Phenolic profile and biological activity of Hypericum perforatum L.: Can roots be considered as a new source of natural compounds?

Tusevski, Oliver; Krstikj, Marija; Станоева, Јасмина Петреска; Стефова, Марина; Simic, Sonja Gadzovska

doi:10.1016/j.sajb.2018.05.030

Cited by 50 publications

(29 citation statements)

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“…Abdel‐Raziq et al () also reported the isolation of flavonoids from the ethyl acetate fraction of Musa cavendishii leaf, having α‐amylase inhibitory activity. Plants containing kaempferol and quercetin have already been reported to have antidiabetic properties (Tusevski, Krstikj, Stanoeva, Stefova, & Simic, ). Kappel et al () concluded that rutin is a major compound with antidiabetic property in the leaf of Musa paradisiaca L. Kaempferol and its glucoside have been reported to have many biological activities and they are found in many plant families including Musaceae (Calderon‐Montano, Burgos‐Morón, Pérez‐Guerrero, & López‐Lázaro, ).…”

Section: Discussionmentioning

confidence: 99%

“…TA B L E 5 1 H, 13 C NMR, and distortion-less enhancement by polarization of rutin Plants containing kaempferol and quercetin have already been reported to have antidiabetic properties (Tusevski, Krstikj, Stanoeva, Stefova, & Simic, 2018). Kappel et al (2013) concluded that rutin is a major compound with antidiabetic property in the leaf of Musa paradisiaca L. Kaempferol and its glucoside have been reported to have many biological activities and they are found in many plant…”

Section: Discussion and Con Clus I On Smentioning

confidence: 99%

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Isolation of flavonoids from Musa acuminata Colla (Simili radjah, ABB) and the in vitro inhibitory effects of its leaf and fruit fractions on free radicals, acetylcholinesterase, 15‐lipoxygenase, and carbohydrate hydrolyzing enzymes

et al. 2020

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Musa species are used traditionally for the management of many diseases. The study evaluated and compared anticholinesterase, anti‐inflammatory, antioxidant, and antidiabetic activities of Musa acuminata (Simili radjah, ABB) fruits and leaves fractions and characterized the bioactive compounds using HPTLC‐HRMS and NMR. Leaf fractions gave the higher biological activities than the fruit. Ethyl acetate fraction of the leaf had the highest total phenolic content (911.9 ± 1.7 mg GAE/g) and highest 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH·) scavenging activity (IC50, 9.0 ± 0.4 µg/ml). It also gave the most effective inhibition of acetylcholinesterase (IC50, 404.4 ± 8.0 µg/ml) and α‐glucosidase (IC50, 4.9 ± 1.6 µg/ml), but a moderate α‐amylase inhibition (IC50, 444.3 ± 4.0 µg/ml). The anti‐inflammatory activity of n‐butanol (IC50, 34.1 ± 2.6 µg/ml) and ethyl acetate fractions (IC50, 43.1 ± 11.3 µg/ml) of the leaf were higher than the positive control, quercetin (IC50, 54.8 ± 17.1 µg/ml). Kaempferol‐3‐O‐rutinoside and quercetin‐3‐O‐rutinoside (rutin) were identified as the bioactive compounds with antioxidant and antidiabetic activities from the ethyl acetate fraction of M. acuminata leaf. Practical applications All parts of Musa acuminata are known to be useful ethnomedicinally even as food. The leaves are mostly used to serve food and used for wrapping purposes. However, this study concluded that M. acuminata leaf is rich in bioactive flavonoids such as kaempferol‐3‐O‐rutinoside and rutin, with relatively high antioxidative, antidiabetic, and anti‐inflammatory activities. Therefore, aside the fact that the leaves can serve as potential drug leads for pharmaceutical industries, it can also be embraced in the food sector to produce supplements and/or nutraceuticals in the management of Alzheimer's, diabetes and other inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussion and Con Clus I On Smentioning

confidence: 99%

Isolation of flavonoids from Musa acuminata Colla (Simili radjah, ABB) and the in vitro inhibitory effects of its leaf and fruit fractions on free radicals, acetylcholinesterase, 15‐lipoxygenase, and carbohydrate hydrolyzing enzymes

et al. 2020

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“…Even so, the biological properties of H. perforatum have been attributed to numerous bioactive compounds belonging to the classes of flavonoids and phenolic acids. These bioactive metabolites usually accumulate in leaves and flowers [11]. All of these species have received increasing interest in recent years due to the growing market demand for natural bioactive compounds that avoid the side effects that are typical of synthetic drugs.…”

