1962
DOI: 10.1111/j.1476-5381.1962.tb01145.x
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Pharmacological Study and Fractionation of Paspalum Scrobiculatum Extract

Abstract: The dried ethanol extract of the husk of the grain of Paspalum scrobiculatum produced tranquillization and tremors in various species of animals. It potentiated the effect of hexobarbitone in mice, produced hypothermia in mice and rats and enhanced leptazol toxicity in rats. Amphetamine group-toxicity in mice increased after injecting the extract or an emulsion containing a similar quantity of olive oil. Vomiting in pigeons and decrease of morphine rage in cats were noted. Diminution of carotid occlusion refle… Show more

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Cited by 14 publications
(6 citation statements)
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“…Porridge, chapatti (flat cake or bread made from flour), sprouted grains, dosa (a thin fermented pancake containing blackgram), and popped grains are some of the most common foods prepared from the millets (Dwivedi et al, 2012 and references therein). Both fungi produce cyclopiazonic acid, which causes kodua poisoning (Rao and Husain, 1985), which results in sleepiness, tremors, and giddiness in humans (Bhide, 1962). To date, no antinutrients from barnyard and kodo millets have been reported.…”
mentioning
confidence: 99%
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“…Porridge, chapatti (flat cake or bread made from flour), sprouted grains, dosa (a thin fermented pancake containing blackgram), and popped grains are some of the most common foods prepared from the millets (Dwivedi et al, 2012 and references therein). Both fungi produce cyclopiazonic acid, which causes kodua poisoning (Rao and Husain, 1985), which results in sleepiness, tremors, and giddiness in humans (Bhide, 1962). To date, no antinutrients from barnyard and kodo millets have been reported.…”
mentioning
confidence: 99%
“…However, kodua poisoining was reported when kodo millet grains infected with Aspergillus flavus or A. tamarii were used as food or feed. Both fungi produce cyclopiazonic acid, which causes kodua poisoning (Rao and Husain, 1985), which results in sleepiness, tremors, and giddiness in humans (Bhide, 1962).…”
mentioning
confidence: 99%
“…PCA9 was effective in reducing amphetamine-induced hypera ctivity though it did not prevent the toxicity in aggregated mice. However, similar ob servations have been reported for some neuroleptics (21,22). PCA9 showed specific block of the conditioned avoidance response in rats and sup pressed fighting behaviour in mice; the ED50s for these effects were much lower than the ED,, which impaired coordinated motor activity (Table 4) These actions of PCA9 simu late those of major tranquillizers (chlorpromazine and reserpine) which have been report ed to block CAR in rats (10) and suppress fighting behaviour in mice (23,24).…”
Section: Acute Toxicitymentioning
confidence: 93%
“…It induces degenerative necrosis of the liver, pancreas, spleen, kidney, salivary gland, muscle, and myocardium in rats (Morrisey, Norred, Cole, & Dorner, 1985). It has also been associated with human poisoning (Rao & Husain, 1985), such as moldy corn toxicosis, known as "Kodua poisoning" (Bhide, 1962). This non-lethal disease in humans is characterized by sleeplessness, tremors, and giddiness (Rao & Husain, 1985).…”
Section: Sample Fungal Count (Cfu/g) Fungal Species Isolated 5°c 25°cmentioning
confidence: 99%