Synthesis and Cytotoxicity of (±)‐9‐Hydroxy‐5‐oxo‐2,3,4,5‐tetrahydro‐1H‐benzo[b]azepine‐2‐carboxamide: An Active Component of Juglans regia

Abstract

A total synthesis of a benzazepine natural product [1] was achieved via an alternative strategy using a Strecker-type synthesis/Heck coupling process to construct the core ring. A comparison of spectral data of the target molecule with the previously reported one suggested the need for structure revision. The compound described herein also showed cytotoxic properties.