Phenothiazines and Chromosome Damage

Jenkins, Edmund C.

doi:10.1508/cytologia.35.552

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Neuroleptic Drugs1

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1973

2004

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Cited by 19 publications

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References 21 publications

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“…Although in at least one of the early reports, there was a significantly higher frequency of chromosomal breaks in the phenothiazine-treated group than in the control group, in a more recent well-designed prospective study no increase in chromosome breaks in phenothiazine (chlorpromazine and/or per phenazine) treated patients were found {Cohen, Hirsekorn and Frosch, 1967;Nielsen, Friedrich and Tsuboi, 1969;Jenkins, 1970;Gilmour et ai, 1971;Cohen, Leiber and Schwartz, 1972).…”

Section: Neuroleptic Drugsmentioning

confidence: 94%

Adverse Effects in Maintenance Therapy

Ban¹

1978

Int Pharmacopsychiatry

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Section: Neuroleptic Drugsmentioning

confidence: 94%

Adverse Effects in Maintenance Therapy

Ban¹

1978

Int Pharmacopsychiatry

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Trifluperazine Dihydrochloride 440‐17‐5

2004

Sax's Dangerous Properties of Industrial Materials

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Possible mutagenicity of the psychoactive phenothiazine derivative perazine in vivo and in vitro

et al. 1980

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Human lymphocyte cultures from 55 schizophrenic subjects and one manic-depressive subject being treated with the phenothiazine derivative perazine and with other drugs were analyzed with respect to chromosomal damage. The frequency of exchange-type aberrations in these subjects was more than double that in clinically normal control subjects. No correlation was detectable between the aberration frequency and sex, age, smoking and drinking habits, and treatment conditions. It is possible that the elevation of the chromosomal aberration frequency is due to perazine. In vitro studies with perazine and two main metabolites (desmethylperazine and perazine sulfoxide) with human lymphocytes and CHO cells with and without metabolic activation by liver microsomes gave negative results with respect to the induction of sister chromatid exchanges. Possible differences in the metabolism of perazine in vivo and in vitro are discussed.

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Phenothiazines and Chromosome Damage

Cited by 19 publications

References 21 publications

Adverse Effects in Maintenance Therapy

Adverse Effects in Maintenance Therapy

Trifluperazine Dihydrochloride 440‐17‐5

Possible mutagenicity of the psychoactive phenothiazine derivative perazine in vivo and in vitro

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