Successful Six‐Day Kidney Preservation Using Trophic Factor Supplemented Media and Simple Cold Storage

McAnulty, Jonathan F.; Reid, Ted W.; Waller, Ken; Murphy, Christopher J.

doi:10.1034/j.1600-6143.2002.20805.x

Cited by 42 publications

(29 citation statements)

References 67 publications

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“…This approach resulted in an increase of animal survival rate after transplantation, and in the case of kidneys, this fact was observed even after 6-day organ preservation [150,151].…”

Section: Resultsmentioning

confidence: 99%

Organ Preservation: Current Concepts and New Strategies for the Next Decade

Guibert

Petrenko

Balaban

et al. 2011

Transfus Med Hemother

276

233

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Organ transplantation has developed over the past 50 years to reach the sophisticated and integrated clinical service of today through several advances in science. One of the most important of these has been the ability to apply organ preservation protocols to deliver donor organs of high quality, via a network of organ exchange to match the most suitable recipient patient to the best available organ, capable of rapid resumption of life-sustaining function in the recipient patient. This has only been possible by amassing a good understanding of the potential effects of hypoxic injury on donated organs, and how to prevent these by applying organ preservation. This review sets out the history of organ preservation, how applications of hypothermia have become central to the process, and what the current status is for the range of solid organs commonly transplanted. The science of organ preservation is constantly being updated with new knowledge and ideas, and the review also discusses what innovations are coming close to clinical reality to meet the growing demands for high quality organs in transplantation over the next few years.

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“…This approach resulted in an increase of animal survival rate after transplantation, and in the case of kidneys, this fact was observed even after 6-day organ preservation [150,151].…”

Section: Resultsmentioning

confidence: 99%

Organ Preservation: Current Concepts and New Strategies for the Next Decade

Guibert

Petrenko

Balaban

et al. 2011

Transfus Med Hemother

276

233

View full text Add to dashboard Cite

show abstract

“…393 In animal models, the addition of trophic factors to preservation solutions may also improve organ function immediately posttransplant. 394 For low-and normal-risk organs, cold storage may be suitable, but the time taken to reach 4°C and the low, yet persistent, level of metabolism at this temperature can cause tissue trauma in the absence of oxygen. Conversely, towards the end of cold storage, retrograde oxygen perfusion may actually reduce EAD.…”

Section: Donor Managementmentioning

confidence: 99%

Practical Recommendations for Long-term Management of Modifiable Risks in Kidney and Liver Transplant Recipients

et al. 2017

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Short-term patient and graft outcomes continue to improve after kidney and liver transplantation, with 1-year survival rates over 80%; however, improving longer-term outcomes remains a challenge. Improving the function of grafts and health of recipients would not only enhance quality and length of life, but would also reduce the need for retransplantation, and thus increase the number of organs available for transplant. The clinical transplant community needs to identify and manage those patient modifiable factors, to decrease the risk of graft failure, and improve longer-term outcomes. COMMIT was formed in 2015 and is composed of 20 leading kidney and liver transplant specialists from 9 countries across Europe. The group's remit is to provide expert guidance for the long-term management of kidney and liver transplant patients, with the aim of improving outcomes by minimizing modifiable risks associated with poor graft and patient survival posttransplant. The objective of this supplement is to provide specific, practical recommendations, through the discussion of current evidence and best practice, for the management of modifiable risks in those kidney and liver transplant patients who have survived the first postoperative year. In addition, the provision of a checklist increases the clinical utility and accessibility of these recommendations, by offering a systematic and efficient way to implement screening and monitoring of modifiable risks in the clinical setting. 12 Department of Gastroenterology and Hepatology, Erasmus MC, University Hospital Rotterdam, the Netherlands. 13 Department of Gastroenterology and Hepatology, University Hospitals KU Leuven, Belgium.14 Abdominal Transplant Surgery, Microbiology and Immunology Department, University Hospitals KU Leuven, Belgium. 15 Department of Hepatology and Liver Transplantation, Reina Sofía University Hospital, IMIBIC, CIBERehd, Spain. www.transplantjournal.com S1 S olid organ transplantation has evolved from an experimental procedure to an established treatment option for many types of end-stage organ failure. Both patient and graft outcomes are continuing to improve, and 1-year patient and graft survival currently exceed 80%.1,2 However, survival rates gradually decline over the long term. In kidney transplant, 5-and 10-year graft survival rates in Europe are 77% and 56%, and for liver transplant, 64% and 54% (Figures 1 and 2). 3,4 Although most European countries have seen an increase in both living and deceased donation, transplantation is not available to all who would benefit from the procedure, and there is considerable morbidity and mortality for those listed for transplant.6 Therefore, maximizing long-term graft survival and reducing the need for retransplantation is paramount, not only in improving outcomes for the recipients but also for those awaiting a graft. The improvement in outcomes is predominantly due to reduction in (Transplantation. 2017;101:S1-S41). The authors were approached by Astellas to discuss the practical implementation o...

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“…135 In animal models, the addition of trophic factors to preservation solutions improves organ function immediately posttransplant. 136 In human liver transplantation, the administration of a pan-caspase inhibitor to the preservation solution has been shown to result in lower transaminase levels. 137 Cold storage may be suitable for low-and normal-risk organs, but the time taken to reach 4°C and the low, yet persistent, level of metabolism at this temperature causes tissue trauma in the absence of oxygen.…”

Section: Early Allograft Dysfunction and Biliary Strictures After LIVmentioning

confidence: 99%