Phenolic and flavonoid compounds of Ziziphora clinopodioides

Oganesvan, G. B.; Galstyan, Anahit; Mnatsakanyan, V. A.; Paronikyan, R. V.; Ter-Zakharyan, Yu. Z.

doi:10.1007/bf00629776

Cited by 61 publications

(66 citation statements)

References 3 publications

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“…Lipophilic flavonoids isolated from Ziziphora species like chrysin (2), acacetin (5) or thymonin (4) have antimicrobial effects and are components of, for example, propolis, a well-known antimicrobial active material [50,61]. Antibacterial flavonoids probably possess multiple cellular targets rather than one specific site of action.…”

Section: Omementioning

confidence: 99%

“…Carvacrol (72) and thymol (61) are often mentioned as inhibitors of growth of food-borne pathogens. These pathogens are represented for example by different strains of Salmonella, Shigella, E. coli or Clostridium.…”

Section: O Hmentioning

confidence: 99%

“…From flavonoids, only a limited number of glycosides (diosmin (7) and linarin (8)) was isolated. [39,61] Low vasorelaxant activity (IC50 not calc.) [39] Toxicity against Artemia salina larvae [62] Antiradical [63] Weak antibacterial effect [ [39,61] Low vasorelaxant activity (IC50 not calc.)…”

Section: Phenolicsmentioning

confidence: 99%

“…[39,61] Low vasorelaxant activity (IC50 not calc.) [39] Toxicity against Artemia salina larvae [62] Antiradical [63] Weak antibacterial effect [ [39,61] Low vasorelaxant activity (IC50 not calc.) [39] Toxicity against Artemia salina larvae [62] Antiradical [63] Weak antibacterial effect [61] OH OCH3 OCH3 OCH3 OH H Acacetin (5) Z. clinopodioides [39] Low vasorelaxant activity (IC50 not calc.)…”

Section: Phenolicsmentioning

confidence: 99%

“…[39] Toxicity against Artemia salina larvae [62] Antiradical [63] Weak antibacterial effect [ [39,61] Low vasorelaxant activity (IC50 not calc.) [39] Toxicity against Artemia salina larvae [62] Antiradical [63] Weak antibacterial effect [61] OH OCH3 OCH3 OCH3 OH H Acacetin (5) Z. clinopodioides [39] Low vasorelaxant activity (IC50 not calc.) [39] Inhibition of angiogenesis [64,65] Induction of apoptosis in different cancer cell lines [66][67][68][69][70] Inhibition of TNF-related apoptosis [71] Anticancer [72,73] Induction of melanogenesis in B16F10 cells [74] Cytotoxic against HL-60 cells cells [75] Interaction with telomeres [76] Antimetastatic effect [77,78] Diosmetin (6) Z. clinopodioides [4] Some inhibitory activity on NO production stimulated by LPS and IFN-γ in RAW 264.7 cells [4] Cytotoxic against HL-60 cells cells [75] Induction of melanogenesis in B16F10 cells [73,74] Review on bioactivity [79] H OH H OH OCH 3 H Diosmin (7) Z. clinopodioides [80] Antidiabetic activity (reviewed by Abdurrazak et al [81]) Review on clinical use [82] H O-Glc-Rha H OH OCH 3 Hf Linarin (8) Z. clinopodioides [44,80] Inhibition of mucin production and secretion in airways epithelial cells …”

Section: Phenolicsmentioning

confidence: 99%

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Kazakh Ziziphora Species as Sources of Bioactive Substances

et al. 2016

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Ziziphora species represent the prototypical example of the Lamiaceae family. The phytochemicals present in Ziziphora include monoterpenic essential oils, triterpenes and phenolic substances belonging to the flavonoids. In Kazakh traditional medicine, Ziziphora species possess several medicinal uses. In particular, Z. bungeana Lam. and Z. clinopodioides Lam. are used for the treatment of illnesses related to the cardiovascular system or to combat different infections. Unfortunately, the majority of the information about the complex Ziziphora species is only available in Russian and Chinese language, therefore, we decided gather all available information on Kazakhstan Ziziphora, namely its content compounds, medicinal uses and published patents, to draw the attention of scientists to this very interesting plant with high medicinal potential.

