Phosphorene-gold nanocomposite based microfluidic aptasensor for the detection of okadaic acid

Ramalingam, Saipriya; Chand, Rohit; Singh, Chandra B.; Singh, Ashutosh

doi:10.1016/j.bios.2019.03.056

Cited by 99 publications

(33 citation statements)

References 32 publications

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“…As shown in the Fig. 3A, the CD spectrum of N59a without DTX-1 is similar to the characteristic CD spectrum of the i-motif structure under neutral conditions, 54 which might be due to that N59a forms an i-motif structure in this buffer. Aer the addition of DTX-1, the peak value of the CD spectrum was changed signicantly from statistical point of view.…”

Section: Analysis Of the Conformation Of N59asupporting

confidence: 51%

Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1

Zhou

et al. 2020

RSC Adv.

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Section: Analysis Of the Conformation Of N59asupporting

confidence: 51%

Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1

Zhou

et al. 2020

RSC Adv.

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“…Singh and coworkers have described the performances of an electrochemical microfluidic biochip to detect OA [ 55 ].…”

Section: Application Of Electrochemical Biosensors In Food Analysismentioning

confidence: 99%

Electrochemical Biosensors in Food Safety: Challenges and Perspectives

Curulli

2021

Molecules

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Safety and quality are key issues for the food industry. Consequently, there is growing demand to preserve the food chain and products against substances toxic, harmful to human health, such as contaminants, allergens, toxins, or pathogens. For this reason, it is mandatory to develop highly sensitive, reliable, rapid, and cost-effective sensing systems/devices, such as electrochemical sensors/biosensors. Generally, conventional techniques are limited by long analyses, expensive and complex procedures, and skilled personnel. Therefore, developing performant electrochemical biosensors can significantly support the screening of food chains and products. Here, we report some of the recent developments in this area and analyze the contributions produced by electrochemical biosensors in food screening and their challenges.

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“…As a result of the development of advanced technology and designing of selective artificial receptors, this is changing in recent years. One of the propositions for okadaic acid detection was presented in 2019 by Saipriya Ramalingam et al [ 167 ]. The authors developed an electrochemical microfluidic biochip for the detection of OA.…”

Section: Analytes For Nucleic Acids Aptamers In the Modern Medicalmentioning

confidence: 99%

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

Ziółkowski

Jarczewska

Górski

et al. 2021

Sensors

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This paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is followed by the description of the broad spectrum of aptamer-based sensors for the electrochemical detection of various diagnostically relevant analytes, including metal cations, abused drugs, neurotransmitters, cancer, cardiac and coagulation biomarkers, circulating tumor cells, and viruses. We described also possible future perspectives of aptasensors development. This concerns (i) the approaches to lowering the detection limit and improvement of the electrochemical aptasensors selectivity by application of the hybrid aptamer–antibody receptor layers and/or nanomaterials; and (ii) electrochemical aptasensors integration with more advanced microfluidic devices as user-friendly medical instruments for medical diagnostic of the future.

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Phosphorene-gold nanocomposite based microfluidic aptasensor for the detection of okadaic acid

Cited by 99 publications

References 32 publications

Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1

Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1

Electrochemical Biosensors in Food Safety: Challenges and Perspectives

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

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