Kazakh Ziziphora Species as Sources of Bioactive Substances

Šmejkal, Karel; Malaník, Milan; Zhaparkulova, Karlygash; Sakipova, Zuriyadda; Ibragimova, Liliya; Ибадуллаева, Г.С.; Žemlička, Milan

doi:10.3390/molecules21070826

Cited by 27 publications

(22 citation statements)

References 410 publications

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“…Apigenin, chrysin, luteolin, acacetin and diosmetin are among the phenolic compounds that have been detected in Z. clinopodioiedes, which is also the most studied species [16][17][18]. Various studies focused on possible biologic activity related to the chemical profile of the plant.…”

Section: Introductionmentioning

confidence: 99%

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Study on the Chemical Composition, Enzyme Inhibition and Antioxidant Activity of Ziziphora taurica subsp. cleonioides

et al. 2019

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Ziziphora is a plant used in Turkish and Iran traditional medicine for its antibacterial activity, sedative and stomach soothing properties. Although the chemical profile of the essential oil of different Ziziphora species is well documented, data regarding plant extracts are incomplete. In this study extracts from Ziziphora taurica subsp. cleonioides were obtained using ethyl acetate, methanol and water and the chemical profile of the aerial part of the plant was elucidated. Among the compounds identified, rosmarinic acid was the most abundant (3375.67 ± 38.02 μg/mL), at the extract of methanol, followed by chlorogenic acid (3225.10 ± 16.44). Enzyme inhibition activity against α-amylase and tyrosinase was also estimated. The ethyl acetate extract showed the highest α-amylase activity (1.95 ± 0.04 mg/mL), while the best anti-tyrosinase activity was calculated for the methanolic extract (1.25 ± 0.01 mg/mL). In addition, total phenolic, flavonoid content and antioxidant activity were evaluated. According to our results, bioactivity of the plant is of great interest, nonetheless, at the same time, it is strongly depended on the solvent used during the extraction process. Our data suggest that the plant under study may be an important source to consider against metabolic, skin pigmentation and oxidative stress related disorders.

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Section: Introductionmentioning

confidence: 99%

“…Various studies focused on possible biologic activity related to the chemical profile of the plant. These studies include reduction of vascular tension [19], antidiabetic, antihypertensive, antioxidant [20] and anticancer activity [18].…”

Section: Introductionmentioning

confidence: 99%

Study on the Chemical Composition, Enzyme Inhibition and Antioxidant Activity of Ziziphora taurica subsp. cleonioides

et al. 2019

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“…The leaves are short, petiolate, or sub-sessile. The flowering period is from June to September, depending on environmental conditions [4].…”

Section: Introductionmentioning

confidence: 99%

“…Previously conducted studies on the phytochemical profile of species belonging to the genus Ziziphora have been mainly focused on the composition of its essential oils. Apart from essential oils, these species are also a rich source of other secondary metabolites, including flavonoids, derivatives of caffeic acid, fatty acids, triterpenes, and sterols [4,7], more than forty natural compounds have been isolated from different Ziziphora species. Among these secondary metabolites, phenolic compounds are certainly the most important due to their positive impact on health, reducing the risk of cardiovascular disease, neurodegenerative disorders, and cancer [8].…”

Section: Introductionmentioning

confidence: 99%

Ziziphora taurica subsp. taurica: Analytical Characterization and Biological Activities

et al. 2019

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The Lamiaceae family comprises many flowering plants classified into about 236 genera. The genus Ziziphora is one of the well-known genera of this family and its species are important in different fields of pharmaceutical, chemical, traditional, and folk medicines. The phytochemicals present in Ziziphora include monoterpenic essential oils, triterpenes, and phenolic substances. The aim of this paper was to study the phytochemical profile of Ziziphora taurica subsp. taurica and compare and evaluate the biological activities of its ethyl acetate (ZTT-EtOAc), methanolic (ZTT-MeOH), and aqueous (ZTT-W) extracts based on their enzyme inhibition and antioxidant capacities. Determination of total phenolic (TPC) and total flavonoid (TFC) contents as well as biological activities were determined using spectrophotometric procedures. Subsequently, the individual phenolic compounds were detected by liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS/MS). In total, twenty-two different phenolic compounds were identified, including apigenin, ferulic acid, and luteolin which were the most common. ZTT-MeOH extract showed the best antioxidant activity, whereas ZTT-EtOAc extract was the most effective against tyrosinase and α-amylase. Ziziphora taurica subsp. taurica represents a potential source of natural compounds with positive effects on human health.

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“…The Ziziphora species are rich in flavonoids, caffeic acid derivatives, fatty acids, triterpenes, and sterols. The essential oils of Ziziphora have been well studied [ 34 ]. In the flora of Uzbekistan, this genus consists of eight species, including Ziziphora capitata L., Z. clinopodioides Lam., Z. interrupta Juz., Z. pamiroalaica Juz., Z. pedicellata Pazij & Vved., Z. persica Bunge, Z. suffruticosa Pazij & Vved., and Z. tenuior L. [ 2 ].…”

Section: Essential Oils From the Uzbek Lamiaceae Speciesmentioning

confidence: 99%

Aromatic Medicinal Plants of the Lamiaceae Family from Uzbekistan: Ethnopharmacology, Essential Oils Composition, and Biological Activities

et al. 2017

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Plants of the Lamiaceae family are important ornamental, medicinal, and aromatic plants, many of which produce essential oils that are used in traditional and modern medicine, and in the food, cosmetics, and pharmaceutical industry. Various species of the genera Hyssopus, Leonurus, Mentha, Nepeta, Origanum, Perovskia, Phlomis, Salvia, Scutellaria, and Ziziphora are widespread throughout the world, are the most popular plants in Uzbek traditional remedies, and are often used for the treatment of wounds, gastritis, infections, dermatitis, bronchitis, and inflammation. Extensive studies of the chemical components of these plants have led to the identification of many compounds, as well as essentials oils, with medicinal and other commercial values. The purpose of this review is to provide a critical overview of the literature surrounding the traditional uses, ethnopharmacology, biological activities, and essential oils composition of aromatic plants of the family Lamiaceae, from the Uzbek flora.

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Kazakh Ziziphora Species as Sources of Bioactive Substances

Cited by 27 publications

References 410 publications

Study on the Chemical Composition, Enzyme Inhibition and Antioxidant Activity of Ziziphora taurica subsp. cleonioides

Study on the Chemical Composition, Enzyme Inhibition and Antioxidant Activity of Ziziphora taurica subsp. cleonioides

Ziziphora taurica subsp. taurica: Analytical Characterization and Biological Activities

Aromatic Medicinal Plants of the Lamiaceae Family from Uzbekistan: Ethnopharmacology, Essential Oils Composition, and Biological Activities

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