Ziziphora clinopodioides Lam leaves aqueous extract mediated synthesis of zinc nanoparticles and their antibacterial, antifungal, cytotoxicity, antioxidant, and cutaneous wound healing properties under in vitro and in vivo conditions

Abstract

LamZiziphora clinopodioides Biosynthesis of metal nanoparticles using plant medicine is under exploration is due to wide biomedica applications and research interest in nanotechnology, the recent study was assessing green synthesis of zinc nanoparticle using ), the use of plant material Ziziphoraleaves extract (ZnNPs@ not only makes the process eco-friendly but also the abundance makes it more economical. Also, in this study, Vis. and-were characterized using different techniques including UVZiziphora were synthesized in aqueous medium using the plant extract as stabilizing and reducing agents. The synthesized ZnNPs@Ziziphora conditions. ZnNPs@in vivo and in vitro under Ziziphorawe investigated the therapeutical properties of ZnNPs@ FT-IR spectroscopy, . SEM images exhibited a uniform spherical morphology in size of 32.34 Thermal Gravimetric Analysis (TGA)ray diffraction (XRD), scanning electron microscopy (SEM), and Energy Dispersive X-ray Spectrometry (EDS), and-X Escherichia coli, and Pseudomonas aeruginosa, Salmonella typhimurium part of this study, these nanoparticles indicated excellent antibacterial properties against Gram-negative bacteria (in vitronm for the biosynthesized nanoparticles. In the biological , andCandida krusei, Candida albicans, Candida glabrata), antifungal potentials against Bacillus subtilis, andStaphylococcus aureus, Streptococcus pneumoniaO157:H7) and Grampositive bacteria ( leaves aqueous extract can be used to yield zinc nanoparticles with a significant amount of antibacterial, antifungal, antioxidant, and cutaneous wound healing properties without any cytotoxicity.Z. clinopodioides ointment ameliorated the cutaneous wounds with increasing the levels of wound contracture, vessel, hydroxyl proline, hexosamine, hexuronic acid, fibrocyte, and fibrocytes/fibroblast rate and decreeing the wound area, total cells, and lymphocyte compared to other groups in rats. The results of UV, FT-IR, XRD, FE-SEM, EDS, and TGA confirm that the Ziziphora part of our

Suppressor capacity of iron nanoparticles biosynthesized using Salvia chloroleuca leaf aqueous extract on methadone‐induced cell death in PC12: Formulation a new drug from relationship between the nanobiotechnology and neurology sciences

“…One option for enhancing the antioxidant effect of plants is combining them with metallic salts that are called herbal nanoparticles. In the previous experiments have been revealed when plants are combined with gold, silver, titanium, copper, zinc, and iron, their antioxidant properties raise significantly . So far, many plants such as Eucalyptus globulus , Ulex europaeus , Castanea sativa , and Pinus pinaster have been synthesized using iron salt (FeNPs) with remarkable antioxidant effects .…”

“…It seems that FeNPs, due to its anti‐oxidant potential, reduced the cell cytotoxicity in neuron‐like cells. Today, anti‐oxidants are introduced as a reducer of cell cytotoxicity because they inhibit the reactive oxygen species production and oxidative stresses in the cells …”

“…These so called artificially stimulated cells are used in tissue engineering, which might revolutionize the transplantation of organs or artificial implants . Metallic nanoparticles as common production of nanotechnology science, have a high fraction of atoms, which holds striking catalytic, electromagnetic, and antimicrobial effects . Metallic nanoparticles such as iron, gold, cobalt, zinc oxide, silver, and platinum are commonly applied in cancer diagnosis and treatment, and used in the molecular detection of pathogenic microbes and as antibacterial, antifungal, antiviral, antiparasitic, anti‐inflammatory, and antioxidant agents .…”

“…[1,2] Recently, scientist have tried to increase the nanotechnology productions for the treatment many diseases. [2][3][4] Nano-medicine makes use of nano materials, and nano electronic biosensors. In the future, nano medicine will benefit molecular nanotechnology.…”

“…[1] Metallic nanoparticles as common production of nanotechnology science, have a high fraction of atoms, which holds striking catalytic, electromagnetic, and antimicrobial effects. [2,3] Metallic nanoparticles such as iron, gold, cobalt, zinc oxide, silver, and platinum are commonly applied in cancer diagnosis and treatment, and used in the molecular detection of pathogenic microbes and as antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory, and antioxidant agents. [1] The excellent microbial property of iron has resulted in its use in several applications including diaper rashes and allergic diaper rashes, creams for skin blisters, and antiseptic powders.…”