Role of the nitric oxide on diazoxide‐induced relaxation of the calf cardiac vein and coronary artery during cooling

Atalık, Kısmet Esra Nurullahoğlu; Kılıç, Mehmet; Doğan, Necdet

doi:10.1111/j.1472-8206.2009.00671.x

Cited by 8 publications

(8 citation statements)

References 31 publications

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“…Moderate hypothermia, cooling to 25-31°C, has been shown to have a variable influence on the vascular sensitivity to various drugs and endogenous substances in different parts of the vascular system of animals (5). We have previously studied the thermal responses of smooth muscle in various vessels and observed that the sensitivity of different agents were temperature dependent (2,11). Thus, despite current research to determine the effects of temperature on vascular reactivity of different animal species, studies with human tissues remain incomplete.…”

Section: Introductionmentioning

confidence: 99%

Moderate hypothermia attenuates α1-adrenoceptor-mediated contraction in human varicose spermatic vein: The role of nitric oxide(Short communication)

Nurullahoglu-Atalik

Cenker²

2016

Acta Physiol Hung

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The effects of moderate hypothermia (28°C) on the response of human varicose spermatic vein to α 1 -adrenoceptor agonist phenylephrine and the role of endothelial nitric oxide (NO) in these effects were studied. Concentrationresponse curves for phenylephrine (10 −9 to 3 × 10 −4 M) were recorded in rings with and without endothelium at 37 and 28°C. To further analyze the role of NO, in the response to phenylephrine during hypothermia, the effects of this agonist in the presence of N G -nitro-L-arginine methyl ester (10 −4 M) were also determined. Under every condition tested, phenylephrine produced a marked, concentration-dependent contraction. Sensitivity of intact veins to the agonist was consistently lower at 28°C than at 37°C. There was no significant difference in phenylephrine response at 28 and 37°C in vessels without endothelium but at 28°C veins without endothelium showed a higher sensitivity than intact veins to phenylephrine. The sensitivity of veins with and without endothelium to nitroprusside (10 −9 to 3 × 10 −3 M) was significantly decreased during hypothermia, and endothelium removal did not affect the relaxation to this nitrovasodilator. These results suggest that moderate hypothermia decreases the sensitivity of human varicose spermatic vein to phenylephrine probably by increasing the availability of endothelial NO.

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Section: Introductionmentioning

confidence: 99%

Moderate hypothermia attenuates α1-adrenoceptor-mediated contraction in human varicose spermatic vein: The role of nitric oxide(Short communication)

Nurullahoglu-Atalik

Cenker²

2016

Acta Physiol Hung

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“…Coronary venous system (cardiac veins) collects one-third blood of the coronary circulation and is considered to be an important site for the blood-tissue exchange of water and nutrients, as well as a possible determinant of ventricular distensibility. The temperature utilized in this study; 28 °C, for cooling was considered to be "moderate cooling" and 41 °C, "moderate warming" temperature accordingly to previous studies (21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

The role of phosphodiesterase activity on the temperature-dependent responses of calf cardiac vein

Zu¹

2013

BLL

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Abstract:Objective: To evaluate the role of phosphodiesterase (PDE) activity in the cooling (to 28 °C) and warming (41 °C)-induced effects of carbachol on calf cardiac vein. Material and methods: Rings obtained from calf hearts were suspended in organ baths containing 25 ml of Krebs-Henseleit solution, maintained at 37 °C, continuously gassed with 95%O 2 -5%CO 2 . At the end of the resting period the preparations were contracted with carbachol (10 -9 -3x10 -4 M), at 37 °C. The same protocol was repeated at 28 °C and 41 °C after the preparations were allowed to equilibrate at this temperature for 60 min. In order to analyze the role of PDE activity in the cooling-and warming-induced vascular response, carbachol (10M) was applied in the presence of cilostazol (10 -6 M), IBMX (10 -6 M) and rolipram (10 -6 M), respectively. Results: The sensitivity of carbachol was signifi cantly lower during cooling, and higher during warming. Cooling to 28 and warming to 41 °C, after treatment with IBMX, cilostazol or rolipram, signifi cantly decreased the sensitivity to carbachol (p<0.05). Conclusion:The results of the present study suggest that PDE activity plays an essential role in cooling-and warming-induced changes of calf cardiac vein treated with carbachol (Tab. 1, Fig. 2

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“…Atalik et al [17] reported that cooling (28°C) did not attenuate sodium nitroprusside-induced relaxation in the calf coronary artery and cardiac vein with intact endothelium. Although the reason for this discrepancy is unclear, it seems possible that the coronary artery, but not the aorta, can function in response to NO even under hypothermia.…”

Section: Discussionmentioning

confidence: 99%

“…Atalik et al [17] investigated the effects of cooling (28°C) on the vasodilation induced by diazoxide on the carbachol-pre-contracted calf coronary artery and cardiac vein. They reported that pIC 50 values, but not maximal responses to diazoxide, were attenuated by cooling.…”

Section: Discussionmentioning

confidence: 99%

Direct effect of mild hypothermia on the coronary vasodilation induced by an ATP-sensitive K channel opener, a nitric oxide donor and isoflurane in isolated rat hearts

Tosaka

Cho

et al. 2010

J Anesth

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Purpose: Deliberate mild hypothermia (MHT) is applied for cerebroprotection after cardiopulmonary resuscitation and during cardiac surgery. MHT has been shown to alter both contractility and relaxation of blood vessels in the brain. However, the effects of MHT on drug-induced vasodilation are not fully understood. The aim of this study was to clarify the effects of MHT on the coronary vasodilation induced by cromakalim: an ATP-sensitive K channel opener, S-nitroso acetyl-penicillamine (SNAP): a nitric oxide donor, and isoflurane in isolated rat hearts.Methods: Male SD rat hearts were isolated and perfused with Krebs-Henseleit buffer.Coronary flow was measured with the coronary perfusion pressure kept at 60 mmHg, and coronary vascular resistance (CVR) was calculated. After cardiac arrest was induced by tetrodotoxin, the hearts were allocated to one of three temperature groups: 37, 34, and 31˚C (n = 7 for each). All groups received 0.01, 0.1, and 1.0 M of either cromakalim or SNAP or were exposed to isoflurane at 1MAC and 2MAC. Finally, 50 mM of adenosine was administered to obtain maximal coronary vasodilation.Results: CVR significantly increased after cardiac arrest, but did not change after application of each temperature. Cromakalim, SNAP and isoflurane significantly decreased CVR in each temperature group. There were no significant differences in CVR among the three temperature groups with any of the test drugs.

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Role of the nitric oxide on diazoxide‐induced relaxation of the calf cardiac vein and coronary artery during cooling

Cited by 8 publications

References 31 publications

Moderate hypothermia attenuates α1-adrenoceptor-mediated contraction in human varicose spermatic vein: The role of nitric oxide(Short communication)

Moderate hypothermia attenuates α1-adrenoceptor-mediated contraction in human varicose spermatic vein: The role of nitric oxide(Short communication)

The role of phosphodiesterase activity on the temperature-dependent responses of calf cardiac vein

Direct effect of mild hypothermia on the coronary vasodilation induced by an ATP-sensitive K channel opener, a nitric oxide donor and isoflurane in isolated rat hearts

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