Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis

Ye, Lin; Jia, Yongning; Ji, Ke; Sanders, Andrew; Xue, Kan; Ji, Jiafu; Mason, Malcolm David; Jiang, Wen Guo

doi:10.3892/ol.2015.3459

Cited by 115 publications

(77 citation statements)

References 83 publications

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“…This aspect is specifically strengthened by the data that extracts from herbs selectively efficacious for the ER-F or ER-NF phenotype function via distinct effects on cell cycle progression, cellular apoptosis and formation of anti-proliferative E2 metabolites. Furthermore, the models developed and the results obtained in the present study provide relevant significance to the herbal management of ER + or ER -clinical breast cancer, as well to the relapse of ER + breast cancer, in which the ER expression has become negative (4,5,26,27,30). Clearly, clinical usefulness of the nutritional herbs investigated in the present study will have to be established in future human studies.…”

Section: Er-nf Er-f -------------------------------------------------mentioning

confidence: 79%

Inhibitory effects of Chinese nutritional herbs in isogenic breast carcinoma cells with modulated estrogen receptor function

Telang¹,

Guo²,

Katdare

et al. 2016

Oncology Letters

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Abstract. In estrogen receptor (ER)+ MCF-7 cells, ER represents a ligand-activated transcription factor, and 17β-estradiol (E2) represents its physiological ligand. Maintenance of the human breast carcinoma-derived MCF-7 cells with 0.7% serum selected a proliferative sub-population of E2-responsive cells with transiently non-functional ER due to limited availability of E2. Culture of MCF-7 cells in the presence of either 0.7% serum, <1 nM E2 or 0.7% serum + 20 nM E2 selected isogenic cells with either

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Section: Er-nf Er-f -------------------------------------------------mentioning

confidence: 79%

Inhibitory effects of Chinese nutritional herbs in isogenic breast carcinoma cells with modulated estrogen receptor function

Telang¹,

Guo²,

Katdare

et al. 2016

Oncology Letters

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“…That increases the side effects and toxicity and often restricts effectiveness. [18,19] In the clinical scenario, combined anticancer drugs are frequently used in cancer chemotherapy in order to minimize problems related to standard single-drug treatment. [15] The literature shows that natural products have excelled in cancer therapy due to their synergistic actions with antineoplastic drugs against various types of cancer.…”

Section: Resultsmentioning

confidence: 99%

Antitumour effects of the essential oil from Mentha x villosa combined with 5‐fluorouracil in mice

Amaral

Andrade

Dória

et al. 2016

Flavour & Fragrance J

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In the previous study, we demonstrated that the essential oil from the leaves of Mentha x villosa (EOMV) shows antitumour activities. In the present paper, the effects of the combination of 5-fluorouracil (5-FU) with the EOMV were determined in mice transplanted with Sarcoma 180 tumour cells. Hematological and biochemical analyses, as well as morphological analyses of the tumour and the organs (liver, spleen and kidney) were performed in order to evaluate the toxicological aspects. The combination of the EOMV (50 and 100 mg/kg/day) with 5-FU (10 mg/kg/day) led to a higher tumour growth inhibition rate (58.9% and 65.7%, respectively) when compared with 5-FU alone at 10 mg/kg/day (30.2%). The combined use of 5-FU (10 mg/ kg/day) with the EOMV (50 and 100 mg/kg/day) showed similar tumour growth inhibition rate to that of 5-FU alone at the highest dose (25 mg/kg/day) with less severe leukopenia. However, neither the enzymatic activity of transaminases nor the urea and creatinine levels were modified when compared with the 5-FU groups. These findings indicate that the EOMV may enhance the therapeutic effectiveness of chemotherapeutic drugs.

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“…Nutritional herbs are commonly used in herbal formulations for the treatment of breast cancer patients (7)(8)(9)37). Thus, preliminary evidence suggests that in the present triple negative model, nutritional herbs Tabebiua avellandae, Cornus officinalis and Dipsacus asperoides confer growth inhibitory effects via the RB pathway, and pro-apoptotic effects via the intrinsic mitochondrial BAX and caspase pathways (19)(20)(21).…”

Section: Biomarkermentioning

confidence: 89%

Growth inhibitory efficacy of natural products in a model for triple negative molecular subtype of clinical breast cancer

Telang¹

2017

Biomedical Reports

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Abstract. Global gene expression profiling identifies predictive and prognostic biomarkers and rationalizes breast cancer subtype-targeted treatment. The Anthracyclin/Taxol and survival pathway specific small molecular inhibitors, constitute current treatment options. These options are associated with acquired tumor resistance and emergence of drug-resistant cancer stem cells. Dietary supplements and constitutive bioactive phytochemicals with relatively low systemic toxicity may provide testable alternatives for current therapy. Human breast epithelial cell lines 184-B5 (non-tumorigenic triple negative cell type) and MDA-MB-231 (breast carcinoma derived triple negative cell type) were used as the experimental models. Putative cancer chemo-preventive natural products and their constitutive bioactive agents represented the test agents. Anchorage independent growth, cell cycle progression and cell apoptosis quantified the treatment efficacy. Compared to the 184-B5 cells, the MDA-MB-231 cells exhibited anchorage-independent growth indicative of persistent cancer risk. Additionally, the MDA-MB-231 cells exhibited hyper-proliferation, accelerated cell cycle progression and inhibited apoptosis indicative of loss of homeostatic growth control. The test agents inhibited anchorage-independent growth via cytostatic and pro-apoptotic effects. The triple negative carcinoma-derived Doxorubicin-resistant phenotype exhibited cancer stem cell markers, including tumor spheroid formation and expression of CD44, NANOG and c-Myc. These data identify clinically relevant mechanistic leads for the efficacy of natural products in the aggressive therapy-resistant breast cancer subtype and suggests a testable approach for cancer stem cell-targeted therapy.

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Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis

Cited by 115 publications

References 83 publications

Inhibitory effects of Chinese nutritional herbs in isogenic breast carcinoma cells with modulated estrogen receptor function

Inhibitory effects of Chinese nutritional herbs in isogenic breast carcinoma cells with modulated estrogen receptor function

Antitumour effects of the essential oil from Mentha x villosa combined with 5‐fluorouracil in mice

Growth inhibitory efficacy of natural products in a model for triple negative molecular subtype of clinical breast cancer

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