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Section: Omementioning

confidence: 99%

Section: O Hmentioning

confidence: 99%

Section: Phenolicsmentioning

confidence: 99%

Section: Phenolicsmentioning

confidence: 99%

Section: Phenolicsmentioning

confidence: 99%

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Kazakh Ziziphora Species as Sources of Bioactive Substances

et al. 2016

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Ziziphora clinopodioides Lam leaves aqueous extract mediated synthesis of zinc nanoparticles and their antibacterial, antifungal, cytotoxicity, antioxidant, and cutaneous wound healing properties under in vitro and in vivo conditions

Mahdavi

Saneei

Qorbani

et al. 2019

Applied Organom Chemis

142

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LamZiziphora clinopodioides Biosynthesis of metal nanoparticles using plant medicine is under exploration is due to wide biomedica applications and research interest in nanotechnology, the recent study was assessing green synthesis of zinc nanoparticle using ), the use of plant material Ziziphoraleaves extract (ZnNPs@ not only makes the process eco-friendly but also the abundance makes it more economical. Also, in this study, Vis. and-were characterized using different techniques including UVZiziphora were synthesized in aqueous medium using the plant extract as stabilizing and reducing agents. The synthesized ZnNPs@Ziziphora conditions. ZnNPs@in vivo and in vitro under Ziziphorawe investigated the therapeutical properties of ZnNPs@ FT-IR spectroscopy, . SEM images exhibited a uniform spherical morphology in size of 32.34 Thermal Gravimetric Analysis (TGA)ray diffraction (XRD), scanning electron microscopy (SEM), and Energy Dispersive X-ray Spectrometry (EDS), and-X Escherichia coli, and Pseudomonas aeruginosa, Salmonella typhimurium part of this study, these nanoparticles indicated excellent antibacterial properties against Gram-negative bacteria (in vitronm for the biosynthesized nanoparticles. In the biological , andCandida krusei, Candida albicans, Candida glabrata), antifungal potentials against Bacillus subtilis, andStaphylococcus aureus, Streptococcus pneumoniaO157:H7) and Grampositive bacteria ( leaves aqueous extract can be used to yield zinc nanoparticles with a significant amount of antibacterial, antifungal, antioxidant, and cutaneous wound healing properties without any cytotoxicity.Z. clinopodioides ointment ameliorated the cutaneous wounds with increasing the levels of wound contracture, vessel, hydroxyl proline, hexosamine, hexuronic acid, fibrocyte, and fibrocytes/fibroblast rate and decreeing the wound area, total cells, and lymphocyte compared to other groups in rats. The results of UV, FT-IR, XRD, FE-SEM, EDS, and TGA confirm that the Ziziphora part of our

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Assessment of antioxidant, cytotoxicity, antibacterial, antifungal, and cutaneous wound healing activities of green synthesized manganese nanoparticles using Ziziphora clinopodioides Lam leaves under in vitro and in vivo condition

Mahdavi

Paydarfard

Zangeneh

et al. 2019

Applied Organom Chemis

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In recent decades, nanotechnology is growing rapidly owing to its widespread application in medical science. The aim of the experiment was the evaluation of cytotoxicity, antioxidant, antibacterial, antifungal, and cutaneous wound healing activities of green synthesized manganese nanoparticles using Ziziphora clinopodioides Lam leaves (MnNPs@ZC). The synthesized MnNPs@ZC were characterized using different techniques including UV–Vis., FT‐IR spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X‐ray spectrometry (EDS). According to the XRD analysis, 48.10 nm was measured for the crystal size of nanoparticles. SEM images exhibited a uniform spherical morphology and size in the range of 47.58 to 70.26 nm for the biosynthesized nanoparticles. MnNPs@ZC revealed excellent non‐cytotoxicity effect against human umbilical vein endothelial cells, antioxidant activity against DPPH, antibacterial properties against Gram‐negative bacteria (Salmonella typhimurium, Pseudomonas aeruginosa, and Escherichia coli O157:H7) and Gram‐positive bacteria (Streptococcus pneumonia, Staphylococcus aureus, and Bacillus subtilis), and antifungal potentials against Candida glabrata, Candida albicans, Candida guilliermondii, and Candida krusei. Also, use of MnNPs@ZC ointment decreased significantly (p ≤ 0.01) the wound area, total cells, neutrophil, and lymphocyte and raised significantly (p ≤ 0.01) the wound contracture, hydroxyl proline, hexosamine, hexuronic acid, fibrocyte, and fibrocytes/fibroblast rate compared to other groups in experimental animals. In conclusion, synthesized MnNPs@ZC indicated antibacterial, antifungal, non‐cytotoxicity, antioxidant, and cutaneous wound healing effects in a dose‐depended manner. After confirming in the clinical trials, these nanoparticles can be used in human for the treatment of cutaneous and infectious diseases.

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Phenolic and flavonoid compounds of Ziziphora clinopodioides

Cited by 61 publications

References 3 publications

Kazakh Ziziphora Species as Sources of Bioactive Substances

Kazakh Ziziphora Species as Sources of Bioactive Substances

Ziziphora clinopodioides Lam leaves aqueous extract mediated synthesis of zinc nanoparticles and their antibacterial, antifungal, cytotoxicity, antioxidant, and cutaneous wound healing properties under in vitro and in vivo conditions

Assessment of antioxidant, cytotoxicity, antibacterial, antifungal, and cutaneous wound healing activities of green synthesized manganese nanoparticles using Ziziphora clinopodioides Lam leaves under in vitro and in vivo condition

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