Pharmacological Stimulation of the Regenerative Capacity of Rat Testes Damaged by Paclitaxel

Abstract

Productivity of spermatogenesis and the population of spermatogonial cells were substantially reduced in male Wistar rats 3 months after administration of cytostatic drug paclitaxel, damaging stem spermatogonia. However, signs of reparative regeneration appeared in the testicular tissue. In animals receiving paclitaxel in combination with granulocyte CSF, the same period of observation, the number of spermatogonia and the efficiency of spermatogenesis at the same terms of the study did not differ from those in intact animals. Intensive recovery processes started 1 month earlier than after administration of paclitaxel alone. These data attest to pronounced potentiating effect of granulocyte CSF on reparative regeneration of the testicular tissue.

Achillea millefolium alleviates testicular damage in paclitaxel‐intoxicated rats via attenuation of testicular oxido‐inflammatory stress and apoptotic responses

“…Male germ cells, which have one of the highest physiological regeneration rates, are highly sensitive to the toxic effects of anticancer drugs that adversely affect spermatogenesis. Furthermore, testicular tissue demonstrates very little ability for reparative regeneration as microenvironment cells (Sertoli cells) do not proliferate in mature curved seminiferous tubules (Borovskaya et al., 2014). Previous studies have reported that paclitaxel induces abnormal changes in sperm activity, motility and density, as well as testicular DNA fragmentation, oxidative stress and apoptosis (Abd‐Elrazek et al., 2020).…”