Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida

Abstract

Coriolopsis rigida was isolated as an endophytic fungus from the medicinal plant Cochlospermum regium, and their production of secondary metabolites has not yet been investigated. Thus, the endophyte was cultivated on rice solid media to evaluate its ability to produce bioactive compounds and then the chloroform extract was obtained. Two phenolic compounds, tyrosol (1) and a new natural product p-hydroxyphenylacetamide (2), were isolated from the extract. The structures of the compounds were elucidated mainly by NMR. The extract showed potent antioxidant activity with an efficient concentration (EC50) value of 0.33 mg mL -1 . Additionally, demonstrated allelopathic activity inhibited the seedling growth of Lactuca sativa L. and Raphanus sativus L. by 63% and 55%, respectively.

Isolation and Identification of Pigment-Producing Endophytic Fungi from the Amazonian Species Fridericia chica

“…Phenolic compounds are a class of molecules that have a wide distribution in natural products and have attracted a lot of attention due to their antioxidant and antimicrobial properties [63]. Antioxidant compounds produced by endophytic fungi are usually from the class of phenolic compounds, such as flavonoids and phenolic acids, which corroborates the results found in this study [64][65][66]. Additionally, the infrared spectrum obtained for the active pigmented extract is in accordance with the results of the TLC.…”

Neuroprotective effect of endophytic fungal antioxidant polyphenols on cerebral ischemic stroke-induced Albino rats; memory impairments, brain damage, and upregulation of metabolic proteins

“…In recent years, an increasing interest has been shown in endophytes extract because of its safety and anti-stroke properties. The ability of phenolic compounds to cross blood-brain barrier and neuroprotective property without any side effect was reported previously (Dantas et al, 2022). In this study, we analyzed the impact of phenolic compounds in a rat model of cerebral ischemia injury and we observed that pretreatment of Albino rat with phenolic compound at 10-200 mg/kg/day improved protection against oxidative stress.…”

Biochemical Analysis and Characterization of Silver Nanoparticles Synthesized by the Endophytic Fungus Plectosphaerella oligotrophica S8A26 Associated with Anaphalis contorta

“…They also possess anti-ageing properties, for which they are used in the cosmetic industry [30]. In a recent study, [31] isolated two phenolic compounds, tyrosol and phydroxyphenylacetamide, from the endophytic fungus Coriolopsis rigida obtained from the medicinal plant Cochlospermum regium that showed potent antioxidant activity with an EC50 of 0.33 mg/mL and effective allelopathic activity against the seedlings of Lactuca sativa and Raphanus sativus. Compounds belonging to saponins have been known to show antibacterial, antifungal, antiviral, anti-inflammatory, anticancer, antioxidant, and immunomodulatory effects [32].…”