Phospholipid-coated targeted microbubbles for ultrasound molecular imaging and therapy

Langeveld, Simone A. G.; Meijlink, Bram; Kooiman, Klazina

doi:10.1016/j.cbpa.2021.04.013

Cited by 18 publications

(14 citation statements)

References 63 publications

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“…Non-invasive imaging of pathophysiological events has recently been shown feasible with ultrasound due to the synthesis of functionalized microbubbles [56], i.e., microbubbles with one or more targeting moieties incorporated into the phospholipid encapsulation [57]. Due to the strictly intravascular nature of microbubbles, target sites have aimed at processes that occur within the vasculature, such as inflammation [58], angiogenesis [59], and thrombus formation [60].…”

Section: Molecularly Targeted Microbubblesmentioning

confidence: 99%

Ultrasound Contrast Imaging: Fundamentals and Emerging Technology

Yusefi

Helfield

2022

Front. Phys.

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The development of microbubble contrast agents has broadened the scope of medical ultrasound imaging. Along with dedicated imaging techniques, these agents provide enhanced echoes from the blood pool and have enabled diagnostic ultrasound to assess and quantify microvascular blood flow. Contrast-enhanced ultrasound is currently used worldwide with clinical indications in cardiology and radiology, and it continues to evolve and develop through innovative technological advancements. In this review article, we present an overview of the basic microbubble physics and bubble-specific imaging techniques that enable this modality, and follow this with a discussion on new and emerging applications.

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Section: Molecularly Targeted Microbubblesmentioning

confidence: 99%

Ultrasound Contrast Imaging: Fundamentals and Emerging Technology

Yusefi

Helfield

2022

Front. Phys.

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“…Microbubbles are clinical contrast agents for ultrasound imaging consisting of microsystems with sizes of ∼1-10 µm. Microbubbles have coatings that can be functionalized with ligands or targeting vectors, to create targeted systems recognizing biomarkers expressed in diseased tissues [117]. Magnetized microbubbles can be produced by incorporating MNPs in microbubbles' coating.…”

Section: Magnetic Microbubblesmentioning

confidence: 99%

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

et al. 2022

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Targeted delivery of pharmaceuticals is promising for efficient disease treatment and reduction in adverse effects. Nano or microstructured magnetic materials with strong magnetic momentum can be noninvasively controlled via magnetic forces within living beings. These magnetic carriers open perspectives in controlling the delivery of different types of bioagents in humans, including small molecules, nucleic acids, and cells. In the present review, we describe different types of magnetic carriers that can serve as drug delivery platforms, and we show different ways to apply them to magnetic targeted delivery of bioagents. We discuss the magnetic guidance of nano/microsystems or labeled cells upon injection into the systemic circulation or in the tissue; we then highlight emergent applications in tissue engineering, and finally, we show how magnetic targeting can integrate with imaging technologies that serve to assist drug delivery.

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“…Microbubbles have been used as ultrasound contrast agents, enhancing the nonlinear echoes and improving the contrast of vasculature in the acquired image. Pathophysiological ultrasound imaging has become possible thanks to the use of targeted microbubbles which can specifically adhere to the target molecule, such as P-selectin, VEGFR-2, and α v β 3 . − The microbubbles, however, can target only markers within the intravascular space because they are relatively large and confined to the vasculature. Therefore, developing targeted nanobubbles with several hundred nanometers, which can pass through the intercellular space, expands the biomedical application of ultrasound .…”

Section: Introductionmentioning

confidence: 99%

Concentration-Dependent Viscoelasticity of Poloxamer-Shelled Microbubbles

et al. 2022

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The oscillation of shelled microbubbles during exposure to ultrasound is influenced by the mechanical properties of the shell components. The oscillation behavior of bubbles coated with various phospholipids and other amphiphiles has been studied. However, there have been few investigations of how the adsorption conditions of the shell molecules relate to the viscoelastic properties of the shell and influence the oscillation behavior of the bubbles. In the present study, we investigated the oscillation characteristics of microbubbles coated with a poloxamer surfactant, that is, Pluronic F-68, at several concentrations after the adsorption kinetics of the surfactant at the gas−water interface had reached equilibrium. The dilatational viscoelasticity of the shell during exposure to ultrasound was analyzed in the frequency domain from the attenuation characteristics of the acoustic pulses propagated in the bubble suspension. At Pluronic F-68 concentrations lower than 2.0 × 10 −2 mol L −1 , the attenuation characteristics typically exhibited a sharp peak. At concentrations higher than 2.0 × 10 −2 mol L −1 , the peak flattened. The dilatational elasticity and viscosity of the shell were estimated by fitting the theoretical model to the experimental values, which revealed that both the elasticity and viscosity increased markedly at approximately 2.0 × 10 −2 mol L −1 . This suggests that the adsorption properties of Pluronic F-68 strongly affect the oscillation characteristics of microbubbles of a size suitable for medical ultrasound diagnostics.

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Phospholipid-coated targeted microbubbles for ultrasound molecular imaging and therapy

Cited by 18 publications

References 63 publications

Ultrasound Contrast Imaging: Fundamentals and Emerging Technology

Ultrasound Contrast Imaging: Fundamentals and Emerging Technology

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

Concentration-Dependent Viscoelasticity of Poloxamer-Shelled Microbubbles

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