Phenotype-based screening of selected mangrove methanolic crude extracts with anti-melanogenic activity using zebrafish (Danio rerio) as a model

Grisola, Mark Andre C.; Fuentes, Rolly G.

doi:10.2306/scienceasia1513-1874.2017.43.163

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…For instance, Salix alba extract at concentration of 400 ug/mL reduced melanin content in zebrafish embryos to about 40% (relative to untreated control) [85]. This is due to the presence of high phenolic content and depigmenting compounds, majorly lupeol, 3,3′-di-O-methyl ellagic acid and hydrolysable tannins [85]. These depigmenting compounds were known to inhibit TYR activity in vitro [85].…”

Section: Application Of Zebrafish Modelmentioning

confidence: 99%

“…This is due to the presence of high phenolic content and depigmenting compounds, majorly lupeol, 3,3′-di-O-methyl ellagic acid and hydrolysable tannins [85]. These depigmenting compounds were known to inhibit TYR activity in vitro [85]. Other crude extracts such as Anoectochilus extract inhibited the production of melanin in zebrafish embryos [56,86].…”

Section: Application Of Zebrafish Modelmentioning

confidence: 99%

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A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine

Lajis

2018

Medicina

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For years, clinical studies involving human volunteers and several known pre-clinical in vivo models (i.e., mice, guinea pigs) have demonstrated their reliability in evaluating the effectiveness of a number of depigmenting agents. Although these models have great advantages, they also suffer from several drawbacks, especially involving ethical issues regarding experimentation. At present, a new depigmenting model using zebrafish has been proposed and demonstrated. The application of this model for screening and studying the depigmenting activity of many bioactive compounds has been given great attention in genetics, medicinal chemistry and even the cosmetic industry. Depigmenting studies using this model have been recognized as noteworthy approaches to investigating the antimelanogenic activity of bioactive compounds in vivo. This article details the current knowledge of zebrafish pigmentation and its reliability as a model for the screening and development of depigmenting agents. Several methods to quantify the antimelanogenic activity of bioactive compounds in this model, such as phenotype-based screening, melanin content, tyrosinase inhibitory activity, other related proteins and transcription genes, are reviewed. Depigmenting activity of several bioactive compounds which have been reported towards this model are compared in terms of their molecular structure and possible mode of actions. This includes patented materials with regard to the application of zebrafish as a depigmenting model, in order to give an insight of its intellectual value. At the end of this article, some limitations are highlighted and several recommendations are suggested for improvement of future studies.

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Section: Application Of Zebrafish Modelmentioning

confidence: 99%

Section: Application Of Zebrafish Modelmentioning

confidence: 99%

A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine

Lajis

2018

Medicina

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Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders

Merecz-Sadowska

Sitarek

Stelmach

et al. 2022

IJMS

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The kingdom of plants as a “green biofabric” of valuable bioactive molecules has long been used in many ailments. Currently, extracts and pure compounds of plant origin are used to aid in pigmentation skin problems by influencing the process of melanogenesis. Melanin is a very important pigment that protects human skin against ultraviolet radiation and oxidative stress. It is produced by a complex process called melanogenesis. However, disturbances in the melanogenesis mechanism may increase or decrease the level of melanin and generate essential skin problems, such as hyperpigmentation and hypopigmentation. Accordingly, inhibitors or activators of pigment formation are desirable for medical and cosmetic industry. Such properties may be exhibited by molecules of plant origin. Therefore, that literature review presents reports on plant extracts, pure compounds and compositions that may modulate melanin production in living organisms. The potential of plants in the therapy of pigmentation disorders has been highlighted.

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Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants

Chahardehi

Arsad

Lim

2020

Plants

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The zebrafish (Danio rerio) is used as an embryonic and larval model to perform in vitro experiments and developmental toxicity studies. Zebrafish may be used to determine the toxicity of samples in early screening assays, often in a high-throughput manner. The zebrafish embryotoxicity model is at the leading edge of toxicology research due to the short time required for analyses, transparency of embryos, short life cycle, high fertility, and genetic data similarity. Zebrafish toxicity studies range from assessing the toxicity of bioactive compounds or crude extracts from plants to determining the optimal process. Most of the studied extracts were polar, such as ethanol, methanol, and aqueous solutions, which were used to detect the toxicity and bioactivity. This review examines the latest research using zebrafish as a study model and highlights its power as a tool for detecting toxicity of medicinal plants and its effectiveness at enhancing the understanding of new drug generation. The goal of this review was to develop a link to ethnopharmacological zebrafish studies that can be used by other researchers to conduct future research.

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Phenotype-based screening of selected mangrove methanolic crude extracts with anti-melanogenic activity using zebrafish (Danio rerio) as a model

Cited by 3 publications

References 17 publications

A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine

A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine

Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders

Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants

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