Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review

Adeleke, Bartholomew Saanu; Babalola, Olubukola Oluranti

doi:10.3390/jof7020147

Cited by 92 publications

(72 citation statements)

References 96 publications

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“…The GC-MS analysis of ethyl acetate extracts of endophytic fungi F1 and F2 (control-without adding host plant extract) revealed the presence of compounds like 1-octen-3-ol, 3-methyl-1-butanol, hexanol, trans-2-octanol and hexadecanol in similarity with the host plant extract. These compounds are known to possess antimicrobial, anti-inflammatory and antioxidant activities [44]. Sharing of the above mentioned similar secondary metabolite compounds between endophytic fungi and the host plant has been reported earlier [9,45].…”

Section: Discussionmentioning

confidence: 70%

Secondary Metabolite Production and Terpenoid Biosynthesis in Endophytic Fungi Cladosporium cladosporioides Isolated from Wild Cymbopogon martinii (Roxb.) Wats

Jayaram

Marigowda²,

Saraswathi

2021

Microbiology Research

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Endophytic fungi Cladosporium cladosporioides (F1-MH810309) and Cladosporium tenuissimum (F2-MN715834) from the leaf of wild Cymbopogon martinii (MT90507) were isolated and selected based on the persistent occurrence during different seasons of the year. They were identified based on the morphological features and molecular characterization (ITS sequence), and later deposited at NCBI. Phytochemical studies on F1, F2 and host extracts showed the presence of alkaloids, flavonoids, phenols, terpenoids and tannins. The GC-MS of F1 extract (control) under the axenic condition revealed compounds like hexadecane, heptadecane,2,4-Ditert-butylphenol, E-14 hexadecenal, geraniol, geranyl acetate and cubenol similar to the host. The GC-MS of F2 extract (control) revealed metabolites that were unique. Further, both F1 and F2 were cultured in the supplementation of different concentrations (5%, 10%, 15% and 20%) of the host plant extract (an-axenic condition). The GC-MS of F1 extracts (test) exhibited good growth and showed the gradual increased production of terpenoid compounds whereas the F2 (test) did not show any growth. These compounds such as hyrdoxymenthol, nor-borneol, cedralacetate, α-cyclogeraniol, campesterol, β-cyclogeraniol, linalool oxide,2,3-boranediol, citronellyltiglate and 2,3-pinanediol were produced in a minor quantity and were known as biotransformed forms of the precursor compounds present in the host extract. In comparison, only F1 was able to produce terpenoids similar to the host species both in axenic and an-axenic conditions. Hence from the current study, the endophytic fungus F1 isolated from wild C. martinii for the first time can serve as a better resource for the bioprospection of an important terpenoid and its metabolites.

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Section: Discussionmentioning

confidence: 70%

Secondary Metabolite Production and Terpenoid Biosynthesis in Endophytic Fungi Cladosporium cladosporioides Isolated from Wild Cymbopogon martinii (Roxb.) Wats

Jayaram

Marigowda²,

Saraswathi

2021

Microbiology Research

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“…The biosynthetic pathways of secondary metabolites are manipulated by a group of arranged genes, named biosynthetic gene clusters (BGCs), encoding tandem enzymatic reactions [56,57]. The acyl-coenzyme A enzyme represents the initial point of synthesis of diverse classes of biomolecules including alkaloids, terpenoids, cyclohexanes, peptides, polyketides, flavonoids, hydrocarbons, steroids, monoterpenoids, xanthones, tetralones, quinones and several other compounds endowed with significant activities in vital fields of life [8,[58][59][60][61][62]. The regulation of fungal BGCs occurs at the transcriptional and the epi-genetic levels [23].…”

Section: Processes Of Fungal Secondary Metabolite Productionmentioning

confidence: 99%

“…classes of biomolecules including alkaloids, terpenoids, cyclohexanes, peptides, polyketides, flavonoids, hydrocarbons, steroids, monoterpenoids, xanthones, tetralones, quinones and several other compounds endowed with significant activities in vital fields of life [8,[58][59][60][61][62]. The regulation of fungal BGCs occurs at the transcriptional and the epigenetic levels [23].…”

