Phenolic compounds: Natural alternative in inflammation treatment. A Review

Ambriz-Pérez, Dulce Libna; Leyva‐López, Nayely; Gutiérrez‐Grijalva, Erick P.; Heredia, J. Basilio

doi:10.1080/23311932.2015.1131412

Cited by 199 publications

(198 citation statements)

References 69 publications

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“…These phenolic compounds are ubiquitous and rich in medicinal herbs and dietary plants. Several phenolic compounds contribute toward inhibiting carcinogenesis mechanism and show chemopreventive activities by their diverse range of biological activities [62] (Table 4).…”

Section: Herbal Products Used For Prevention Of Breast Cancermentioning

confidence: 99%

Herbal Remedies for Breast Cancer Prevention and Treatment

Laskar¹,

Lourembam²,

Mazumder³

2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

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Breast cancer is among the most common type of cancer in women around the globe. Prevention of breast cancer is better than its treatment. Because of the molecular variation and complexity underlying breast cancer occurrence, its treatment by using chemotherapy and/or radiotherapy is very complicated and often leads to undesirable side effects. Plants and their extracts have been used for centuries for the treatment of almost every disease and breast cancer is not an exception. Herbal products can be trusted for cancer treatment because of their low toxicity. Besides, herbal remedies are easily accepted by the majority of woman suffering from breast cancer because of their easy availability and affordability. In the last decade, a large number of plants and their compounds were reported to show promising anticancerous effects against breast cancer cells in both in vivo and in vitro models. However, their beneficial effects on breast cancer treatment are still doubtful due to the lack of randomized clinical trials. This chapter is dedicated to reporting the potential of some herbal products for the prevention and/or treatment of breast cancer. Besides, it focused on the anticarcinogenic mechanism of those phytocompounds to report their potential chemotherapeutic role.

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Section: Herbal Products Used For Prevention Of Breast Cancermentioning

confidence: 99%

Herbal Remedies for Breast Cancer Prevention and Treatment

Laskar¹,

Lourembam²,

Mazumder³

2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

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“…Naturally occurring phenolic compounds 8 to 32 (Figure ) elicit anti‐inflammatory action by inhibiting NO . Four farnesyl phenols (grifolinones A and B, grifolin, and neogrifolin; 8‐11 ) extracted from an inedible mushroom, Albatrellus caeruleoporus , exhibit inhibitory activity (IC 50 23.4, 22.9, 29.0, and 23.3 µM, respectively) significantly higher than synthetic iNOS inhibitor, l ‐NMA (IC 50 88.4 µM) ( 1 , Figure ) against LPS‐stimulated NO production in RAW‐264.7 cells.…”

