Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure–activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity

Ochiai, Koji; Takita, Satoshi; Eiraku, Tomohiko; Kojima, Akihiko; Iwase, Kazuhiko; Kishi, Tohru; Fukuchi, Kazunori; Yasue, Tokutaro; Adams, David H.; Allcock, Robert W.; Jiang, Zhong Tao; Kohno, Yasushi

doi:10.1016/j.bmc.2012.01.033

Cited by 42 publications

(19 citation statements)

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“…DME25 has been reported to have an inhibitory effect on the phosphorylation of the FAK pathway, while treatment with a FAK inhibitor significantly enhanced the effect of DME25 on the FAK pathway [241]. YZX has also demonstrated the ability to not only inhibit the growth of colorectal cancer cells and lung cancer cells but also to suppress the formation of mouse peritoneal tumor nodules in vivo.…”

Section: Yangzheng Xiaojimentioning

confidence: 99%

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

Jiang

Sanders

Katoh³

et al. 2015

Seminars in Cancer Biology

429

295

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Cancer is a key health issue across the world, causing substantial patient morbidity and mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to distant sites, with metastatic diseases accounting for a vast percentage of cancer patient mortality. While advances in this area have been made, the process of cancer metastasis and the factors governing cancer spread and establishment at secondary locations is still poorly understood. The current article summarizes recent progress in this area of research, both in the understanding of the underlying biological processes and in the therapeutic strategies for the management of metastasis. This review lists the disruption of E-cadherin and tight junctions, key signaling pathways, including urokinase type plasminogen activator (uPA), phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene (PI3K/AKT), focal adhesion kinase (FAK), β-catenin/zinc finger E-box binding homeobox 1 (ZEB-1) and transforming growth factor beta (TGF-β), together with inactivation of activator protein-1 (AP-1) and suppression of matrix metalloproteinase-9 (MMP-9) activity as key targets and the use of phytochemicals, or natural products, such as those from Agaricus blazei, Albatrellus confluens, Cordyceps militaris, Ganoderma lucidum, Poria cocos and Silybum marianum, together with diet derived fatty acids gamma linolenic acid (GLA) and eicosapentanoic acid (EPA) and inhibitory compounds as useful approaches to target tissue invasion and metastasis as well as other hallmark areas of cancer. Together, these strategies could represent new, inexpensive, low toxicity strategies to aid in the management of cancer metastasis as well as having holistic effects against other cancer hallmarks.

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Section: Yangzheng Xiaojimentioning

confidence: 99%

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

Jiang

Sanders

Katoh³

et al. 2015

Seminars in Cancer Biology

429

295

View full text Add to dashboard Cite

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“…Subsequently, the interaction between integrins and the cell cytoskeleton system is triggered (76). It has been reported that DME25 exhibited an inhibitory effect on the phosphorylation of the FAK pathway, and that the addition of a FAK inhibitor significantly enhanced the effect of DME25 on the FAK pathway (77). In addition, it was revealed that YZXJ not only inhibited the growth of colorectal and lung cancer cells, but also suppressed the formation of mouse peritoneal tumour nodules in an in vivo study.…”

Section: Tcm Regulates the Adhesion And Motility Of Cancer Cellsmentioning

confidence: 99%

Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis

Jia

et al. 2015

Oncology Letters

120

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Abstract. Traditional Chinese medicine (TCM) has been a major part of healthcare in China, and has extensively affected medicine and healthcare in surrounding countries over a long period of time. In the fight against cancer, certain anticancer remedies using herbs or herbal formulas derived from TCM have been developed for the management of malignancies. Furthermore, there are clinical trials registered for the use of herbal remedies in cancer management. Herbal medicine has been used as part of combined therapies to reduce the side-effects of chemotherapy, including bone marrow suppression, nausea and vomiting. Herbal remedies have also been used as chemopreventive therapies to treat precancerous conditions in order to reduce the incidence of cancer in high-risk populations. Emerging evidence has revealed that herbal remedies can regulate the proliferation, apoptosis, adhesion and migration of cancer cells. In addition to this direct effect upon cancer cells, a number of herbal remedies have been identified to suppress angiogenesis and therefore reduce tumour growth. The inhibition of tumour growth may also be due to modifications of the host immune system by the herbal treatment. However, the precise mechanisms underlying the therapeutic effects of herbal remedies remain poorly understood and are yet to be fully elucidated. The present study aims to summarize the current literature and clinical trial results of herbal remedies for cancer treatment, with a particular focus on the recent findings and development of the Yangzheng Xiaoji capsule.

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“…The nitration of N ‐(3‐methoxyphenyl)acetamide ( 12 ) also afforded the undesired N ‐(5‐methoxy‐2‐nitrophenyl)acetamide ( 14 ) as a major product rather than 13 (Scheme ). We then adopted a functional group transformation approach starting with 3‐methoxy‐2‐nitrobenzoic acid ( 5 ) that was converted to a Boc‐protected aniline derivative ( 15 ) (Scheme ). The N ‐deprotection of 15 afforded 3‐methoxy‐2‐nitroaniline ( 16 ) that on a Sandmeyer type reaction gave the corresponding bromo derivative 17 .…”

Section: Methodsmentioning

confidence: 99%