Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review

Kifle, Zemene Demelash; Abdelwuhab, Mohammedbrhan; Melak, Abreham Degu; Genet, G/Mariam; Meseret, Tesfaye; Adugna, Meaza

doi:10.1016/j.metop.2022.100174

Cited by 16 publications

(17 citation statements)

References 86 publications

(112 reference statements)

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“…Male white mice that had been induced by alloxan were divided into five groups and given intake of aquadest (control), glibenclamine 13 mg/Kg BW (positive control), Gotu kola extract 200 mg/Kg BW (P1), 400 mg/Kg BW (P2) and 600 mg/Kg BW (P3). Mice were measured for blood sugar content on days 7:7-14 and 21:7-21 [15].…”

Section: Treatment Of Experimental Animalsmentioning

confidence: 99%

Antioxidant potential of gotu kola leaf extract (Centella asiatica (L.) Urban) as an alternative to antihyperglycemic herbal drinks

Damayanti¹,

Antari

Megayanti

2022

J. Pijar.MIPA

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This study aims to determine the antihyperglycemic potential of Gotu kola leaf extract (Centella asiatica (L.) Urban as an alternative herbal drink in diabetic male white mice. This study was divided into four stages: extracting Gotu kola leaves using 96% ethanol as solvent, phytochemical screening, and testing antihyperglycemic activity. Male white mice were made diabetic by alloxan-induced. Mice were divided into five groups consisting of negative control (Aquadest), positive control (Glibenclamide 13 mg/Kg BW), dose 1 (200 mg Gotu kola extract/kg BW), dose 2 (400 mg Gotu kola extract/kg BW), dose 2 (400 mg Gotu kola extract/kg BW), 3 (600 mg Gotu kola extract/kg BW). The results of phytochemical screening showed that the Gotu kola leaf extract was positive for flavonoids and tannins. The analysis results on the Gotu kola leaf extract showed an IC50 value of 80.58 ppm, including strong antioxidant activity. The results of the antihyperglycemic activity test showed that diabetic male white mice were found to have decreased blood sugar levels on days 14 and 21 by respectively 24.3% and 41.6%; 25.4% and 42.3%; 37.8% and 55.3% after administration of Gotu kola leaf extract at P1, P2, and P3.

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Section: Treatment Of Experimental Animalsmentioning

confidence: 99%

Antioxidant potential of gotu kola leaf extract (Centella asiatica (L.) Urban) as an alternative to antihyperglycemic herbal drinks

Damayanti¹,

Antari

Megayanti

2022

J. Pijar.MIPA

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“…The antihyperglycemic potential of the test extract could be attributed to suppression of glucose absorption, enhancement of peripheral glucose consumption, reduction in glycogenolysis, and gluconeogenesis [ 46 ]. Blocking glucose absorption by inhibiting intestinal α -glucosidase and pancreatic α -amylase activity has been shown in studies to reduce postprandial hyperglycemia [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice

Andargie

Sisay

Molla

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Conventional antidiabetic drugs are linked with a number of contraindications and untoward effects. The root decoction of Solanum incanum L. has traditionally been used to treat diabetes. However, its safety and efficacy have not been scientifically authenticated yet. Hence, the study was conducted in mice to corroborate its antidiabetic potential and safety profile. Methods. Using normoglycemic, oral glucose-loaded, and streptozotocin-induced diabetic mice models, the hypoglycemic and antihyperglycemic activities of 80% methanolic root extract were investigated. On streptozotocin-induced diabetic mice, the effect of the test extract on diabetic lipid profile and body weight was also investigated. Further, the in vitro α-amylase inhibition activity was assessed. Results. The test extract was safe at a limit test dose of 2 g/kg. Dose-dependent α-amylase inhibition activity was seen with peak percentage inhibition of 75.95% at 700 μg/mL. In normoglycemic mice, the plant extract showed statistically significant hypoglycemic activity at 200 and 400 mg/kg ( P < 0.001 ) at 6 h and 4 and 6 h of treatment, respectively; in oral glucose-loaded mice, at both the test doses, the glucose level was also significantly dropped at 120 ( P < 0.01 ) and 60 and 120 min ( P < 0.001 ), respectively; whereas, in the third model, the test extract showed significant antihyperglycemic activity at 100 mg/kg ( P < 0.05 ) on the 14th day and at 200 ( P < 0.01 ) and 400 mg/kg ( P < 0.001 ) on the 7th and 14th day of treatment. Similarly, following repeated administration of the test extract at 200 and 400 mg/kg, the body weight was significantly improved on the 14th day ( P < 0.05 ) and on the 7th and 14th day ( P < 0.01 ), respectively, while diabetic dyslipidemia after 14 days ( P < 0.05 ). Conclusion. The study revealed that the test extract showed promising antihyperglycemic and antihyperlipidemic activity. Thus, the findings back up its use in Ethiopian remedies for diabetes.

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“…More studies are required regarding the pharmacokinetics/pharmacodynamics of different phytoconstituents in laboratory animals and in clinical use to establish the benefits and mode(s) of action of these compounds in the treatment and management of diabetes. Extensive investigations into the pharmacology, toxicology, metabolism, and tissue distribution of medicinal plants and their phytomolecules are necessary for the development of new potent antidiabetic drugs [376].…”

Section: The Future Of Plant-based Antidiabetic Medicinesmentioning

confidence: 99%

Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus

et al. 2022

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Diabetes mellitus is a chronic complication that affects people of all ages. The increased prevalence of diabetes worldwide has led to the development of several synthetic drugs to tackle this health problem. Such drugs, although effective as antihyperglycemic agents, are accompanied by various side effects, costly, and inaccessible to the majority of people living in underdeveloped countries. Medicinal plants have been used traditionally throughout the ages to treat various ailments due to their availability and safe nature. Medicinal plants are a rich source of phytochemicals that possess several health benefits. As diabetes continues to become prevalent, health care practitioners are considering plant-based medicines as a potential source of antidiabetic drugs due to their high potency and fewer side effects. To better understand the mechanism of action of medicinal plants, their active phytoconstituents are being isolated and investigated thoroughly. In this review article, we have focused on pharmacologically active phytomolecules isolated from medicinal plants presenting antidiabetic activity and the role they play in the treatment and management of diabetes. These natural compounds may represent as good candidates for a novel therapeutic approach and/or effective and alternative therapies for diabetes.

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Pharmacological evaluation of medicinal plants with antidiabetic activities in Ethiopia: A review

Cited by 16 publications

References 86 publications

Antioxidant potential of gotu kola leaf extract (Centella asiatica (L.) Urban) as an alternative to antihyperglycemic herbal drinks

Antioxidant potential of gotu kola leaf extract (Centella asiatica (L.) Urban) as an alternative to antihyperglycemic herbal drinks

Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice

Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus

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