Fierens³

1975

Br J Dermatol

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Photo-contact dermatitis arising from the presence of quindoxin* in animal feeding stuffs

Abstract: Seventeen patients suffering from photo-contact dermatitis due to quindoxin sensitivity are described. The source of contact was animal feeding stuffs.

Cited by 29 publications

References 3 publications

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Photocontact dermatitis

Trichotillomania: a pathogenic interpretation of histologic changes in the pilosebaceous unit

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