Photo-based PDT/PTT dual model killing and imaging of cancer cells using phycocyanin-polypyrrole nanoparticles

Bharathiraja, Subramaniyan; Manivasagan, Panchanathan; Moorthy, Madhappan Santha; Bui, Nhat Quang; Jang, Bian; Phan, Thi Tuong Vy; Jung, Won‐Kyo; Kim, Young-Mok; Lee, Kang Dae

doi:10.1016/j.ejpb.2017.11.007

Cited by 54 publications

(28 citation statements)

References 30 publications

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“…As all therapeutic methods, PDT and PTT have limitations that need to be circumvented for broader use and improved therapeutic outcomes. One strategy to achieve this is to combine PDT with PTT, which seems to provide a synergistic effect ( Bharathiraja et al, 2018 ; Bilici et al, 2019 ; Wang et al, 2019 ; Xia et al, 2019 ). Practically, if this can be achieved with a single PS, clinical translation would be relatively easy.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Cyanine-Based Phototherapy Agents

et al. 2021

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Phototherapies, in the form of photodynamic therapy (PDT) and photothermal therapy (PTT), are very promising treatment modalities for cancer since they provide locality and turn-on mechanism for toxicity, both of which are critical in reducing off-site toxicity. Irradiation of photosensitive agents demonstrated successful therapeutic outcomes; however, each approach has its limitations and needs to be improved for clinical success. The combination of PTT and PDT may work in a synergistic way to overcome the limitations of each method and indeed improve the treatment efficacy. The development of single photosensitive agents capable of inducing both PDT and PTT is, therefore, extremely advantageous and highly desired. Cyanine dyes are shown to have such potential, hence have been very popular in the recent years. Luminescence of cyanine dyes renders them as phototheranostic molecules, reporting the localization of the photosensitive agent prior to irradiation to induce phototoxicity, hence allowing image-guided phototherapy. In this review, we mainly focus on the cyanine dye–based phototherapy of different cancer cells, concentrating on the advancements achieved in the last ten years.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in Cyanine-Based Phototherapy Agents

et al. 2021

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“…Photobased therapies such as photothermal therapy (PTT) and photodynamic therapy (PDT) have recently been developed as promising therapeutic strategies for antitumor therapy because of their minimal invasiveness, low side effects, and high specificity [1][2][3][4][5][6]. For PTT and PDT, they usually utilize the near-infrared (NIR) laser-induced capability of photothermal agents and photosensitizers (PSs) to generate heat or cytotoxic singlet oxygen ( 1 O 2 ), which subsequently causes cell apoptosis [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

Cai

Wang

et al. 2021

Research

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Near-infrared (NIR) laser-induced phototherapy through NIR agents has demonstrated the great potential for cancer therapy. However, insufficient tumor killing due to the nonuniform heat or cytotoxic singlet oxygen (1O2) distribution over tumors from phototherapy results in tumor recurrence and inferior outcomes. To achieve high tumor killing efficacy, one of the solutions is to employ the combinational treatment of phototherapy with other modalities, especially with chemotherapeutic agents. In this paper, a simple and effective multimodal therapeutic system was designed via combining chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) to achieve the polytherapy of malignant glioma which is one of the most aggressive tumors in the brain. IR-780 (IR780) dye-labeled tube-forming peptoids (PepIR) were synthesized and self-assembled into crystalline nanotubes (PepIR nanotubes). These PepIR nanotubes showed an excellent efficacy for PDT/PTT because the IR780 photosensitizers were effectively packed and separated from each other within crystalline nanotubes by tuning IR780 density; thus, a self-quenching of these IR780 molecules was significantly reduced. Moreover, the efficient DOX loading achieved due to the nanotube large surface area contributed to an efficient and synergistic chemotherapy against glioma cells. Given the unique properties of peptoids and peptoid nanotubes, we believe that the developed multimodal DOX-loaded PepIR nanotubes in this work offer great promises for future glioma therapy in clinic.

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“…DOX), which can improve the outcomes drastically since the synergistic effect between different therapy modalities increase the therapy efficiency compared to when they are used alone. On the other hand, since PAI depends on the same mechanism and is a NIR compatible diagnostic modality, it can also be combined with the therapeutical modalities such as PTT and PDT [36]. Similarly, drug release can be controlled by this heat generation utilizing the heat responsive drug entrapment strategies on the nanoparticles [8] so that chemotherapy can be combined and controlled with the NIR light triggered therapy modalities such as PTT and PDT.…”

Section: Introductionmentioning

confidence: 99%

Theranostic cancer applications utilized by nanoparticles offering multimodal systems and future insights

Yasun

2020

SN Appl. Sci.

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Recent studies showed that imaging-guided cancer therapeutics have higher success rates so instead of using a single modality, the combination of diagnosis and therapy (theranostic) modalities have simultaneously been employed more often for the cancer treatments. Also, instead of employing single modality, combination of more than one modality for each cancer diagnosis and therapy becomes to be the route for the scientists study in the field of theranostics and applied nanotechnology due to the improved theranostic efficiency. Purpose-oriented fabricated nanoparticles are usually chosen as carriers and contrast agents for those multimodal theranostic systems owing to their unique optoelectronic (optical-electronic) and physical properties. This is a mini review as a general synopsis of the recent applications of nanoparticles as one of the most efficient cancer theranostic agents and future insights for theranostics.

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Photo-based PDT/PTT dual model killing and imaging of cancer cells using phycocyanin-polypyrrole nanoparticles

Cited by 54 publications

References 30 publications

Recent Advances in Cyanine-Based Phototherapy Agents

Recent Advances in Cyanine-Based Phototherapy Agents

Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

Theranostic cancer applications utilized by nanoparticles offering multimodal systems and future insights

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