Section: Natural Inos Inhibitorsmentioning

confidence: 99%

Inducible nitric oxide synthase inhibitors: A comprehensive update

Minhas

Bansal

2019

Medicinal Research Reviews

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Inducible nitric oxide synthase (iNOS), which is expressed in response to bacterial/proinflammatory stimuli, generates nitric oxide (NO) that provides cytoprotection. Overexpression of iNOS increases the levels of NO, and this increased NO level is implicated in pathophysiology of complex multifactorial diseases like Parkinson's disease, Alzheimer's disease, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Selective inhibition of iNOS is an effective approach in treatment of such complex diseases. L-Arginine, being a substrate for iNOS, is the natural lead to develop iNOS inhibitors. More than 200 research reports on development of nitric oxide synthase inhibitors by different research groups across the globe have appeared in literature so far. The first review on iNOS, in 2002, discussed the iNOS inhibitors under two classes that is, amino acid and non-amino acid derivatives. Other review articles discussing specific chemical classes of iNOS inhibitors also appeared during last decade. In the present review, all reports on both natural and synthetic iNOS inhibitors, published 2002 onwards, are studied, classified, and discussed to provide comprehensive information on iNOS inhibitors. The synthetic inhibitors are broadly classified into two categories that is, arginine and non-arginine analogs. The latter are further classified into amidines, five-or six-membered heterocyclics, fused cyclics, steroidal type, and chalcones analogs. Structures of the most/significantly potent compounds from each report are provided to know the functional groups important for incurring iNOS inhibitory activity and selectivity. This review is aimed to provide a comprehensive view to the medicinal chemists for rational designing of novel and potent iNOS inhibitors. K E Y W O R D S arginine, inflammation, inhibitors, multifactorial disease, nitric oxide 1 | INTRODUCTION Nitric oxide (NO) is a relaxing factor derived from endothelium, which is responsible for neuronal transmission, cardiovascular, gastrointestinal, genitourinary, respiratory, antipathogenic, and antitumor responses. The production of NO is effected by nitric oxide synthase (NOS) through catalysis of NADPH-dependent oxidation of L-arginine (the substrate). 1NOS exists in three distinct isoforms, depending on the site of its existence that is, neuronal NOS (nNOS, type I), inducible or inflammatory NOS (iNOS, type II) and endothelial NOS (eNOS, type III). Constitutive NOS are regulated by the binding of calcium-calmodulin protein, whereas iNOS is transcriptionally regulated and calcium-calmodulin independent. NO plays both physiological and pathological roles depending on the magnitude and duration of its production. 2 The physiological roles of NO are executed by soluble guanylate cyclase. Indeed, NO activates it, with the consequent increase of cyclic guanosine-3′,5′-monophosphate (cGMP) level, which subsequently activates intracellular effector molecules, cGMPdependent protein kinases, cGMP-gated ion channels, and cGMP-regulated phosphodiesteras...

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“…22 Phenolic acids are subclassified as benzoic acid and cinnamic acid backbone structure containing seven (C6-C1) and nine (C6-C3) carbon atoms respectively. Hydroxybenzoic acid derivatives such as gallic acid (GA), protocatechuic acid (PCA), gentisic acid (GNA), vanillic acid (VA), p-hydroxy benzoic acid (BA), syringic acid (SGA), ellagic acid (EA) and cinnamic acid derivatives such as caffeic acid (CA), chlorogenic acid (CGA), ferulic acid (FA), sinapic acid (SA), p-coumaric acid (p-CA) are predominantly available in plants.…”

Section: Phenolic Acid Analysis By Hplcmentioning

confidence: 99%

HPLC Analysis of Phenolic Acids and Antioxidant Activity of Some Classical Ayurvedic Guggulu Formulations

Hazra¹,

Sur²,

Chakraborty³

et al. 2018

Int. J. Res. Ayurveda Pharm.

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Classical guggulu formulations have been used as mainstay therapeutics in chronic inflammatory diseases in Ayurvedic system of medicine since centuries. The present study included six guggulu formulations such as Kaishora guggulu, Kanchanara guggulu, Yogaraj guggulu, Punrnava guggulu, Amritadi guggulu and Trayodasanga guggulu.Phenolic compounds play a vital role as evident from phenolic and flavonoid content in guggulu drugs as well as antioxidant activity assayed by DPPH radical scavenging activity and FRAP antioxidant power. Yograj guggulu was found to have strong reducing ability (1156.76 µM Fe(II)/mg) among six drugs chosen in this investigation and Amritadi guggulu has revealed powerful scavenger of DPPH radicals (IC50:1.05 mg/ml). Phenolic acid composition for each guggulu drug was analyzed and twelve phenolic acid compounds were identified and estimated by HPLC. Gallic acid (8.29-49.28 mg/g) was found in high concentration and ellagic acid (0.69-6.02 mg/g) was found to the next in all formulations. Other phenolic acid components estimated were protocatechuic acid, p-hydroxybenzoic acid, gentisic acid, chlorogenic acid, vanillic acid, caffeic acid, syringic acid, p-coumaric acid, ferulic acid, sinapic acid in all guggulu formulations. A synergistic activity towards therapeutic efficacy was proposed on the basis of phenolic acid composition in each guggulu formulation.

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Phenolic compounds: Natural alternative in inflammation treatment. A Review

Cited by 199 publications

References 69 publications

Herbal Remedies for Breast Cancer Prevention and Treatment

Herbal Remedies for Breast Cancer Prevention and Treatment

Inducible nitric oxide synthase inhibitors: A comprehensive update

HPLC Analysis of Phenolic Acids and Antioxidant Activity of Some Classical Ayurvedic Guggulu Formulations

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