Phenobarbital loaded microemulsion: development, kinetic release and quality control

Figueiredo, Kayo Alves; Neves, Jamilly Kelly Oliveira; Silva, José Alexsandro da; Freitas, Rivelilson Mendes de; Carvalho, André Luís Menezes

doi:10.1590/s1984-82502016000200003

Cited by 18 publications

(11 citation statements)

References 42 publications

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“…Thermal tests are the second stage of accelerated of stability tests. Formulations were put in the water bath at 40 °C the temperature was increased 10 °C every 30 minutes till 80 °C (Figueiredo, 2016). The formulations were evaluated in terms of appearance after returning to room temperature (25±2 °C).…”

Section: Physical Characterization Of Mesmentioning

confidence: 99%

Development and Characterization of Nano-Sized Emulsion Systems Incorporated Polyphenolic Compound for Application Through the Skin

SAMANCI¹,

Yener²,

Değim³

2022

Fabad Journal of Pharmaceutical Sciences

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In addition to having strong anti-oxidant properties, resveratrol has anti-cancer, anti-angiogenic, cardioprotective, anti-diabetic, antiviral, and neuroprotective activities. Despite its rapid absorption, first-pass effect and intestinal metabolism reduce the bioavailability of resveratrol. Moreover, the lipophilic property of resveratrol reduces its water solubility and metabolized in high incidence reduces its oral bioavailability. Therefore, it was aimed to develop an optimum formulation for the skin application of resveratrol to overcome the negatives after oral administration.Since their easy formulation, thermodynamically stable properties, and facilitating the delivery of both lipophilic and hydrophilic active ingredients, loading resveratrol to microemulsions (MEs) will be a suitable delivery system to overcome the drawback of stability problems and skin bioavailability of resveratrol. A Triangle phase diagram was constructed, and the MEs region was determined by points studies. Subsequently, some formulations were selected within the transparent region by considering characteristics required to achieve optimized transdermal drug delivery. Chosen formulations were exposed to pre-stability tests such as centrifuge and thermal stress tests. Characterization studies such as droplet size, size distribution, zeta potential, viscosity, pH measurement were performed on remained intact formulations after pre-stability tests. In terms of the characterization test results such as pH, viscosity, conductivity, there wasn't found significant difference observed between formulations. However, polydispersity index and zeta potential values provided to choosing optimal formulation.

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Section: Physical Characterization Of Mesmentioning

confidence: 99%

Development and Characterization of Nano-Sized Emulsion Systems Incorporated Polyphenolic Compound for Application Through the Skin

SAMANCI¹,

Yener²,

Değim³

2022

Fabad Journal of Pharmaceutical Sciences

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“…The aliquots absorption was measured using a spectrophotometer (Shimadzu UV-1800) at the maximum wavelength of IBP (223 nm). The receptor phase was replaced at each sampling time by 5.0 mL of phosphate buffer solution (Figueiredo et al, 2016;Priani et al, 2018). This experiment was done in triplicate replication.…”

Section: In-vitro Diffusion Study Of Nanogelmentioning

confidence: 99%

In-vitro diffusion study of ibuprofen--cyclodextrin inclusion complex nanogel

et al. 2021

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The inclusion complex is one way to enhance active substance solubility, affecting medicine dissolution and penetration. The inclusion complex is formed by utilizing -cyclodextrin as the host of the active compounds. The Ibuprofen (2-(4-isobutyl-phenyl)propionate) is a propionate acid derivative and classified in class II of the Biopharmaceutic Classification System, which has low dissolutions and high permeability. This study aims to develop a nanogel containing ibuprofen-β-cyclodextrin inclusion complex with the ratio of 1:1, 1:2 and 2:1; and to compare the in-vitro diffusion profile with pure ibuprofen gel. The inclusion complex of ibuprofen-β-cyclodextrin was prepared using the coprecipitation method with the three molar comparison ratio of 1:1, 1:2, and 2:1. The in-vitro study was performed using the gel-based viscolam, comparing the three formulas of ibuprofen-βcyclodextrin with pure ibuprofen gel. The ibuprofen concentration of each gel tested in the experiment was 1%. The particle size characterization of ibuprofen-β-cyclodextrin inclusion complex gel resulted in having nanoparticle size (510 nm). This characteristic indicates that the inclusion complex gel could enhance the cumulative release amount of ibuprofen compared with pure ibuprofen gel with a relatively smaller particle size (156 nm). Pure ibuprofen and inclusion complex powder size measured to be 763 nm and 957 nm, respectively. The ibuprofen--cyclodextrin inclusion complex gel with a molar ratio of 2:1 demonstrated an increase in in-vitro diffusion profile of ibuprofen with a cumulative release amount of 740.3 µg.cm -2 . Meanwhile, pure ibuprofen gel had the cumulative release amount of 294.74 µg.cm -2 . The gel containing ibuprofen-β-cyclodextrin inclusion complex could enhance the cumulative release amount of ibuprofen compared to pure ibuprofen gel. The ibuprofen-β-cyclodextrin inclusion complex gel at a ratio of 2:1 exhibited an increase in the diffusion of ibuprofen in-vitro.

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“…Phenobarbital: 2016 Phenobarbital loaded microemulsion for a transdermal drug delivery application [ 371 ]; energy contributions from competing hydrogen-bonded structures in six polymorphs of phenobarbital [ 372 ]; application of Ni:ZnS nanoparticles loaded on magnetic multi-walled carbon nanotubes as a sorbent for dispersive micro-solid phase extraction of phenobarbital and phenytoin prior to HPLC analysis of plasma, urine and water samples [ 373 ]; 2017 development of an electrochemical sensor based on the reduced graphene oxide/Pt nanopartides nanocomposite immobilized on modified glassy carbon electrode for the determination of phenobarbital and droxidopa [ 374 ]; preferential solvation parameters of phenobarbital in aqueous binary mixtures of 1,4-dioxane, t-butanol, n-propanol, ethanol, propylene glycol and glycerol were derived using the IKBI method [ 375 ]; application of a CaWO4 semiconductor to the phenobarbital electro-photocatalysis under UV/C irradiation [ 376 ]; 2018 SERS method for the quantitative detection of Phenobarbital in an injectable solution [ 377 ]; modified dispersive liquid phase microextraction for simultaneous separation/preconcentration of trace amounts of phenobarbital and phenytoin [ 378 ]; 2019 fluorescence sensor for the detection of phenobarbital [ 379 ].…”

Section: Routine and Improved Analyses Of Abused Substancesmentioning

confidence: 99%