Gilaburu (Viburnum opulus L.) fruit extract alleviates testis and sperm damages induced by taxane-based chemotherapeutics

Treatment with melatonin and selenium attenuates docetaxel‐induced apoptosis and oxidative injury in kidney and testes of mice

“…In the present study, we indicated that LPx and ROS levels in the tissues were up‐regulated in mice by DTX. The increase of testes LPx levels after DTX was reported in the rats (Altintas et al, ; Sarıözkan et al, ), and the current LPx and ROS results confirmed these reports. However, we observed for first time that the DTX‐induced increases in LPx and ROS levels in both tissues were diminished in mice by the MEL and Se treatments.…”

“…Similarly, Ateşşahin et al, () demonstrated that cisplatin treatment caused a reduction of R‐GSH level and GSHPx activity in testes of rats. Decreased GSHPx activity and R‐GSH level were also reported in testes of DTX‐treated rats (Altintas et al, ; Sarıözkan et al, ).…”

“…Furthermore, accumulating evidence has suggested that cisplatin‐induced oxidative damage to the testis (Ateşşahin et al, ; Ilbey et al, ) and kidney (Mercantepe, Mercantepe, Topcu, Yılmaz, & Tumkaya, ) can be diminished after MEL treatment. The protective effects of Gilaburu (Sarıözkan et al, ) and quercetin (Altintas et al, ) through up‐regulation of antioxidant redox system on DTX‐induced testis oxidative toxicity in rats were recently reported. However, the protective effects of MEL on DTX‐induced damage to testis and kidney have not been previously clarified.…”

“…In the treatment of prostate cancers, DTX is one of the most effective chemotherapeutic agents (Djeu & Wei, ). However, it can induce several adverse effects in normal tissues, including rat testis (Altintas et al, ; Sarıözkan et al, ). DTX is cleared from the body through the kidney.…”

“…However, the nephrotoxicity and testicular toxicity of DTX have not been fully understood. Some studies suggest that the toxicity of DTX is induced by overproduction of reactive oxygen species (ROS; Altintas et al, ; Baş & Nazıroğlu, ; Sarıözkan et al, ). DTX increases apoptosis through activation of different molecular pathways, including caspase activities such as caspase‐3 (casp‐3) and caspase‐9 (casp‐9) and oxidative stress markers such as peroxidation of lipids and oxidation of glutathione (Djeu & Wei, ; Sarıözkan et al, ).…”