Section: Biotechnological Applications Of Secondary Metabolites Produ...mentioning

confidence: 99%

Potentials of Endophytic Fungi in the Biosynthesis of Versatile Secondary Metabolites and Enzymes

Slama¹,

Bouket

Alenezi

et al. 2021

Forests

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World population growth and modernization have engendered multiple environmental problems: the propagation of humans and crop diseases and the development of multi-drug-resistant fungi, bacteria and viruses. Thus, a considerable shift towards eco-friendly products has been seen in medicine, pharmacy, agriculture and several other vital sectors. Nowadays, studies on endophytic fungi and their biotechnological potentials are in high demand due to their substantial, cost-effective and eco-friendly contributions in the discovery of an array of secondary metabolites. For this review, we provide a brief overview of plant–endophytic fungi interactions and we also state the history of the discovery of the untapped potentialities of fungal secondary metabolites. Then, we highlight the huge importance of the discovered metabolites and their versatile applications in several vital fields including medicine, pharmacy, agriculture, industry and bioremediation. We then focus on the challenges and on the possible methods and techniques that can be used to help in the discovery of novel secondary metabolites. The latter range from endophytic selection and culture media optimization to more in-depth strategies such as omics, ribosome engineering and epigenetic remodeling.

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“…Endophytic microorganisms can produce bioactive secondary metabolites with a high degree of biological activities and structural diversity to be explored in human health (Gupta and Shukla, 2020;Adeleke and Babalola, 2021). Thus, bacteria and fungi isolated from different parts of plants can be easily culturable in laboratory under optimum culture conditions to manufacture NPs with desired characteristics and activities (Zielonka and Klimek-Ochab, 2017;Messaoudi and Bendahou, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Pieces of these plant parts are placed under specific conditions for optimal growth of microorganisms (culture medium, supplements, temperature, time, CO 2 rate, agitation, etc.) (Adeleke and Babalola, 2021). After growth, isolation of a target microorganism can occur, or use all microorganisms present.…”

Section: Introductionmentioning

confidence: 99%

Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare Applications

Bogas

Rodrigues

Gonçalves

et al. 2022

Front. Nanotechnol.

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Nanoparticles (NPs) have gained great attention in recent years due to their extensive and innovative applications in the field of medicine. However, conventional physicochemical approaches for the synthesis of NPs may be limited and costly, and the reaction by-products are potentially toxic for human health and the environment. Bio-mediated synthesis of NPs exploiting microorganisms as nanofactories has emerged as an alternative to traditional methods, as it provides economic and environmental benefits. Tropical ecosystems harbor a high diversity of endophytes, which have a diverse array of metabolic pathways that confer habitat adaptation and survival and that can be used to produce novel bioactive compounds with a variety of biological properties. Endophytic bacteria and fungi cultivated under optimum conditions have potential for use in biogenic synthesis of NPs with different characteristics and desired activities for medical applications, such as antimicrobial, antitumoral, antioxidant and anti-inflammatory properties. The bio-mediated synthesis of metal-based NPs can be favored because endophytic microorganisms may tolerate and/or adsorb metals and produce enzymes used as reducing agents. To our knowledge, this is the first review that brings together exclusively current research highlighting on the potential of endophytic bacteria and fungi isolated from native plants or adapted to tropical ecosystems and tropical macroalgae as nanofactories for the synthesis of NPs of silver, gold, copper, iron, zinc and other most studied metals, in addition to showing their potential use in human health.

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Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review

Cited by 92 publications

References 96 publications

Secondary Metabolite Production and Terpenoid Biosynthesis in Endophytic Fungi Cladosporium cladosporioides Isolated from Wild Cymbopogon martinii (Roxb.) Wats

Secondary Metabolite Production and Terpenoid Biosynthesis in Endophytic Fungi Cladosporium cladosporioides Isolated from Wild Cymbopogon martinii (Roxb.) Wats

Potentials of Endophytic Fungi in the Biosynthesis of Versatile Secondary Metabolites and Enzymes

Endophytic Microorganisms From the Tropics as Biofactories for the Synthesis of Metal-Based Nanoparticles: Healthcare Applications

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