X-ray grating interferometer for materials-science imaging at a low-coherent wiggler source

Herzen, Julia; Donath, Tilman; Beckmann, Felix; Ogurreck, Malte; Dávid, Christian; Mohr, Jürgen; Pfeiffer, Franz; Schreyer, A.

doi:10.1063/1.3662411

Cited by 26 publications

(15 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The phase tomography measurements were carried out using a Talbot-Lau interferometer at the beamline W 2 (HASYLAB at DESY, Hamburg, Germany), operated by the HZG Research Center [6,9]. The grating interferometer consisted of three gratings: the source grating (period 22.9 µm; gold height 130 µm), the phase grating (period 4.33 µm; silicon height about 60 µm) and the analyzer grating (period 2.4 µm; gold height: 150 µm).…”

Section: Mouse Aortasmentioning

confidence: 99%

Morphology of atherosclerotic coronary arteries

et al. 2012

Self Cite

View full text Add to dashboard Cite

Atherosclerosis, the narrowing of vessel diameter and build-up of plaques in coronary arteries, leads to an increase in the shear stresses present, which can be used as a physics-based trigger for targeted drug delivery. In order to develop appropriate nanometer-size containers, one has to know the morphology of the critical stenoses with isotropic micrometer resolution. Micro computed tomography in absorption and phase contrast mode provides the necessary spatial resolution and contrast. The present communication describes the pros and cons of the advanced laboratory and synchrotron radiation-based approaches in the visualization of diseased human and murine arteries. Using registered datasets, it also demonstrates that multi-modal imaging, including established histology, is even more powerful. The tomography data were evaluated with respect to cross-section, vessel radius and maximal constriction. The average cross-section of the diseased human artery (2.31 mm 2 ) was almost an order of magnitude larger than the murine one (0.27 mm 2 ), whereas the minimal radius differs only by a factor of two (0.51 mm versus 0.24 mm). The maximal constriction, however, was much larger for the human specimen (85% versus 49%). We could also show that a plastic model used for recent experiments in targeted drug delivery represents a very similar morphology, which is, for example, characterized by a maximal constriction of 82%. The tomography data build a sound basis for flow simulations, which allows for conclusions on shear stress distributions in stenosed blood vessels.

show abstract

Section: Mouse Aortasmentioning

confidence: 99%

Morphology of atherosclerotic coronary arteries

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…The method has been extended from radiographic to tomographic imaging and successfully adapted to operate with laboratory X-ray sources shortly after [3,4]. As a consequence of these developments, a broad use for medical applications, biological examinations, material characterization or food testing is meanwhile under investigation [5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Quantitative X-ray phase-contrast computed tomography at 82 keV

Willner¹,

Bech²,

Herzen³

et al. 2013

Opt. Express

Self Cite

View full text Add to dashboard Cite

Potential applications of grating-based X-ray phase-contrast imaging are investigated in various fields due to its compatibility with laboratory X-ray sources. So far the method was mainly restricted to X-ray energies below 40 keV, which is too low to examine dense or thick objects, but a routine operation at higher energies is on the brink of realisation. In this study, imaging results obtained at 82 keV are presented. These comprise a test object consisting of well-defined materials for a quantitative analysis and a tooth to translate the findings to a biomedical sample. Measured linear attenuation coefficients ? and electron densities ?e are in good agreement with theoretical values. Improved contrast-to-noise ratios were found in phase contrast compared to attenuation contrast. The combination of both contrast modalities further enables to simultaneously assess information on density and composition of materials with effective atomic numbers Z? > 8. In our biomedical example, we demonstrate the possibility to detect differences in mass density and calcium concentration within teeth.

show abstract

“…It can be used to characterize material interfaces as well as internal density gradients, thus making it an attractive tool for a wide range of applications in material science, energy research, biomedical imaging, and High Energy Density (HED) plasma studies. [1][2][3][4][5][6][7][8] The TL interferometer can be adapted from a standard medical setup 8 according to the requirements of HED experiments, 6 particularly for Inertial Confinement Fusion (ICF) 9 diagnostics. ICF capsules are compressed from a few millimeters diameter to a tens of microns diameter hot spot, hence creating high density regions with sharp gradients; thus, the description of a typical HED plasma feature requires a spatial resolution of $10 lm, achievable by means of large object magnifications.…”

mentioning

confidence: 99%

Talbot-Lau based Moiré deflectometry with non-coherent sources as potential High Energy Density plasma diagnostic

Valdivia

Stutman

Finkenthal

2013

Journal of Applied Physics

View full text Add to dashboard Cite

X-ray phase-contrast radiography could better characterize highly localized density gradients expected in High Energy Density (HED) plasma experiments than conventional attenuation radiography. In particular, the Talbot-Lau (TL) grating interferometer, which works with extended and polychromatic x-ray sources, is a potentially attractive HED diagnostic due to its high sensitivity. For HED characterization the TL setup and imaging techniques must be changed from the recently studied medical system. The object magnification must be increased greatly in order to resolve μm scale gradients while the Talbot magnification must be increased in order to keep the gratings away from the plasma. Additionally, techniques for retrieving the density profile from a single plasma image must be developed. We thus study the performance of high magnification TL interferometers, in conjunction with Moiré fringe deflectometry for single image phase retrieval. The results show a very good interferometer contrast (≤30%) at high magnification. The Moiré technique enables measuring both sharp and mild density gradients with good accuracy and spatial resolution. Both the laboratory and simulation studies indicate that the TL based Moiré deflectometry is more sensitive than the propagation phase-contrast method when utilizing an extended x-ray source (∼80 μm). In HED experiments this would allow for less demanding X-ray backlighters than those used at present.

show abstract

X-ray grating interferometer for materials-science imaging at a low-coherent wiggler source

Cited by 26 publications

References 28 publications

Morphology of atherosclerotic coronary arteries

Morphology of atherosclerotic coronary arteries

Quantitative X-ray phase-contrast computed tomography at 82 keV

Talbot-Lau based Moiré deflectometry with non-coherent sources as potential High Energy Density plasma diagnostic

Contact Info

Product

Resources

About