Phloroglucinol derivatives from four Hypericum species belonging to the Trigynobrathys section

Supercritical fluid extraction and high performance liquid chromatographic determination of benzopyrans and phloroglucinol derivative in Hypericum polyanthemum

“…The dimeric compounds frequently present a benzopyran nucleus formed by the cyclization of the prenyl unit with an adjacent hydroxyl group. Together with these dimeric compounds, some species, such as H. polyanthemum, also present the benzopyran nucleus found as monomers [1,2]. Therefore, such difference in the composition of the lipophilic fraction may account for specific extraction conditions of the plant studied in this work.…”

“…Among them, Hypericum polyanthemum showed in its lipophilic extract the presence of uliginosin B, a phloroglucinol derivative, and three benzopyrans: 6-isobutyryl-5,7-dimethoxy-2,2-dimethylbenzopyran (HP1), 7-hydroxy-6-isobutyryl-5-methoxy-2,2-dimethyl-benzopyran (HP2) and 5-hydroxy-6-isobutyryl-7-methoxy-2,2-dimethylbenzopyran (HP3), isolated from aerial plant parts [1,2]. These substances have been found to be involved with some biological properties as antiviral [3], antimicrobial [4], antinociceptive [5], antitumor [6,7], acaricidal [8] and antioxidant [9], presented by the plant extracts.…”

Study of antidepressant-like activity of an enriched phloroglucinol fraction obtained fromHypericum caprifoliatum

“…In southern Brazil, 20 Hypericum species have been identified (Dall'Agnol et al, 2003); these species are rich in flavonoids and dimeric phloroglucinols conjugated with a filicinic acid moiety (Ferraz et al, 2002). These phloroglucinol derivatives were proposed as chemotaxonomic markers for the southern Brazilian species (Nör et al, 2004). Among the species studied, Hypericum caprifoliatum Cham & Schlecht showed promising results in the forced swimming test (FST), which predicts antidepressant activity (Daudt et al, 2000;Viana et al, 2005Viana et al, , 2008.…”

Supercritical extraction of phloroglucinol and benzophenone derivatives from Hypericum carinatum: Quantification and mathematical modeling

“…The dimeric phloroglucinol uliginosin B, previously isolated from some Hypericum species native to south Brazil (i.e. H. myrianthum, H. polyanthemum and H. carinatum) [2], demonstrated important antinociceptive effect [3]. H. carinatum also afforded the benzophenone derivatives cariphenone A and cariphenone B [4], whose chemical class has been highlighted for the cytotoxic and HIV-inhibitory activities [5][6][7].…”