2017
DOI: 10.3390/s17122819
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Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects

Abstract: Surface plasmon resonance (SPR) is an optical sensing technique that is capable of performing real-time, label-free and high-sensitivity monitoring of molecular interactions. SPR biosensors can be divided according to their operating principles into angle-, wavelength-, intensity- and phase-interrogated devices. With their complex optical configurations, phase-interrogated SPR sensors generally provide higher sensitivity and throughput, and have thus recently emerged as prominent biosensing devices. To date, s… Show more

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Cited by 73 publications
(49 citation statements)
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“…The optical field of the SPs decays exponentially on both sides of the dielectric/metal interface. Consequently, the SPR phenomenon [ 4 , 9 ] related to the generation of the surface plasmon polaritons (SPPs) and propagation of the surface plasmon wave (SPW) along the dielectric/metal interface, is accompanied by a drop in the reflected intensity [ 4 ], or by a phase change [ 10 , 11 ], and thus it is attractive to sensing in various fields of interest [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], especially in biosensing [ 4 , 15 , 16 , 17 , 18 ]. To these measurements, performed in angular or spectral domain, correspond angular or wavelength interrogations.…”
Section: Introductionmentioning
confidence: 99%
“…The optical field of the SPs decays exponentially on both sides of the dielectric/metal interface. Consequently, the SPR phenomenon [ 4 , 9 ] related to the generation of the surface plasmon polaritons (SPPs) and propagation of the surface plasmon wave (SPW) along the dielectric/metal interface, is accompanied by a drop in the reflected intensity [ 4 ], or by a phase change [ 10 , 11 ], and thus it is attractive to sensing in various fields of interest [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], especially in biosensing [ 4 , 15 , 16 , 17 , 18 ]. To these measurements, performed in angular or spectral domain, correspond angular or wavelength interrogations.…”
Section: Introductionmentioning
confidence: 99%
“…To monitor the shift of the SPR dip, different types of SPR interrogation technologies have been developed, such as intensity interrogation, angular interrogation, spectral interrogation and phase interrogation [4][5][6]. Compared with other SPR technologies, the phase interrogation SPR technique has the highest sensitivity, reaching up to between 10 −8 and 10 −9 RIU.…”
Section: Introductionmentioning
confidence: 99%
“…Optical phase detection techniques [21][22][23] provide a large number of approaches, including heterodyne interferometry [24,25], interferometry with a Mach-Zehnder [12,[26][27][28] or imaging interferometer [13], phase quadrature interferometry [29], a phase-shifted polarimetric scheme [30], schemes with a photo-elastic [14] or electro-optic [15] modulator, and a rotating analyzer method [17]. Recently, techniques of spectral interferometry [18][19][20]31,32] and holographic microscopy [33] have emerged as effective tools too.…”
Section: Introductionmentioning
confidence: 99%