The aim of our study was to evaluate the influence of surgical
removal of pheochromocytoma on the endocrine function of
adipose tissue and subclinical inflammation as measured by
circulating C-reactive protein (CRP) levels. Eighteen patients with
newly diagnosed pheochromocytoma were included into study.
Anthropometric measures, biochemical parameters, serum CRP,
leptin, adiponectin and resistin levels were measured at the time
of diagnosis and six months after surgical removal of
pheochromocytoma. Surgical removal of pheochromocytoma
significantly increased body weight, decreased both systolic and
diastolic blood pressure, fasting blood glucose and glycated
hemoglobin levels. Serum CRP levels were decreased by 50 % six
months after surgical removal of pheochromocytoma (0.49±0.12
vs. 0.23±0.05 mg/l, p<0.05) despite a significant increase in
body weight. Serum leptin, adiponectin and resistin levels were
not affected by the surgery. We conclude that increased body
weight in patients after surgical removal of pheochromocytoma is
accompanied by an attenuation of subclinical inflammation
probably due to catecholamine normalization. We failed to
demonstrate an involvement of the changes in circulating leptin,
adiponectin or resistin levels in this process.