Pharyngoconjunctival fever caused by adenovirus type 11

Molecular Epidemiology and Brief History of Emerging Adenovirus 14–Associated Respiratory Disease in the United States

“…attributed to HAdV-11 [33][34][35][36]. The Taiwanese HAdV-B2 isolates examined in the present study were originally reported as HAdV-14 [10], but they proved to be HAdV-11a, with hexon, fiber, and E1A region sequences almost identical to those obtained for other Asian HAdV-11a strains [23,37].…”

Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention

“…AdV-11 is relatively uncommon, but may cause hemorrhagic conjunctivitis [45][46][47]81 and FRI (including pneumonia) in immunocompetent patients and HC in immunocompromised patients. 21,81 In the United States from 2004 to 2006, AdV-11 accounted for < 1% of AdV RTI in military recruits and civilians 161 ; in Toronto, Canada, AdV-11 was not detected among 96 clinical respiratory AdV isolates (►Table 1).…”

Outbreak of Febrile Respiratory Illness Associated with Adenovirus 11a Infection in a Singapore Military Training Camp

“…The HAdV serotypes most frequently associated with ARD in both military and civilian communities include subspecies B1 HAdV-3, HAdV-7, and HAdV-21 and species E HAdV-4. The association of subspecies B2 HAdV infection with ARD has historically been rarely reported and restricted mostly to closed community outbreaks, some of which were documented among military trainees (1,2,8,24,36).…”

“…The results of this study suggest that, in contrast to other geographic locations where HAdV-3, -4, -7, and -21 rank among the most prevalent serotypes, HAdV-11 may be a relatively more important causative agent of ARD in military training facilities in Singapore. The circulation of HAdV-11 in South East Asia has been documented since the early 1960s in association with conjunctivitis, pharyngoconjuctival fever, ARD, and hemorrhagic cystitis among immunocompromised individuals (7,9,14,17,24,31,(34)(35)(36). The work of Wadell and colleagues demonstrated the existence of two main clusters of relative homology for HAdV-11 genome types: the cluster of prototype-like genomic variants with a tropism for the renal epithelium, and the a-like cluster, with a distinct tropism for the respiratory tract.…”