The effect of pheochromocytoma treatment on subclinical inflammation and endocrine function of adipose tissue

Abstract

The aim of our study was to evaluate the influence of surgical removal of pheochromocytoma on the endocrine function of adipose tissue and subclinical inflammation as measured by circulating C-reactive protein (CRP) levels. Eighteen patients with newly diagnosed pheochromocytoma were included into study. Anthropometric measures, biochemical parameters, serum CRP, leptin, adiponectin and resistin levels were measured at the time of diagnosis and six months after surgical removal of pheochromocytoma. Surgical removal of pheochromocytoma significantly increased body weight, decreased both systolic and diastolic blood pressure, fasting blood glucose and glycated hemoglobin levels. Serum CRP levels were decreased by 50 % six months after surgical removal of pheochromocytoma (0.49±0.12 vs. 0.23±0.05 mg/l, p<0.05) despite a significant increase in body weight. Serum leptin, adiponectin and resistin levels were not affected by the surgery. We conclude that increased body weight in patients after surgical removal of pheochromocytoma is accompanied by an attenuation of subclinical inflammation probably due to catecholamine normalization. We failed to demonstrate an involvement of the changes in circulating leptin, adiponectin or resistin levels in this process.

Insulin Secretion and Insulin Sensitivity Before and After Surgical Treatment of Pheochromocytoma or Paraganglioma

“…Although the subgroup analysis revealed that the rates of improvement of parameters for insulin secretion and insulin sensitivity were not significantly different between the shorter and the longer time groups, these results do not completely excluded the possibility that long periods of time exerted some influence. BMI was slightly but significantly reduced after surgery, whereas the resection of pheochromocytoma or paraganglioma can lead to an increase in body mass through amelioration of the hypermetabolic condition (23)(24)(25). Furthermore, although the number of subjects in our study is larger than that in any previous similar study, it is still relatively small.…”

The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas

“…This leads to the expectation that they have a low immunogenic antigen density and minimal inflammation ( Farhat et al 2019 , Jimenez et al 2020 ). However, patients with hormonally active PPGLs in situ have been shown to have raised systemic inflammatory markers ( Zelinka et al 2007 , Bosanska et al 2009 ).…”

Plasma Metabolome Profiling for the Diagnosis of Catecholamine Producing Tumors

“…Erlic et al compared the same metabolite spectrum in PPGL patients before and post-surgery and found lower histidine levels in preoperative samples (15). A low histidine level is linked to type 2 diabetes, increased inflammation and cardiovascular disease (31)(32)(33), potentially explaining (at least in part) such effects in PPGL patients (31)(32)(33)(34). The negative correlation of histidine with plasma NMN and MTY, urine free EPI and DA in our cohort suggests a catabolic phenotype which has been linked to proinflammatory mediators as well (35).…”

“…compared the same metabolite spectrum in PPGL patients before and post-surgery and found lower histidine levels in preoperative samples ( 15 ). A low histidine level is linked to type 2 diabetes, increased inflammation and cardiovascular disease ( 31 – 33 ), potentially explaining (at least in part) such effects in PPGL patients ( 31 – 34 ).…”