Phenmetrazine Hydrochloride and Methylcellulose in the Treatment of "Refractory" Obesity

Effects of a Cereal Rich in Soluble Fiber on Body Composition and Dietary Compliance during Consumption of a Hypocaloric Diet

“…There are no known published trials investigating these issues in which soluble fiber has been provided as an intrinsic component of food during a hypocaloric diet. As summarized elsewhere [6], previous studies on soluble fiber and weight loss [3,4,[7][8][9][10][11][12][13][14][15][16] have yielded inconsistent results, possibly due to the effect of uncontrolled differences between studies such as study duration, protocol, compliance with study diets, amount and type of fiber and how incorporated into the diet, and dietary macronutrient content. There are insufficient numbers of trials to establish if soluble fiber as a food component benefits body weight, and the trials of soluble supplements do not support a clear dose-response relationship.…”

“…There is currently controversy over whether soluble fiber can aid weight loss [6], with some studies showing a positive effect of fiber on weight loss [3,4,[7][8][9][10][11][12] and others showing no effect [4,9,[13][14][15][16]. It is possible that these inconsistent results may be due to differences in study protocols, as well as the type, amount and physical form of fiber utilized.…”

Treatment of refractory obesity with fenfluramine.

“…All were clinically obese, overweight by at least 20% of their standard (U.S.A. Medico-Actuarial Investigation, 1912), and had " refractory obesity " as previously defined (Duncan et al, 1960). Thus they had regularly attended the Diabetic and Dietetic Department during the previous year for dietetic advice and supervision, but had not lost weight appreciably in the three months before the study or taken any anorectic drug in the previous six months.…”

Bulking Agents in the Treatment of Obesity

“…Yudkin (1959) demonstrated that methylcellu lose ingested 30 min before meals reduced food intake and encouraged weight loss in human volunteers. Duncan et al (1960) found methylcellulose ineffective as an appetite depressant in the treatment of obese patients, however, the dose used was less than half (4.5 g/day) that found to be effective by Yudkin (1959) (lOg/day). The recommended dose for methylcellulose is 1 X 5 ml spoonful granules (2 g) or 3 tablets (1.5 g) half an hour before a meal.…”