Phosphoenolpyruvate metabolism in Teladorsagia circumcincta: A critical junction between aerobic and anaerobic metabolism

MAPK/ERK-PK(Ser11) pathway regulates divergent thermal metabolism of two congeneric oyster species

“…Previous studies have demonstrated that the metabolic regulation of PEP is a central hub for both aerobic and anaerobic metabolism. 39 , 40 , 41 PK, as a key enzyme controlling this balance, participates in aerobic and anaerobic metabolism under various stressors. On one hand, it promotes glycolysis and the TCA cycle to enhance energy production in aerobic metabolism.…”

Recent Advances in Elucidating Nematode Moulting – Prospects of Using Oesophagostomum dentatum as a Model

“…PEPCK has been identified previously in several parasitic nematode species (Davila et al, 2006;Geary et al, 1993;Hewitson et al, 2011;Iglesias et al, 2005;Klein et al, 1992;Mulvenna et al, 2009;Rios and Nowak, 2002;Rohrer et al, 1986;Simcock et al, 2012) and mainly functions in anaerobic respiration by the carboxylation of phosphoenolpyruvate to oxaloacetate, thereby introducing the products of glycolysis into mitochondrial metabolism (Saz and Lescure, 1969). PEPCK is essential for the anaerobic metabolism in gastrointestinal nematodes, and the energy obtained is required during the moulting process.…”

“…Therefore, changes in expression of specific collagen genes or key enzymes in the collagen biosynthetic pathway in the free-living nematode Caenorhabditis elegans results in significant defects in body shape, larval viability and/or moulting (e.g. Edens et al, 2001;Frand et al, 2005;Rual et al, 2004;Simmer et al, 2003;Page and Johnstone, 2007).…”