Phosphorylation in Coronary Artery Cold-Induced Contraction in the Newborn Lamb

Dahdah, Nagib; Russo, Pierantonio; Wagerle, L Craig

doi:10.1006/cryo.2001.2299

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…Additionally, expression of mRNA for various trophic factors and peptides, such as vascular endothelial growth factor [132] and endothelin [9], can be increased during cold storage, while their corresponding receptors may be concurrently downregulated, yielding no net increase in effect. In studies investigating hypothermic storage of lamb cerebral and coronary arteries, the low temperature appeared to increase tyrosine kinase phosphorylation of proteins [133,134]. These studies support the theory that many cell signaling pathways remain active even at low temperatures and can still be affected by trophic factors [126].…”

Section: Novel Trophic Factors For I/r Injurysupporting

confidence: 58%

Organ Preservation: Cryobiology and Beyond

Woods

Mullen

2016

Curr Stem Cell Rep

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Advances in surgical techniques, immunology, and organ donor networking have allowed organ transplantation to evolve over the last several decades into a procedure that has saved hundreds of thousands of lives. While these dramatic advances have made organ transplantation more effective, they have also highlighted the growing shortage of donor organs. Unfortunately, many organs that could be of potential use for transplantation end up discarded due to short preservation times, often only 4-12 h for vital organs. Organ preservation systems have been investigated with renewed vigor in attempts to solve this problem, and new tools are becoming available that make solutions much more possible than ever before. The cryobiology of organs must be understood for long-term banking solutions to be feasible, combined with greater understanding of the physio-chemical processes that take place during ischemia and reperfusion. New approaches based on natural models, stem cells, and various novel proteins and trophic factors all show great promise in accomplishing the goal of more donor organs matched with more patients in need.

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Section: Novel Trophic Factors For I/r Injurysupporting

confidence: 58%

Organ Preservation: Cryobiology and Beyond

Woods

Mullen

2016

Curr Stem Cell Rep

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“…In this work, we studied the effects of cooling on diazoxide‐induced vasodilation of calf cardiac vein and coronary artery, paying special attention to the role of nitric oxide in these responses. The calf cardiac vein and coronary artery are easily accesible smooth muscle preparations and there is limited information [14–16] about the effect of temperature in these vessels and the effects of cooling were generally studied with contractile agents. Furthermore, to our knowledge, there are no studies that analyze the effects of cooling on the diazoxide‐dependent relaxations.…”

Section: Discussionmentioning

confidence: 99%

Role of the nitric oxide on diazoxide‐induced relaxation of the calf cardiac vein and coronary artery during cooling

Atalık

Kılıç

Doğan

2009

Fundamemntal Clinical Pharma

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The effects of cooling (to 28 degrees C) on the vasodilation induced by diazoxide (10(-9)-3 x 10(-4) M) on carbachol-pre-contracted calf cardiac vein and coronary artery and the role of nitric oxide in these effects were analyzed. Diazoxide produced concentration-dependent relaxation of calf cardiac vein and coronary artery rings pre-contracted with carbachol (10(-6) M). During cooling, the pIC(50) values, but not the maximal responses, to diazoxide were significantly lower than at 37 degrees C in both preparations. Cooling to 28 degrees C in the presence of N(G)-nitro-L-arginine methyl ester (10(-4) M) did not modify the effect of temperature both in cardiac vein and coronary artery. These results suggest that cooling-induced changes of diazoxide in calf cardiac vein and coronary artery are independent of nitric oxide.

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“…Further, expression of mRNA for various trophic factors or other peptides, such as has been shown for vascular endothelial growth factor (21) and endothelin (22), can be increased during cold storage while receptors may be concurrently down‐regulated. Cold temperature has also been shown to increase tyrosine kinase phosphorylation of proteins in cold‐stored lamb cerebral and coronary arteries (23, 24). Thus, these studies have demonstrated that many cell signaling pathways retain activity at very low temperatures and can be affected by trophic factor administration; however, how these factors affect cell metabolism in the cold and the response to reperfusion remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Successful Six‐Day Kidney Preservation Using Trophic Factor Supplemented Media and Simple Cold Storage

McAnulty

Reid

Waller

et al. 2002

American Journal of Transplantation

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This study examined the effect of trophic factor supplementation [TFS; bovine neutrophil peptide-1 (bactenecin), 1 mg/L; substance P, 2.5 mg/L; nerve growth factor, 20 mg/L; epidermal growth factor, 10 mg/L; insulin-like growth factor-1, 10 mg/L] during cold storage with UW lactobionate solution. Dogs transplanted with kidneys stored for 4 days in TFS-UW had significantly lower peak serum creatinine values (mean 2.9 ∫ 0.2 mg/dL) and returned to normal values faster (6 days) than kidneys stored for 3 days in unmodified UW solution (4.2 ∫ 0.3 mg/dL and 14 days, respectively). Kidneys stored for 5 days in TFS-UW (mean peak creatinine 3.7 ∫ 0.3) functioned equivalently to kidneys stored for 3 days and better than kidneys stored for 4 days in UW alone. Dogs with kidneys stored for 6 days in TFS-UW had mean peak creatinines of 5.7 ∫ 0.4 mg/dL. These returned to normal creatinine values in 14 days, equal to 3-day stored and significantly better than kidneys stored for 4 days in UW alone (20 days recovery time). This study shows trophic factor deprivation appears to be a critical mechanism of injury in organ preservation with current synthetic storage media, and marks the initial development of a synthetic biologically active preservation solution, the next generation of preservation media.

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Phosphorylation in Coronary Artery Cold-Induced Contraction in the Newborn Lamb

Cited by 8 publications

References 18 publications

Organ Preservation: Cryobiology and Beyond

Organ Preservation: Cryobiology and Beyond

Role of the nitric oxide on diazoxide‐induced relaxation of the calf cardiac vein and coronary artery during cooling

Successful Six‐Day Kidney Preservation Using Trophic Factor Supplemented Media and Simple Cold Storage

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