Phenotypic features of central sensitization

Williams, David A.

doi:10.1111/jabr.12135

Cited by 88 publications

(70 citation statements)

References 110 publications

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“…Besides, it is necessary to have evidence of widespread pain and not just localized complaints, hypersensitivity to sensory processes in general, for example, sensitivity to light, sound, touch, odors etc., and symptoms that are a product and contributor to the construct "mental load" such as sleep problems, pain intensity, affective lability, cognitive difficulties and lack of energy and/or fatigue 40 . A set of symptoms commonly identified in patients with CP is the overlap of symptoms, including sleep disturbance, widespread pain, affective disturbance, cognitive disturbance and energy deficit 40,41 . The central sensitization inventory (CSI-BP) is a self-perception scale designed to alert health professionals that the symptoms presented by a patient may be related to some level of CS.…”

Section: Discussionmentioning

confidence: 99%

Central sensitization and beliefs among patients with chronic pain in a primary health care unit

Dionísio¹,

Salermo²,

Padilha³

2020

Brazilian Journal of Pain

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BACKGROUND AND OBJECTIVES: The pain that persists for more than three months is classified as chronic pain. Current studies suggest the existence of a dynamic relationship between biological changes, psychological state, and social context within the pain phenomenon and its chronicity. Central sensitization can be defined as the amplification of the neural signaling within the central nervous system that causes pain hypersensitivity, characterized by overlapping symptoms. The objective of this study was to evaluate the central sensitization, dysfunctional beliefs and other variables such as self-perception about sleep quality in a group of patients with chronic pain. METHODS: The patients answered sociodemographic questions, questions about pain-related habits and beliefs, and completed the central sensitization questionnaire. RESULTS: The 30 participants involved in the study had a mean value of 49.86±16.14 for central sensitization, as well as a high presence of dysfunctional beliefs and poor sleep self-perception. CONCLUSION: The need for a biopsychosocial look aiming to investigate the beliefs and level of central sensitization of patients with chronic pain is becoming increasingly necessary, as it is essential to understand the socioeconomic conditions of each individual for better evaluation and management. An initial educational approach in an easy language that stimulated the reflection and participation of patients to understand their symptoms was well accepted by these patients.

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Section: Discussionmentioning

confidence: 99%

Central sensitization and beliefs among patients with chronic pain in a primary health care unit

Dionísio¹,

Salermo²,

Padilha³

2020

Brazilian Journal of Pain

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“…Quantitative sensory testing (QST) involves protocolized procedures that assess perceptual responses to systematically applied and quantifiable sensory stimuli, in order to evaluate somatosensory function or dysfunction (Cruz‐Almeida & Fillingim, ). QST can identify CS‐related symptomology, including increased sensitivity to nonpainful stimuli (e.g., allodynia), enhanced pain response to painful stimuli (e.g., hyperalgesia), facilitation of centrally‐mediated pain (e.g., temporal summation), and centrally‐mediated pathology in pain inhibitory mechanisms (e.g., conditioned pain modulation; Williams, this Issue). Objective biological markers of CS can also be measured.…”

Section: Assessment Methods For Central Sensitizationmentioning

confidence: 99%

“…At last, David Williams (this Issue) reviews the growing literature on diagnostic phenotyping of CS, including the use of endophenotypes, biomarkers, quantitative sensory testing, and symptom clusters (e.g., sleep difficulties, pain, affect, cognitive difficulties, and low energy [S.P.A.C.E.]) to evaluate CS‐related symptomology.…”

Section: Other Articles In This Special Issuementioning

confidence: 99%

Central Sensitization: A Brief Overview

Gatchel

Neblett

2018

J Appl Biobehavioral Res

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This article introduces a SPECIAL ISSUE of the Journal of Applied Biobehavioral Research on Central Sensitization (CS). First, a general overview of CS is provided, including some historical perspective, the prevalence of CS in various chronic pain disorders, and common ways of measuring CS and related symptoms. Then a brief summary of each contributing article to this SPECIAL ISSUE is provided. Article topics include: CS-related neurobiology; diagnostic phenotyping; a biopsychosocial perspective of CS-related disorders; use of the Central Sensitization Inventory (CSI); evaluation of CS and related symptoms in some specific disorders (including general chronic pain, fibromyalgia, and breast cancer survivors); and how the concept of CS has changed our current view of chronic pain.

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“…There is a general consensus that dynamic QST provides indirect indicators of central pain processing, 6,7,54,55 while static QST, such as pain thresholds, may involve a mix of peripheral and central components. Dynamic and static QST have been widely applied to measure pain sensitivity in clinical pain populations and to further infer the underlying mechanisms.…”

Section: Dynamic Versus Static Qstmentioning

confidence: 99%

<p>Multisensory Sensitivity is Related to Deep-Tissue but Not Cutaneous Pain Sensitivity in Healthy Individuals</p>

Wang¹,

Merkle²,

Lee³

et al. 2020

JPR

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Purpose: Some individuals with chronic pain find daily life sensations (eg, noise, light, or touch) aversive. This amplification of multisensory sensations has been associated with centrally mediated plasticity; for example, greater multisensory sensitivity (MSS) occurs in patients with fibromyalgia than rheumatoid arthritis. However, whether MSS preferentially relates to pain measures which reflect central influences (eg, dynamic quantitative sensory testing (QST) or referred pain), or whether the MSS-pain relationship requires priming from chronic pain, is unknown. Thus, this cross-sectional study investigated the relationships between MSS assessed in a pain-free state and evoked pain sensitivity. Methods: Experimental intramuscular infusion pain and multiple static and dynamic QST were assessed in 465 healthy, pain-free adults: pain thresholds using pressure (PPTs) and heat (HPTs), temporal summation of pain (TSP) using pressure, heat or punctate stimuli, and conditioned pain modulation (CPM) using pressure or heat test stimuli. MSS was assessed using 7 items from Barsky's Somatosensory Amplification Scale. Differences in pain and QST between sex-specific MSS quartiles were assessed, adjusting for multiple comparisons. All participants completed at least one intramuscular infusion condition, but not all were asked to complete each QST (n=166-465). Results: Both static and dynamic QST differed between highest and lowest MSS quartiles using pressure stimuli: lower PPTs (adjusted-p<0.01); increased pressure TSP (adjusted-p=0.02); lower pressure CPM (adjusted-p=0.01). However, none of the heat or punctate QST measures (HPTs, TSP, or CPM) differed between MSS quartiles (adjusted-p>0.05). Odds of experiencing TSP or referred pain was not greater, whereas CPM was 8-fold less likely, in those with highest MSS. Conclusion: Normal variation in non-noxious MSS is related to both static and dynamic pain sensitivity, without sensitization associated with chronic pain, but is dependent on the QST stimulus. Thus, common influences on MSS and pain sensitivity may involve central mechanisms but are likely more complex than previously recognized.

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Phenotypic features of central sensitization

Cited by 88 publications

References 110 publications

Central sensitization and beliefs among patients with chronic pain in a primary health care unit

Central sensitization and beliefs among patients with chronic pain in a primary health care unit

Central Sensitization: A Brief Overview

<p>Multisensory Sensitivity is Related to Deep-Tissue but Not Cutaneous Pain Sensitivity in Healthy Individuals</p>

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