Pharmakochemische Untersuchungen Von Drogen Der Gattung Passiflora

Lutomski, J.; Malek, B.

doi:10.1055/s-0028-1097789

Cited by 8 publications

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“…Little is known about the mechanism(s) of action of P. incarnata extracts. A few P. incarnata species have been chemically investigated and products such as flavonoids (3,4,5), -carboline alkaloids (6,7,8,9), cyanogenic glycosides (10), and terpene derivatives (11,12,13) have been identified. Nevertheless, the active principles responsible for the neuropharmacological properties have still not been recognized.…”

Section: Introductionmentioning

confidence: 99%

Neuropharmacological Activity of Extracts fromPassiflora incarnata

Speroni

Minghetti

1988

Planta Med

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A fluid extract of Passiftora incarnata L. was studied for its neuropharmacologieal properties. This extract, orally and intraperitoneally administered to rats, raised the nociceptive threshold in the tail-flick and hot-plate tests, but not in the vocalization test. On intraperitoneal injection, the extract significantly prolonged sleeping time, protected animals from the convulsive effect of pentylenetetrazole, and affected locomotor activity. The fluid extract was partitioned by solvents and chromatography and at least two products, one lipophilic (A) and one hydrophilic (B), were found to be active. They could not be ascribed to either alkaloids or the flavonoid structures present in the extract.

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Section: Introductionmentioning

confidence: 99%

Neuropharmacological Activity of Extracts fromPassiflora incarnata

Speroni

Minghetti

1988

Planta Med

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Comparative pharmacological study of hydroethanol extracts of Passiflora alata and Passiflora edulis leaves†

Petry

Reginatto

de‐Paris

et al. 2001

Phytotherapy Research

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Comparative metabolite profiling and fingerprinting of genus Passiflora leaves using a multiplex approach of UPLC-MS and NMR analyzed by chemometric tools

et al. 2016

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Passiflora incarnata as well as some other Passiflora species are reported to possess anxiolytic and sedative activity and to treat various CNS disorders. The medicinal use of only a few Passiflora species has been scientifically verified. There are over 400 species in the Passiflora genus worldwide, most of which have been little characterized in terms of phytochemical or pharmacological properties. Herein, large-scale multi-targeted metabolic profiling and fingerprinting techniques were utilized to help gain a broader insight into Passiflora species leaves' chemical composition. Nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) spectra of extracted components derived from 17 Passiflora accessions and from different geographical origins were analyzed using multivariate data analyses. A total of 78 metabolites were tentatively identified, that is, 20 C-flavonoids, 8 O-flavonoids, 21 C, O-flavonoids, 2 cyanogenic glycosides, and 23 fatty acid conjugates, of which several flavonoid conjugates are for the first time to be reported in Passiflora spp. To the best of our knowledge, this study provides the most complete map for secondary metabolite distribution within that genus. Major signals in (1)H-NMR and MS spectra contributing to species discrimination were assigned to those of C-flavonoids including isovitexin-2″-O-xyloside, luteolin-C-deoxyhexoside-O-hexoside, schaftoside, isovitexin, and isoorientin. P. incarnata was found most enriched in C-flavonoids, justifying its use as an official drug within that genus. Compared to NMR, LC-MS was found more effective in sample classification based on genetic and/ or geographical origin as revealed from derived multivariate data analyses. Novel insight on metabolite candidates to mediate for Passiflora CNS sedative effects is also presented.

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Pharmakochemische Untersuchungen Von Drogen Der Gattung Passiflora

Cited by 8 publications

References 0 publications

Neuropharmacological Activity of Extracts fromPassiflora incarnata

Neuropharmacological Activity of Extracts fromPassiflora incarnata

Comparative pharmacological study of hydroethanol extracts of Passiflora alata and Passiflora edulis leaves†

Comparative metabolite profiling and fingerprinting of genus Passiflora leaves using a multiplex approach of UPLC-MS and NMR analyzed by chemometric tools

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