Phase Tomography by X-ray Talbot Interferometry for Biological Imaging

Momose, Atsushi; Yashiro, Wataru; Takeda, Yoshihiro; Suzuki, Yoshio; Hattori, Tadashi

doi:10.1143/jjap.45.5254

Cited by 292 publications

(228 citation statements)

References 39 publications

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“…By using the experimentally obtained ∆δ, the density resolution of the system was estimated [5]. In the present case, the density resolution corresponds to the sensitivity limit determined by the noise level in the CCD.…”

Section: X-ray Phase Contrst Tomography Of Mouse Whole Eyementioning

confidence: 91%

Investigation of Imaging Properties of Mouse Eyes Using X-ray Phase Contrast Tomography

Hoshino¹,

Uesugi²,

Yagi³

et al. 2010

AIP Conference Proceedings

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Abstract. The structure of a whole eye of mouse was studied with an X-ray Talbot grating interferometer. The distribution of crystallin concentration in the lens was quantitatively measured by X-ray phase contrast tomography. A new technique to measure the crystallin concentration in the lens is proposed. By using the proposed method, the gradient of crystallin concentration in the lens was estimated. A ray-trace of a mouse whole eye was performed with the refractive indices derived from the crystallin concentration.

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Section: X-ray Phase Contrst Tomography Of Mouse Whole Eyementioning

confidence: 91%

Investigation of Imaging Properties of Mouse Eyes Using X-ray Phase Contrast Tomography

Hoshino¹,

Uesugi²,

Yagi³

et al. 2010

AIP Conference Proceedings

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“…This imaging modality is well known from visible-light microscopy, 1 but it is quite new in the field of x-ray imaging. [2][3][4][5][6][7][8] For a long time, these methods have been practically limited to highly brilliant radiation as it is available at, e.g., synchrotron radiation sources. Recently, the development of grating interferometers extended x-ray phase-contrast imaging even to conventional x-ray tube sources, [9][10][11] making the grating-based x-ray phase-contrast imaging feasible also at low-coherent second generation synchrotron radiation sources.…”

Section: Introductionmentioning

confidence: 99%

X-ray grating interferometer for materials-science imaging at a low-coherent wiggler source

Herzen

Donath²,

Beckmann³

et al. 2011

Review of Scientific Instruments

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Endstation for ultrafast magnetic scattering experiments at the free-electron laser in Hamburg Rev. Sci. Instrum. 84, 013906 (2013) Impact system for ultrafast synchrotron experiments Rev. Sci. Instrum. 84, 013904 (2013) A digital miniature x-ray tube with a high-density triode carbon nanotube field emitter Appl. Phys. Lett. 102, 023504 (2013) Active diffraction gratings: Development and tests Rev. Sci. Instrum. 83, 123106 (2012) Orientation-selective X-ray dark field imaging of ordered systems J. Appl. Phys. 112, 114903 (2012) Additional information on Rev. Sci. Instrum. X-ray phase-contrast radiography and tomography enable to increase contrast for weakly absorbing materials. Recently, x-ray grating interferometers were developed that extend the possibility of phasecontrast imaging from highly brilliant radiation sources like third-generation synchrotron sources to non-coherent conventional x-ray tube sources. Here, we present the first installation of a three grating x-ray interferometer at a low-coherence wiggler source at the beamline W2 (HARWI II) operated by the Helmholtz-Zentrum Geesthacht at the second-generation synchrotron storage ring DORIS (DESY, Hamburg, Germany). Using this type of the wiggler insertion device with a millimeter-sized source allows monochromatic phase-contrast imaging of centimeter sized objects with high photon flux. Thus, biological and materials-science imaging applications can highly profit from this imaging modality. The specially designed grating interferometer currently works in the photon energy range from 22 to 30 keV, and the range will be increased by using adapted x-ray optical gratings. Our results of an energy-dependent visibility measurement in comparison to corresponding simulations demonstrate the performance of the new setup.

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“…Numerous researches have studied a variety of methods of achieving phase imaging with X-ray gratings [1][2][3][4][5] . X-ray Talbot interferometer (XTI) 1 is one of the methods.…”

Section: Introductionmentioning

confidence: 99%

“…We had first succeeded in fabricating with 20 mm × 20 mm area and 8 µm pitch structure by X-ray lithography and electroplating techniques 7,8 . Then, we obtained the phase tomography imaging 3 . In this paper, we discuss the X-ray grating having a pitch of 5.3 µm and a large effective area of 60 mm × 60 mm and more.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of High Aspect Ratio X-ray Grating Using X-ray Lithography

Noda

Tsujii

Shimada

et al. 2009

JMMP

Self Cite

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X-ray radiographic imaging technique has found applications in various fields. However, it is not enough to get clear X-ray images of samples with low absorbance, such as biological soft tissues. To resolve this problem, we proposed a method using an X-ray Talbot interferometer of X-ray phase imaging. In this X-ray Talbot interferometer, X-ray gratings were required to have a fine, high accuracy, high aspect ratio structure. Then, we have developed and succeeded high aspect ratio X-ray gratings with a pitch of 5.3 µm and a height of 30 µm using X-ray lithography technique. We discuss that the X-ray gratings having a large effective area in order to obtain imaging size of practical use in medical application. In currently study, we have fabricated the X-ray gratings with a large effective area of 60 mm × 60 mm. And, we conducted X-ray phase tomography of mouse at the chest and abdominal using X-ray Talbot interferometer. As a result, we successfully observed soft tissues and high density tissues. With the aim of broadening a field of view, we try to fabricate X-ray gratings that have a pitch of below 5.3 µm and larger area of 100 mm square. This result suggests that X-ray Talbot interferometer is a novel and simple method for phase sensitive X-ray radiography.

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Phase Tomography by X-ray Talbot Interferometry for Biological Imaging

Cited by 292 publications

References 39 publications

Investigation of Imaging Properties of Mouse Eyes Using X-ray Phase Contrast Tomography

Investigation of Imaging Properties of Mouse Eyes Using X-ray Phase Contrast Tomography

X-ray grating interferometer for materials-science imaging at a low-coherent wiggler source

Fabrication of High Aspect Ratio X-ray Grating Using X-ray Lithography

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