Section: Introductionmentioning

confidence: 99%

Enzyme and Biological Activities of the Water Extracts from the Plants Aesculus hippocastanum, Olea europaea and Hypericum perforatum That Are Used as Folk Remedies in Turkey

et al. 2020

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Phenolic compounds are secondary metabolites that are found ubiquitously in plants, fruits, and vegetables. Many studies have shown that regular consumption of these compounds could have a positive effect on our health. The aim of this study was to compare the phytochemical contents of the water extracts from three different plants used as folk remedies in Turkey: Aesculus hippocastanum, Olea europaea, and Hypericum perforatum. A liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS) analysis was performed to explore the phenolic profiles. The biological activities of these extracts were also evaluated in terms of their antioxidant activities (2,2-diphenyl-1-picrylhydrazyl DPPH, 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid ABTS, Ferric Reducing Antioxidant Power Assay FRAP, cupric ion reducing antioxidant capacity CUPRAC, β-carotene, phosphomolybdenum, and metal chelating) and enzyme inhibitory properties (against acetylcholinesterase, butyrylcholinesterase, and tyrosinase). The aqueous extract of H. perforatum showed the highest levels of total phenolic, flavonoid, and saponin contents. Protocatechuic acid, vanillic acid, verbascoside, hesperidin, hyperoside, apigenin 7-hexosides, and quercetin were the most common compounds found in this species. The results confirm that A. hippocastanum, O. europaea, and H. perforatum represent a potential source of natural-derived molecules with positive properties that could be used as valid starting point for new food supplements, and drugs in the pharmaceutical, cosmetic, and food industries.

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“…Bacillus subtilis, Escherichia coli ve Pseudomonas aeruginosa suşları üstünde H. perforatum kök ekstraktlarının antibakteriyel etkiye sahip olduğu gözlenmiştir. Bu etkinin ekstrakt bileşeninde bulunan garsinon C ve γ-mangostin maddelerinden kaynaklı olduğu düşünülmüş, ayrıca test edilen bazı maya ve küf türlerine karşı da kök ekstraktlarının antifungal etkiye sahip olduğu tespit edilmiştir [31].…”

Section: Bakteriunclassified

Antibacterial Effect of Hypericum atomarium Boiss. Extracts against Clinical Staphylococcus spp.

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Çevikbaş

2018

Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi

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Özet: Hypericum atomarium Boiss, Hypericum cinsine ait çok yıllık bir bitki olup, geleneksel tedavi yöntemlerinde tedavi amacıyla kullanılmaktadır. Yapılan bu çalışma ile H. atomarium Boiss. çiçeklerinden hazırlanan metanol (MeOH), kloroform (CHCl3) ve su (H2O) eksraktlarının klinik Stafilokok izolatları (S. aureus, S. hominis, S. haemolyticus, S. epidermidis) üzerine antibakteriyel etkisi araştırılmıştır. Elde edilen sonuçlara göre hazırlanan tüm ekstraktların klinik izolatlar üzerinde yüksek oranlarda antibakteriyel etkiye sahip oldukları tespit edilmiştir. En fazla antibakteriyel etki kloroform ile hazırlanan ekstrakta (20,7 mm) tespit edilmiş olup tüm izolatlar değerlendirildiğinde inhibisyon değerlerinin 20,7-16 mm arasında olduğu tespit edilmiştir.

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Phenolic profile and biological activity of Hypericum perforatum L.: Can roots be considered as a new source of natural compounds?

Cited by 50 publications

References 47 publications

Isolation of flavonoids from Musa acuminata Colla (Simili radjah, ABB) and the in vitro inhibitory effects of its leaf and fruit fractions on free radicals, acetylcholinesterase, 15‐lipoxygenase, and carbohydrate hydrolyzing enzymes

Isolation of flavonoids from Musa acuminata Colla (Simili radjah, ABB) and the in vitro inhibitory effects of its leaf and fruit fractions on free radicals, acetylcholinesterase, 15‐lipoxygenase, and carbohydrate hydrolyzing enzymes

Enzyme and Biological Activities of the Water Extracts from the Plants Aesculus hippocastanum, Olea europaea and Hypericum perforatum That Are Used as Folk Remedies in Turkey

Antibacterial Effect of Hypericum atomarium Boiss. Extracts against Clinical Staphylococcus spp.

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